2021
Respiratory Syncytial Virus–Associated Mortality Among Young Infants in Karachi, Pakistan: A Prospective Postmortem Surveillance Study
Kazi AM, Aguolu OG, Mughis W, Ahsan N, Jamal S, Khan A, Qureshi HM, Yildirim I, Malik FA, Omer SB. Respiratory Syncytial Virus–Associated Mortality Among Young Infants in Karachi, Pakistan: A Prospective Postmortem Surveillance Study. Clinical Infectious Diseases 2021, 73: s203-s209. PMID: 34472574, PMCID: PMC8411247, DOI: 10.1093/cid/ciab488.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusRespiratory symptomsInfant deathRSV seasonalityRole of RSVYoung infantsPresence of RSVMultivariable logistic regression analysisMaternal immunization strategiesSignificant mortality burdenVaccine-hesitant populationYoung infant deathsMultivariable logistic regressionCold-like symptomsSignificant predictorsLogistic regression analysisPostneonatal ageRSV mortalityRSV seasonMaternal immunizationInfant morbidityNasopharyngeal specimensNasopharyngeal swabsSyncytial virusRespiratory illness
2020
Differences in maternal group B Streptococcus screening rates in Latin American countries
HogenEsch E, De Mucio B, Haddad LB, Vilajeliu A, Ropero AM, Yildirim I, Omer SB. Differences in maternal group B Streptococcus screening rates in Latin American countries. Vaccine 2020, 39: b3-b11. PMID: 33308886, DOI: 10.1016/j.vaccine.2020.10.082.Peer-Reviewed Original ResearchConceptsMaternal GBS screeningMaternal GBS colonizationGBS screeningGBS colonizationScreening ratesPregnant womenGroup B Streptococcus ScreeningMaternal group B StreptococcusLogistic regressionGBS colonization prevalenceIntrapartum antibiotic treatmentMaternal GBS vaccineNeonatal GBS diseaseAdverse neonatal outcomesRetrospective observational studyMaternal age groupsGroup B streptococciDemographic variablesLower ratesGBS prevalenceFinal regression modelGBS diseaseNeonatal outcomesNeonatal sepsisGBS vaccine
2019
Assessment and Validation of Syndromic Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis.
Lalani K, Yildirim I, Phadke VK, Bednarczyk RA, Omer SB. Assessment and Validation of Syndromic Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis. The Pediatric Infectious Disease Journal 2019, 38: 1177-1182. PMID: 31568250, DOI: 10.1097/inf.0000000000002468.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusSyndromic case definitionsCase definitionYoung infantsWorld Health OrganizationRSV infectionLatent class analysisPredictive valueLaboratory-confirmed RSV infectionRespiratory syncytial virus infectionSyncytial virus infectionAcute respiratory infectionsHigh positive predictive valueRoutine clinical careStandardized case definitionsHigh-resource settingsAppropriate case definitionsHigh-income settingsNegative predictive valueMonths of agePositive predictive valueRespiratory infectionsVaccine evaluationClinical featuresPediatric morbidityIncidence of invasive Haemophilus influenzae infections in children with sickle cell disease
Yee ME, Bakshi N, Graciaa SH, Lane PA, Jerris RC, Wang YF, Yildirim I. Incidence of invasive Haemophilus influenzae infections in children with sickle cell disease. Pediatric Blood & Cancer 2019, 66: e27642. PMID: 30724001, PMCID: PMC6472970, DOI: 10.1002/pbc.27642.Peer-Reviewed Original ResearchConceptsSickle cell diseaseComprehensive clinical databaseInfluenzae infectionAntibiotic prophylaxisInfluenzae diseaseInvasive infectionsCell diseaseInvasive Haemophilus influenzae infectionsPediatric tertiary care centerHaemophilus influenzae type bLarge pediatric tertiary care centerUniversal antibiotic prophylaxisSterile body fluid culturesTertiary care centerHaemophilus influenzae infectionsBody fluid culturesInfluenzae type bYears of ageDistribution of serotypesNonvaccine serotypesClinical featuresOverall incidenceCare centerFluid cultureIncidence rate
2018
The relative invasive disease potential of Streptococcus pneumoniae among children after PCV introduction: A systematic review and meta-analysis
Balsells E, Dagan R, Yildirim I, Gounder PP, Steens A, Muñoz-Almagro C, Mameli C, Kandasamy R, Lavi N, Daprai L, van der Ende A, Trzciński K, Nzenze SA, Meiring S, Foster D, Bulkow LR, Rudolph K, Valero-Rello A, Ducker S, Vestrheim DF, von Gottberg A, Pelton SI, Zuccotti G, Pollard AJ, Sanders EAM, Campbell H, Madhi SA, Nair H, Kyaw MH. The relative invasive disease potential of Streptococcus pneumoniae among children after PCV introduction: A systematic review and meta-analysis. Journal Of Infection 2018, 77: 368-378. PMID: 29964140, DOI: 10.1016/j.jinf.2018.06.004.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseInvasive disease potentialPneumococcal conjugate vaccineNon-vaccine typesPCV introductionPneumococcal diseaseClinical syndromePneumococcal serotypesSurveillance of IPDDisease potentialSystematic reviewCurrent pneumococcal conjugate vaccinesYears of ageRandom-effects modelConjugate vaccineRoutine immunisationDisease presentationFuture vaccinesStreptococcus pneumoniaeSerotype 1SerotypesSyndromeCarriageChildrenVaccine
2017
Surveillance of pneumococcal colonization and invasive pneumococcal disease reveals shift in prevalent carriage serotypes in Massachusetts’ children to relatively low invasiveness
Yildirim I, Little BA, Finkelstein J, Lee G, Hanage WP, Shea K, Pelton SI, T, Health H. Surveillance of pneumococcal colonization and invasive pneumococcal disease reveals shift in prevalent carriage serotypes in Massachusetts’ children to relatively low invasiveness. Vaccine 2017, 35: 4002-4009. PMID: 28645717, DOI: 10.1016/j.vaccine.2017.05.077.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePneumococcal conjugate vaccineInvasive disease potentialPneumococcal diseaseLow invasive capacityInvasive capacityPCV13 eraCommon serotypesIncidence of IPDNasopharyngeal colonization ratePost-vaccine eraDisease potentialCarriage serotypesPCV eraConjugate vaccineNasopharyngeal carriageCarriage prevalencePneumococcal colonizationEnhanced surveillanceDynamic epidemiologyAge groupsSerotype 3Serotype XOlder childrenLow invasiveness
2015
Pneumococcal Disease in the Era of Pneumococcal Conjugate Vaccine
Yildirim I, Shea KM, Pelton SI. Pneumococcal Disease in the Era of Pneumococcal Conjugate Vaccine. Infectious Disease Clinics Of North America 2015, 29: 679-697. PMID: 26610421, PMCID: PMC4662776, DOI: 10.1016/j.idc.2015.07.009.Peer-Reviewed Original ResearchConceptsPneumococcal conjugate vaccinePneumococcal diseaseConjugate vaccineOtitis mediaUniversal immunizationAcute otitis mediaInvasive pneumococcal diseaseCase fatality rateVulnerable pediatric patientsSpectrum of serotypesCause pneumoniaPediatric patientsComorbid conditionsHealthy childrenFatality rateDiseaseHost susceptibilityImmunizationVaccineHigh rateChildrenEmpyemaMastoiditisPneumoniaPatients
2010
Serotype specific invasive capacity and persistent reduction in invasive pneumococcal disease
Yildirim I, Hanage WP, Lipsitch M, Shea KM, Stevenson A, Finkelstein J, Huang SS, Lee GM, Kleinman K, Pelton SI. Serotype specific invasive capacity and persistent reduction in invasive pneumococcal disease. Vaccine 2010, 29: 283-288. PMID: 21029807, PMCID: PMC3139683, DOI: 10.1016/j.vaccine.2010.10.032.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseInvasive capacityPneumococcal diseaseIncidence of IPDNew pneumococcal conjugate vaccinesPneumococcal conjugate vaccineSterile body sitesStreptococcus pneumoniae serotypesCarriage serotypesNasopharyngeal acquisitionNP carriagePCV eraReplacement serotypesIPD incidenceRespiratory seasonsConjugate vaccineMassachusetts childrenCarriage prevalenceCommon serotypesPneumoniae serotypesOngoing surveillanceEnhanced surveillanceBody sitesPersistent reductionSerotype X
2009
Multicenter Prospective Study on the Burden of Rotavirus Gastroenteritis in Turkey, 2005–2006: A Hospital-Based Study
Ceyhan M, Alhan E, Salman N, Kurugol Z, Yildirim I, Celik U, Keser M, Koturoglu G, Tezer H, Bulbul EK, Karabocuoglu M, Halicioglu O, Anis S, Pawinski R. Multicenter Prospective Study on the Burden of Rotavirus Gastroenteritis in Turkey, 2005–2006: A Hospital-Based Study. The Journal Of Infectious Diseases 2009, 200: s234-s238. PMID: 19817603, DOI: 10.1086/605056.Peer-Reviewed Original ResearchConceptsRotavirus gastroenteritisWorld Health Organization's generic protocolRotavirus-positive childrenPrevalence of rotavirusMulticenter prospective studyRotavirus vaccineProspective surveillanceProspective studyDisease burdenMortality rateGastroenteritisPrevalent strainsRotavirusIndividual centersChildrenBurdenMain causeHospitalizationHospitalInfantsVaccineYearsPrevalence
2008
A Chryseobacterium meningosepticum outbreak observed in 3 clusters involving both neonatal and non-neonatal pediatric patients
Ceyhan M, Yıldırım I, Tekelı A, Yurdakok M, Us E, Altun B, Kutluk T, Cengiz AB, Gurbuz V, Barın C, Bagdat A, Cetınkaya D, Gur D, Tuncel O. A Chryseobacterium meningosepticum outbreak observed in 3 clusters involving both neonatal and non-neonatal pediatric patients. American Journal Of Infection Control 2008, 36: 453-457. PMID: 18675153, DOI: 10.1016/j.ajic.2007.09.008.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsChryseobacteriumCluster AnalysisCross InfectionDisease OutbreaksDNA FingerprintingDNA, BacterialEnvironmental MicrobiologyFemaleFlavobacteriaceae InfectionsGenotypeHandHealth PersonnelHospital UnitsHumansInfantInfant, NewbornMaleMicrobial Sensitivity TestsRandom Amplified Polymorphic DNA TechniqueTurkeyConceptsNon-neonatal pediatric patientsHealth care workers' handsNeonatal intensive care unitTertiary health centerEnterobacterial repetitive intergenic consensus sequence polymerase chain reactionIntensive care unitInfection control measuresMeningosepticum infectionOlder patientsPediatric patientsPremature infantsCare unitPediatric wardPolymerase chain reactionHand culturesHealth centersIndex patientsNosocomial infectionsAmbu bagPatientsEtiologic agentAntimicrobial treatmentPowdered infant formulaOutbreak investigationInfant formulaComparing body temperature measurements by mothers and physicians using mercury-in-glass, digital mercury and infrared tympanic membrane thermometers in healthy newborn babies.
Cultu O, Yildirim I, Ceyhan M, Korkmaz A, Yurdakök M, Karaağaoğlu E, Seçmeer G. Comparing body temperature measurements by mothers and physicians using mercury-in-glass, digital mercury and infrared tympanic membrane thermometers in healthy newborn babies. The Turkish Journal Of Pediatrics 2008, 50: 354-8. PMID: 19014049.Peer-Reviewed Original ResearchConceptsNewborn babiesTympanic membrane thermometerEducational levelHealthy newborn babiesHealth care workersBody temperatureBody temperature changesHealthy newbornsProspective studyCare workersMedical carePediatriciansPrevious childIntraclass coefficientAbsolute differencePhysiciansTympanic thermometer measurementsMothersTympanic thermometerBody temperature measurementPresence of childrenBabiesDegrees CChildrenThermometer readings
2007
Age-specific seroprevalence of serogroup C meningococcal serum bactericidal antibody activity and serogroup A, C, W135 and Y-specific IgG concentrations in the Turkish population during 2005
Ceyhan M, Yildirim I, Balmer P, Riley C, Laher G, Andrews N, Borrow R, Kurt N, Turgut M, Aydogan A, Ecevit C, Uysal G, Schultze V. Age-specific seroprevalence of serogroup C meningococcal serum bactericidal antibody activity and serogroup A, C, W135 and Y-specific IgG concentrations in the Turkish population during 2005. Vaccine 2007, 25: 7233-7237. PMID: 17707957, DOI: 10.1016/j.vaccine.2007.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAntibodies, BacterialChildChild, PreschoolFemaleHumansImmunoglobulin GInfantInfant, NewbornMaleMeningococcal InfectionsMicrobial ViabilityMiddle AgedNeisseria meningitidis, Serogroup ANeisseria meningitidis, Serogroup CNeisseria meningitidis, Serogroup W-135Neisseria meningitidis, Serogroup YSeroepidemiologic StudiesTurkeyConceptsSerum bactericidal antibodySerogroups ASerogroup CIgG concentrationsMeningococcal serogroup C diseaseSerum bactericidal antibody activityTurkish populationMeningococcal serogroup CMeningococcal vaccination programsSerogroup C diseaseAge-specific seroprevalenceSpecific IgG concentrationsRates of susceptibilityBactericidal antibody activityBaseline seroprevalenceSBA titersAntibody levelsProtective antibodiesIgG antibodiesVaccination programBactericidal antibodiesHealth centersC diseaseStudy populationC meningococci