Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway
Kim HR, Hwang KA, Kang I. Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway. The Journal Of Immunology 2007, 179: 6734-6740. PMID: 17982063, DOI: 10.4049/jimmunol.179.10.6734.Peer-Reviewed Original ResearchMeSH KeywordsCD8-Positive T-LymphocytesCell ProliferationCell SurvivalEnzyme ActivationGene Expression RegulationHumansImmunologic MemoryInfectionsInterleukin-15Interleukin-2 Receptor beta SubunitInterleukin-7NeoplasmsPerforinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReceptors, Antigen, T-CellReceptors, CCR7Receptors, Interleukin-17Signal TransductionConceptsIL-15T cellsPI3K/Akt pathwayAkt pathwayIL-7Memory T cell survivalProliferation of ILIL-15 signalingHuman peripheral bloodT cell survivalEffector cytokinesMemory CD8Peripheral bloodEffector functionsIL-7REnhanced gene expressionProliferative functionIndependent mechanismsILTCR triggeringCell survivalSuch cellsSurvivalTranscriptional factorsDual role