2023
Age-dependent impairment in antibody responses elicited by a homologous CoronaVac booster dose
Filardi B, Monteiro V, Schwartzmann P, do Prado Martins V, Zucca L, Baiocchi G, Malik A, Silva J, Hahn A, Chen N, Pham K, Pérez-Then E, Miric M, Brache V, Cochon L, Larocca R, Della Rosa Mendez R, Silveira D, Pinto A, Croda J, Yildirim I, Omer S, Ko A, Vermund S, Grubaugh N, Iwasaki A, Lucas C, Initiative Y, Vogels C, Breban M, Koch T, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry M, Schulz W. Age-dependent impairment in antibody responses elicited by a homologous CoronaVac booster dose. Science Translational Medicine 2023, 15: eade6023. PMID: 36791210, DOI: 10.1126/scitranslmed.ade6023.Peer-Reviewed Original ResearchConceptsBooster doseAntibody responseNeutralization titersVirus-specific IgG titersOlder adultsAntiviral humoral immunityPlasma antibody responsesHigh-risk populationSARS-CoV-2 spikeYears of ageAge-dependent impairmentHeterologous regimensBooster dosesBooster vaccineCoronaVac vaccineIgG titersProtective immunityHumoral immunityHumoral responseCoronaVacOmicron waveBooster strategyAge groupsEarly controlVaccine
2019
2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF)
Anderson E, Hussaini L, Bristow L, Tippett A, Gibson T, Hart M, Salazar L, Gaffney M, Benyeogor I, Cheng A, Drobeniuc A, Traenkner J, Fayad D, Washington W, Emerson L, Schwartz N, Greaves K, Todd S, Stanley C, Bechnak A, Chaaya R, Al-Husien Z, Deović R, Winston J, Ahmed D, Li W, Le K, Singh A, Spencer J, Muchinsky A, Zaks K, Nesheim W, Stephens K, Swerdlow D, Hubler R, Agosti Y, Munye M, Jadhao S, Ha B, McCracken C, Kraft C, Rostad C, Kao C, Lopman B, Yildirim I, Anderson L, Rouphael N, Rouphael N. 2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF). Open Forum Infectious Diseases 2019, 6: s793-s794. PMCID: PMC6810302, DOI: 10.1093/ofid/ofz360.1992.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseCongestive heart failureAcute respiratory infectionsRespiratory viral panelYears of ageHealthy controlsRespiratory syncytial virus infectionOlder adultsRSV antibody titersSyncytial virus infectionObstructive pulmonary diseaseRespiratory syncytial virusFour-fold riseConvalescent serologyClinical characteristicsHeart failurePulmonary diseaseRespiratory infectionsAsymptomatic adultsEligible adultsProspective surveillanceSyncytial virusViral panelAntibody titersOropharyngeal swabs