2010
Human IL-7Rαlow memory CD8+ T cells have defect in the calcium signaling pathway in response to TCR triggering, leading to impaired IL-2 production and proliferation. (132.34)
Lee H, Yu M, Lee D, Kang J, Hwang Y, Lee W, Kang I, Kim H. Human IL-7Rαlow memory CD8+ T cells have defect in the calcium signaling pathway in response to TCR triggering, leading to impaired IL-2 production and proliferation. (132.34). The Journal Of Immunology 2010, 184: 132.34-132.34. DOI: 10.4049/jimmunol.184.supp.132.34.Peer-Reviewed Original ResearchIL-2 productionMemory CD8T cellsCytokine productionIL-7Effector cytokine productionT cell subsetsAnergic T cellsPMA/ionomycin treatmentAnti-CD3 AbTCR triggeringEffector cytokinesAnergic phenotypeCell subsetsHuman CD8IL-2CD8Calcium fluxTCR stimulationIonomycin treatmentCell survival responseMAPK pathwayCellular characteristicsProliferationCells
2007
Down-Regulation of IL-7Rα Expression in Human T Cells via DNA Methylation
Kim HR, Hwang KA, Kim KC, Kang I. Down-Regulation of IL-7Rα Expression in Human T Cells via DNA Methylation. The Journal Of Immunology 2007, 178: 5473-5479. PMID: 17442928, DOI: 10.4049/jimmunol.178.9.5473.Peer-Reviewed Original ResearchConceptsJurkat T cellsDNA methylationGene expressionGene promoterIL-7Ralpha expressionT cellsPromoter activityImportant gene regulatory mechanismGene regulatory mechanismsGene promoter constructsHuman CD8Gene promoter activityIL-7Cell survival responseT cell developmentT cell subsetsIL-7Rα expressionRegulatory mechanismsPromoter constructsCell developmentMethylationLuciferase reporterHuman T cellsSurvival responseDown regulationThe role for DNA methylation in differentially regulating IL-7 receptor alpha expression by human T cells (94.22)
Kang I, Hwang K, Kim K, Kim H. The role for DNA methylation in differentially regulating IL-7 receptor alpha expression by human T cells (94.22). The Journal Of Immunology 2007, 178: s174-s174. DOI: 10.4049/jimmunol.178.supp.94.22.Peer-Reviewed Original ResearchJurkat T cellsDNA methylationGene promoterT cellsGene expressionImportant gene regulatory mechanismHuman CD8IL-7Gene regulatory mechanismsGene promoter constructsCell survival responseReceptor alpha expressionT cell subsetsT cell developmentHuman T cellsRegulatory mechanismsPromoter activityPromoter constructsCell developmentCell subsetsIL-7RaMethylationCD8Luciferase reporterAlpha expression