Featured Publications
Prevalence of Chronic Diseases, Depression, and Stress Among US Childcare Professionals During the COVID-19 Pandemic
Elharake JA, Shafiq M, Cobanoglu A, Malik AA, Klotz M, Humphries JE, Murray T, Patel KM, Wilkinson D, Yildirim I, Diaz R, Rojas R, Cohen A, Lee A, Omer SB, Gilliam WS. Prevalence of Chronic Diseases, Depression, and Stress Among US Childcare Professionals During the COVID-19 Pandemic. Preventing Chronic Disease 2022, 19: e61. PMID: 36137183, PMCID: PMC9541678, DOI: 10.5888/pcd19.220132.Peer-Reviewed Original ResearchConceptsPhysical health conditionsMental healthHealth conditionsChronic diseasesDepression ratesCOVID-19 pandemicSex/gender disparityPublic health officialsChildcare professionalsSevere asthmaHeart diseaseUS adultsAsthma ratesSociodemographic characteristicsHealth officialsDepressionDiseaseNational representativenessLinear regression modelsPrevalenceHealthRegression modelsPandemicProfessionalsGender disparities
2022
The Impact of Testing Capacity and Compliance With Isolation on COVID-19: A Mathematical Modeling Study
Yu Z, Keskinocak P, Steimle L, Yildirim I. The Impact of Testing Capacity and Compliance With Isolation on COVID-19: A Mathematical Modeling Study. AJPM Focus 2022, 1: 100006. PMID: 36942015, PMCID: PMC9119710, DOI: 10.1016/j.focus.2022.100006.Peer-Reviewed Original ResearchTesting capacityCOVID-19Infection attack rateInfectious respiratory diseaseFuture pandemicsAdditional testing capacityEarly startLow testing capacityRespiratory diseaseBenefits of testingDiagnostic testingAbsence of testingDiagnostic testsAttack rateDays of delayHigh compliancePublic healthInfection spreadDiseaseStart of testingSignificant benefitsPandemicComplianceMathematical modeling studiesPotential benefits
2020
Brincidofovir for the treatment of human adenovirus infection in pediatric solid organ transplant recipients: A case series
Londeree J, Winterberg PD, Garro R, George RP, Shin S, Liverman R, Serluco A, Romero R, Yildirim I. Brincidofovir for the treatment of human adenovirus infection in pediatric solid organ transplant recipients: A case series. Pediatric Transplantation 2020, 24: e13769. PMID: 32558134, DOI: 10.1111/petr.13769.Peer-Reviewed Original ResearchConceptsPediatric SOT recipientsSOT recipientsCase seriesSevere diseasePediatric solid organ transplant recipientsSolid organ transplant recipientsType of allograftMainstay of treatmentOrgan transplant recipientsSeverity of diseaseHuman adenovirus infectionHAdV diseaseHAdV viremiaPediatric recipientsTransplant recipientsHAdV infectionDisease courseAntiviral therapySignificant morbidityDisease presentationUS FDAAdenovirus infectionBrincidofovirDiseaseRecipients
2018
Infants at Risk for Invasive Pneumococcal Disease in the 13-Valent Pneumococcal Conjugate Vaccine Era
Yildirim I, Pelton SI. Infants at Risk for Invasive Pneumococcal Disease in the 13-Valent Pneumococcal Conjugate Vaccine Era. Clinical Infectious Diseases 2018, 69: 91-92. PMID: 30281070, DOI: 10.1093/cid/ciy848.Peer-Reviewed Original Research
2015
Pneumococcal Disease in the Era of Pneumococcal Conjugate Vaccine
Yildirim I, Shea KM, Pelton SI. Pneumococcal Disease in the Era of Pneumococcal Conjugate Vaccine. Infectious Disease Clinics Of North America 2015, 29: 679-697. PMID: 26610421, PMCID: PMC4662776, DOI: 10.1016/j.idc.2015.07.009.Peer-Reviewed Original ResearchConceptsPneumococcal conjugate vaccinePneumococcal diseaseConjugate vaccineOtitis mediaUniversal immunizationAcute otitis mediaInvasive pneumococcal diseaseCase fatality rateVulnerable pediatric patientsSpectrum of serotypesCause pneumoniaPediatric patientsComorbid conditionsHealthy childrenFatality rateDiseaseHost susceptibilityImmunizationVaccineHigh rateChildrenEmpyemaMastoiditisPneumoniaPatients
2014
1095Invasive Pneumococcal Disease in Children with Underlying Conditions Has Higher Case Fatality and Unique Serotype Distribution
Yildirim I, Shea K, Little B, Silverio A, Hsu K, Pelton S. 1095Invasive Pneumococcal Disease in Children with Underlying Conditions Has Higher Case Fatality and Unique Serotype Distribution. Open Forum Infectious Diseases 2014, 1: s323-s323. PMCID: PMC5781699, DOI: 10.1093/ofid/ofu052.803.Peer-Reviewed Original Research
2010
Risks and outcome of fungal infection in neutropenic children with hematologic diseases.
Aytaç S, Yildirim I, Ceyhan M, Cetin M, Tuncer M, Kara A, Cengiz AB, Seçmeer G, Yetgin S. Risks and outcome of fungal infection in neutropenic children with hematologic diseases. The Turkish Journal Of Pediatrics 2010, 52: 121-5. PMID: 20560245.Peer-Reviewed Original ResearchConceptsFebrile neutropenic episodesAcute myeloid leukemiaNeutropenic episodesAcute lymphoblastic leukemiaAplastic anemiaAntifungal treatmentFungal infectionsMortality rateAmphotericin BNeutropenic childrenRetrospective studyLymphoblastic leukemiaMyeloid leukemiaHematologic diseasesTreatment groupsPatientsWhole groupInfectionEpisodesLeukemiaMortalityAnemiaGroupDiseaseFluconazole
2008
A Prospective Study of Etiology of Childhood Acute Bacterial Meningitis, Turkey - Volume 14, Number 7—July 2008 - Emerging Infectious Diseases journal - CDC
Ceyhan M, Yildirim I, Balmer P, Borrow R, Dikici B, Turgut M, Kurt N, Aydogan A, Ecevit C, Anlar Y, Gulumser O, Tanir G, Salman N, Gurler N, Hatipoglu N, Hacimustafaoglu M, Celebi S, Coskun Y, Alhan E, Celik U, Camcioglu Y, Secmeer G, Gur D, Gray S. A Prospective Study of Etiology of Childhood Acute Bacterial Meningitis, Turkey - Volume 14, Number 7—July 2008 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2008, 14: 1089-1096. PMID: 18598630, PMCID: PMC2600347, DOI: 10.3201/eid1407.070938.Peer-Reviewed Original ResearchConceptsAcute bacterial meningitisBacterial meningitisSerogroup WCSF samplesChildhood acute bacterial meningitisHaemophilus influenzae type bInfectious Diseases journal - CDCEtiology of meningitisInfluenzae type bCerebrospinal fluid samplesPCR-positive samplesProspective studyBacterial etiologyMeningococcal diseaseVaccination policyCost of diseaseMeningitisS. pneumoniaeStreptococcus pneumoniaeClinical diagnosisEtiologyN. meningitidisNeisseria meningitidisDiseaseType B
2007
Isolated testicular and bone relapse in children with acute myeloblastic leukemia and chronic graft versus host disease after allogeneic BMT.
Yildirim I, Uçkan D, Cetin M, Tuncer M, Tezcan I. Isolated testicular and bone relapse in children with acute myeloblastic leukemia and chronic graft versus host disease after allogeneic BMT. The Turkish Journal Of Pediatrics 2007, 49: 206-9. PMID: 17907524.Peer-Reviewed Original ResearchConceptsBone marrow transplantationAcute myeloblastic leukemiaAllogeneic bone marrow transplantationChronic GVHDHost diseaseMyeloblastic leukemiaIsolated extramedullary relapseImmune-privileged sitePost-transplant casesBone relapseChronic graftExtramedullary relapseTesticular relapseBronchiolitis obliteransLeukemic relapseGranulocytic sarcomaMarrow transplantationDecreased incidenceLeukemic cellsRelapseTwo yearsRare occasionsGraftLeukemiaDisease