2018
2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity
Lou B, Liu Q, Hou J, Kabir I, Liu P, Ding T, Dong J, Mo M, Ye D, Chen Y, Bui HH, Roth K, Cao Y, Jiang XC. 2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity. Journal Of Biological Chemistry 2018, 293: 18328-18336. PMID: 30305392, PMCID: PMC6254338, DOI: 10.1074/jbc.ra118.005904.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsCell Line, TumorEnzyme ActivationEnzyme ActivatorsHumansMiceMice, Inbred C57BLNeoplasmsOleic AcidsPhosphatidylcholinesSphingomyelinsTransferases (Other Substituted Phosphate Groups)ConceptsSMS activationAnticancer effectsCancer cell cycle arrestU118 cellsDose-dependent fashionSM activityPlasma phosphatidylcholinePredictive biomarkersTumor responseC57BL/6J miceCell cycle arrestTotal cellular phosphatidylcholinePotent anticancer drugLysophosphatidylcholine acyltransferase activitySphingomyelin levelsCancer cellsPhosphatidylcholine metabolismTissue homogenatesSphingomyelin accumulationCycle arrestSphingomyelin synthase activityMouse tissue homogenatesAnticancer propertiesCancer suppressionAcyltransferase activity
2015
All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity[S]
Ding T, Kabir I, Li Y, Lou C, Yazdanyar A, Xu J, Dong J, Zhou H, Park T, Boutjdir M, Li Z, Jiang XC. All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity[S]. Journal Of Lipid Research 2015, 56: 537-545. PMID: 25605874, PMCID: PMC4340302, DOI: 10.1194/jlr.m054627.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsMiceMice, KnockoutSphingomyelinsTransferases (Other Substituted Phosphate Groups)ConceptsCeramide phosphoethanolamineCPE levelsSynthase activityObvious phenotypic alterationsSynthase gene familySf9 insect cellsQuantitative MS analysisGene familyCeramide homeostasisInsect cellsCritical regulatorNBD-ceramideSMS2 activityPhenotypic alterationsSMS1SMS1 deficiencySphingolipid levelsSMS2Ceramide levelsCell functionKO miceCell studiesMS analysisFamily membersCells