2024
Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment
Gross G, Spiller T, Ben-Zion Z, Rubenstein A, Pietrzak R, Duek O, Hoff R, Harpaz-Rotem I. Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment. Psychological Trauma Theory Research Practice And Policy 2024 PMID: 38990694, DOI: 10.1037/tra0001734.Peer-Reviewed Original ResearchPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder clustersSymptom clustersIntrusive symptomsResidential treatmentTreatment of posttraumatic stress disorderPosttraumatic stress disorder symptomsResidential PTSD treatmentPTSD symptom clustersNovel treatment interventionsDifferential treatment responseReduce symptom severityDifferential patterns of changeAvoidance symptomsPTSD treatmentTreatment gainsStress disorderVeterans AffairsSymptom severityCluster CTreatment interventionsCluster BIndividual symptomsCohort of veteransFunctional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Stiltner B, Fischer I, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak R. Functional correlates of a novel 8-factor model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Psychiatric Research 2024, 171: 69-74. PMID: 38244335, DOI: 10.1016/j.jpsychires.2024.01.017.Peer-Reviewed Original ResearchConceptsModels of posttraumatic stress disorderPosttraumatic stress disorderNational Health and ResilienceU.S. military veteransArousal symptomsSuicidal ideationVeterans StudyCurrent depressionSymptom clustersMilitary veteransPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder symptomsPosttraumatic Stress Disorder ChecklistAnxious arousal symptomsDysphoric arousal symptomsIntrusive symptom clustersOdds of suicidal ideationFunctional correlatesMulti-faceted disorderExternalizing behavioral symptomsAssociated with lower oddsAssociated with higher oddsSymptom structureAvoidance symptomsDSM-5
2023
The Functional Significance of a Novel Conceptualization of Intrusion Symptoms of PTSD
Spiller T, Gross G, Duek O, Pietrzak R, Harpaz-Rotem I. The Functional Significance of a Novel Conceptualization of Intrusion Symptoms of PTSD. European Psychiatry 2023, 66: s476-s477. PMCID: PMC10434546, DOI: 10.1192/j.eurpsy.2023.1020.Peer-Reviewed Original ResearchPosttraumatic stress disorderIntrusion symptomsResidential treatment programEmotional functioningFactors of PTSDSymptoms of PTSDSymptom clustersDistinct underlying processesDisclosure of interestSelf-report formCore defining featuresStructural equation modellingPhysical functioningGood model fitStress disorderPTSD ChecklistIntrusion factorCorresponding subscalesPreliminary empirical evidenceInitial supportDSM-5Equation modellingTreatment programSuperior fitBiological underpinnings
2022
Distinguishing emotional numbing symptoms of posttraumatic stress disorder from major depressive disorder
Duek O, Seidemann R, Pietrzak R, Harpaz-Rotem I. Distinguishing emotional numbing symptoms of posttraumatic stress disorder from major depressive disorder. Journal Of Affective Disorders 2022, 324: 294-299. PMID: 36586605, DOI: 10.1016/j.jad.2022.12.105.Peer-Reviewed Original ResearchConceptsEmotional numbing symptomsPosttraumatic stress disorderNumbing symptomsEmotional numbingStress disorderSymptom clustersTrauma-exposed individualsGreater PTSD severityMajor depressive disorderContext of traumaUnique variancePTSD symptomsPTSD phenotypePTSD severityDifferent symptom clustersWorse treatment outcomesDepressive disorderCore aspectsNumbingDistinct contributionsMDD symptomsDSM-IIIFunctional impairmentDisordersTreatment outcomesRisk for PTSD symptom worsening during new PTSD treatment episode in a nationally representative sample of treatment-seeking U.S. veterans with subthreshold PTSD
Gross GM, Pietrzak RH, Hoff RA, Katz IR, Harpaz-Rotem I. Risk for PTSD symptom worsening during new PTSD treatment episode in a nationally representative sample of treatment-seeking U.S. veterans with subthreshold PTSD. Journal Of Psychiatric Research 2022, 151: 304-310. PMID: 35526446, DOI: 10.1016/j.jpsychires.2022.04.040.Peer-Reviewed Original ResearchConceptsSymptom worseningRisk factorsSubthreshold PTSDPTSD symptom clustersSymptom clustersPTSD symptomsHealth care utilizationPTSD specialty clinicPoor treatment outcomesUnited States veteransBinary logistic regressionAdjusted analysisCare utilizationTreatment episodesRepresentative sampleSpecialty clinicSignificant symptomsTreatment outcomesSignificant worseningStates veteransSubthreshold symptomsEligible veteransNew episodesOutcome assessmentDiagnostic threshold
2021
Cannabinoid Receptor 1 rs1049353 Variant, Childhood Abuse, and the Heterogeneity of PTSD Symptoms: Results From the National Health and Resilience in Veterans Study
Korem N, Duek O, Xu K, Harpaz-Rotem I, Pietrzak RH. Cannabinoid Receptor 1 rs1049353 Variant, Childhood Abuse, and the Heterogeneity of PTSD Symptoms: Results From the National Health and Resilience in Veterans Study. Chronic Stress 2021, 5: 24705470211011075. PMID: 33997583, PMCID: PMC8107935, DOI: 10.1177/24705470211011075.Peer-Reviewed Original ResearchPosttraumatic stress disorderOverall PTSD symptomsAnxious arousal symptomsPTSD symptomsNational HealthChildhood abuseVeterans StudySymptom clustersArousal symptomsAllele carrier statusArousal symptom clustersMultivariable analysisEndocannabinoid systemAllele carriersPTSD symptom clustersGene-environment studiesGreater severityG homozygotesU.S. veteransSymptomsStress disorderCarrier statusReceptor geneDisordersSignificant main effect
2018
Locus of control in US combat veterans: Unique associations with posttraumatic stress disorder 5-factor model symptom clusters
Smith NB, Sippel LM, Presseau C, Rozek D, Mota N, Gordon C, Horvath M, Harpaz-Rotem I. Locus of control in US combat veterans: Unique associations with posttraumatic stress disorder 5-factor model symptom clusters. Psychiatry Research 2018, 268: 152-156. PMID: 30029062, DOI: 10.1016/j.psychres.2018.07.015.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLocus of controlPTSD symptom clustersOverall PTSD symptomsAvoidance symptomsPTSD symptomsSymptom clustersStress disorderCombat veteransExternal locusCombat exposureCorrelates of PTSDSpecific PTSD symptom clustersTrauma-focused treatmentSelf-report measuresUS combat veteransIntervention effortsUnique associationUS military veteransExtreme scoresPotential correlatesMilitary veteransBivariate correlationsOnly avoidanceSignificant correlatesThe Unique Roles of Emotional Numbing and Arousal Symptoms in Relation to Social Connectedness Among Military Veterans in Residential Treatment for PTSD
Sippel LM, Watkins LE, Pietrzak RH, Hoff R, Harpaz-Rotem I. The Unique Roles of Emotional Numbing and Arousal Symptoms in Relation to Social Connectedness Among Military Veterans in Residential Treatment for PTSD. Psychiatry 2018, 81: 271-282. PMID: 30015602, DOI: 10.1080/00332747.2017.1395313.Peer-Reviewed Original ResearchConceptsPTSD symptom clustersDysphoric arousal symptomsPoor social connectednessArousal symptomsEmotional numbingSocial connectednessResidential treatmentPosttraumatic stress disorder (PTSD) symptomsSymptom clustersEmotional numbing symptomsMilitary veteransAnxious arousal symptomsFive-factor modelU.S. military veteransAnxious arousalDysphoric arousalNumbing symptomsInterpersonal functioningTrauma recoveryDisorder symptomsCase conceptualizationGreater distressMore distressPTSDSupportive people
2017
Differential predictive value of PTSD symptom clusters for mental health care among Iraq and Afghanistan veterans following PTSD diagnosis
Smith NB, Tsai J, Pietrzak RH, Cook JM, Hoff R, Harpaz-Rotem I. Differential predictive value of PTSD symptom clusters for mental health care among Iraq and Afghanistan veterans following PTSD diagnosis. Psychiatry Research 2017, 256: 32-39. PMID: 28622572, DOI: 10.1016/j.psychres.2017.06.005.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAfghanistan veteransPTSD symptom clustersNational VA administrative dataVeterans AffairsSymptom clustersMental health service utilizationTreatment-related variablesHealth service utilizationVA administrative dataSelection of treatmentMental health carePTSD symptom cluster severitySymptom cluster severityTrauma-exposed veteransInitial diagnosisClinical variablesPsychotherapy visitsAdequate doseService utilizationDifferential predictive valueLarge cohortCombination treatmentPsychotherapy initiationTreatment approaches
2016
Co-occurring aggression and suicide attempt among veterans entering residential treatment for PTSD: The role of PTSD symptom clusters and alcohol misuse
Watkins LE, Sippel LM, Pietrzak RH, Hoff R, Harpaz-Rotem I. Co-occurring aggression and suicide attempt among veterans entering residential treatment for PTSD: The role of PTSD symptom clusters and alcohol misuse. Journal Of Psychiatric Research 2016, 87: 8-14. PMID: 27984702, DOI: 10.1016/j.jpsychires.2016.12.009.Peer-Reviewed Original ResearchConceptsSuicide attemptsAlcohol misuseU.S. veteransSymptom clustersPTSD symptom clustersVeterans Health Administration sitesSerious public health concernPTSD re-experiencing symptomsResidential treatmentDysphoric arousal symptomsPublic health concernCo-occurring aggressionLogistic regression modelsMultinomial logistic regression modelsPosttraumatic stress disorder (PTSD) symptom clustersRisk factorsRe-experiencing symptomsCorrelates of aggressionAdministration siteHealth concernMisuse symptomsSymptomsArousal symptomsTreatment planningVeteransInitiation of pharmacotherapy for post-traumatic stress disorder among veterans from Iraq and Afghanistan: a dimensional, symptom cluster approach
Harpaz-Rotem I, Rosenheck R, Mohamed S, Pietrzak R, Hoff R. Initiation of pharmacotherapy for post-traumatic stress disorder among veterans from Iraq and Afghanistan: a dimensional, symptom cluster approach. BJPsych Open 2016, 2: 286-293. PMID: 27703791, PMCID: PMC5016711, DOI: 10.1192/bjpo.bp.115.002451.Peer-Reviewed Original ResearchPost-traumatic stress disorderAnxiolytics/sedatives/hypnoticsPTSD diagnosisUS Veterans Health AdministrationPhenotypic presentationInitiation of pharmacotherapyPrescription of antidepressantsSedative/hypnoticsVeterans Health AdministrationHeterogeneous phenotypic presentationsMilitary-related post-traumatic stress disorderHypnotic prescriptionsMedication classesPrescribing patternsFirst prescriptionMultivariable analysisPharmacological treatmentClinical guidelinesInitial episodeUS veteransPTSD symptom clustersRe-experiencing symptomsSleep difficultiesHealth AdministrationSymptom clusters
2014
Functional significance of a novel 7-factor model of DSM-5 PTSD symptoms: Results from the National Health and Resilience in Veterans Study
Pietrzak RH, Tsai J, Armour C, Mota N, Harpaz-Rotem I, Southwick SM. Functional significance of a novel 7-factor model of DSM-5 PTSD symptoms: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2014, 174: 522-526. PMID: 25556669, DOI: 10.1016/j.jad.2014.12.007.Peer-Reviewed Original ResearchConceptsQuality of lifePosttraumatic stress disorderDSM-5 PTSD symptomsPTSD symptomsNational HealthU.S. veteransSuicidal ideationVeterans StudySymptom clustersDysphoric arousal symptomsCross-sectional designFunctional outcomePsychiatric comorbidityClinical significancePTSD symptom clustersCurrent depressionDSM-5 PTSD symptom clustersPTSD phenotypeMental disordersSymptomsComorbid psychopathologyStress disorderFunctional correlatesStatistical ManualTreatment effortsDimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study.
Tsai J, Harpaz-Rotem I, Armour C, Southwick SM, Krystal JH, Pietrzak RH. Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2014, 76: 546-53. PMID: 25562376, DOI: 10.4088/jcp.14m09091.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLifetime posttraumatic stress disorderHealth-related functioningMental health-related functioningDSM-5 posttraumatic stress disorderUS veteransSymptom clustersPTSD symptom clustersNational HealthVeterans StudyPTSD symptomsQuality of lifeDysphoric Arousal modelPosttraumatic stress disorder (PTSD) symptomsDSM-5 posttraumatic stress disorder symptomsDSM-5 PTSD symptom clustersHealth outcomesFemale veteransSuicidal ideationDSM-5 PTSD symptomsStress disorderSymptomsDisorder symptomsPTSD symptomatologyVeterans
2011
Support for a novel five-factor model of posttraumatic stress symptoms in three independent samples of Iraq/Afghanistan veterans: A confirmatory factor analytic study
Pietrzak RH, Tsai J, Harpaz-Rotem I, Whealin JM, Southwick SM. Support for a novel five-factor model of posttraumatic stress symptoms in three independent samples of Iraq/Afghanistan veterans: A confirmatory factor analytic study. Journal Of Psychiatric Research 2011, 46: 317-322. PMID: 22154134, DOI: 10.1016/j.jpsychires.2011.11.013.Peer-Reviewed Original ResearchConceptsIraq/Afghanistan veteransHyperarousal symptom clustersConfirmatory factor analytic studyFactor analytic studiesAfghanistan veteransDysphoric arousalPTSD symptomsArousal clustersCommunity samplePosttraumatic stress disorder (PTSD) symptomsEmotional numbing modelSymptom clustersTreatment-seeking samplePosttraumatic stress symptomsDSM-IV modelIndependent samplesFive-factor modelConfirmatory factor analysisAnxious arousalEmotional numbingNumbing modelPTSD symptomatologyDisorder symptomsStress symptomsPTSD Checklist