2016
mTOR has distinct functions in generating versus sustaining humoral immunity
Jones DD, Gaudette BT, Wilmore JR, Chernova I, Bortnick A, Weiss BM, Allman D. mTOR has distinct functions in generating versus sustaining humoral immunity. Journal Of Clinical Investigation 2016, 126: 4250-4261. PMID: 27760048, PMCID: PMC5096901, DOI: 10.1172/jci86504.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntibody FormationCell DifferentiationEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsImmunity, HumoralMechanistic Target of Rapamycin Complex 1MiceMice, TransgenicMultiprotein ComplexesPlasma CellsRegulatory-Associated Protein of mTORSignal TransductionTOR Serine-Threonine KinasesConceptsPlasma cellsBone marrow plasma cellsAntibody-associated diseaseSystemic lupus erythematosusMarrow plasma cellsAntibody-secreting plasma cellsPlasma cell differentiationLineage-specific deletionRole of mTORLupus erythematosusAcute treatmentExogenous antigensHumoral immunityAntibody responseSerum antibodiesMurine modelAntibody synthesisGerminal centersBone marrowCell differentiationMTOR inhibitionRobust protein synthesisMTOR activityRapamycin treatmentMTOR complex 1
2014
Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors
Chernova I, Jones DD, Wilmore JR, Bortnick A, Yucel M, Hershberg U, Allman D. Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors. The Journal Of Immunology 2014, 193: 4971-4979. PMID: 25326027, PMCID: PMC4234148, DOI: 10.4049/jimmunol.1401264.Peer-Reviewed Original ResearchConceptsBM plasma cellsPlasma cellsLong-term Ab responsesLong-term humoral responseBone marrow plasma cellsT cell-dependent AgSerum Ab titersIgG-secreting cellsRole of subpopulationsMarrow plasma cellsActivated B cellsPC poolAb titersHumoral responseAntibody responseIgG AbsAb responsesL chain usageIgM AbsB cellsHapten-protein conjugatesPC subsetsChain usageIgM