2024
To Expose or Not to Expose: A Comprehensive Perspective on Treatment for Posttraumatic Stress Disorder
Rubenstein A, Duek O, Doran J, Harpaz-Rotem I. To Expose or Not to Expose: A Comprehensive Perspective on Treatment for Posttraumatic Stress Disorder. American Psychologist 2024, 79: 331-343. PMID: 38635195, PMCID: PMC11034887, DOI: 10.1037/amp0001121.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderTreating posttraumatic stress disorderNon-trauma-focused treatmentsExposure therapyStress disorderTreatment of posttraumatic stress disorderNon-trauma-focused therapiesPosttraumatic stress disorder diagnosisSelf-directed exposureTrauma-focused psychotherapyPsychotherapy factorsTrauma memoriesTrauma-focusedBehavioral paradigmsSymptom remissionHigh dropout ratesTherapy processTherapy contextProlonged exposurePsychotherapyDropout ratesIncreased patient autonomyResearch literatureDisordersClinical researchWhat Happens Next? Maintenance of Gains After Discharge From VA Residential PTSD Treatment
Grau P, Harpaz-Rotem I, Ilgen M, Ganoczy D, Sripada R. What Happens Next? Maintenance of Gains After Discharge From VA Residential PTSD Treatment. The Journal Of Nervous And Mental Disease 2024, 212: 197-204. PMID: 38536046, DOI: 10.1097/nmd.0000000000001749.Peer-Reviewed Original ResearchConceptsMaintenance of gainsResidential PTSD treatmentPosttraumatic stress disorderPTSD treatmentStress disorderResidential treatmentSymptom reboundDepartment of Veterans AffairsCohort of veteransSignificant respondersTreatment responseNational cohort of veteransVeteransAssociated with maintenanceResponse profilesPain severityVeterans AffairsGreater pain severitySessionsAssociated with decreased oddsPsychotherapyAssociated with increased oddsSeverityDisordersRespondents
2022
Post-traumatic Stress Disorder
Merians A, Spiller T, Harpaz-Rotem I, Krystal J, Pietrzak R. Post-traumatic Stress Disorder. Medical Clinics Of North America 2022, 107: 85-99. PMID: 36402502, DOI: 10.1016/j.mcna.2022.04.003.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderStress disorderCognitive processing therapyCognitive behavioral therapyEye movement desensitizationEvidence-based psychotherapiesTraumatic eventsBehavioral therapyNegative alterationsFirst-line pharmacologic treatmentStructured interviewsFirst-line treatmentNonpsychiatric settingsLarge bodyPharmacologic treatmentReuptake inhibitorsCognitionDisordersArousalTherapeutic interventionsMoodPsychotherapyAvoidanceTherapyIntervention
2019
Adoption by VA Residential Programs of Two Evidence-Based Psychotherapies for PTSD: Effect on Patient Outcomes
Cook JM, Schnurr PP, Simiola V, Thompson R, Hoff R, Harpaz-Rotem I. Adoption by VA Residential Programs of Two Evidence-Based Psychotherapies for PTSD: Effect on Patient Outcomes. Psychiatric Services 2019, 70: 553-560. PMID: 30966944, PMCID: PMC6690369, DOI: 10.1176/appi.ps.201800338.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyComorbidityDepressionFemaleHumansImplosive TherapyMaleMiddle AgedOutcome and Process Assessment, Health CarePsychological DistressResidential TreatmentStress Disorders, Post-TraumaticSubstance-Related DisordersUnited StatesUnited States Department of Veterans AffairsVeteransConceptsPosttraumatic stress disorderCognitive processing therapyEvidence-based psychotherapiesVeterans Affairs residential treatment programsAdoption groupsAlcohol useResidential treatment programSample of veteransGroup × time interactionPTSD symptomsStress disorderGroup formatProgram intakeResidential programs× time interactionDepression symptomsTreatment programPsychotherapyBasis of responsesPatient outcomesTime interactionProgram dischargeQualitative interviewsMonths postdischargeVeterans
2017
Fear extinction and memory reconsolidation as critical components in behavioral treatment for posttraumatic stress disorder and potential augmentation of these processes
Smith NB, Doran JM, Sippel LM, Harpaz-Rotem I. Fear extinction and memory reconsolidation as critical components in behavioral treatment for posttraumatic stress disorder and potential augmentation of these processes. Neuroscience Letters 2017, 649: 170-175. PMID: 28065842, DOI: 10.1016/j.neulet.2017.01.006.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderReconsolidation processPTSD psychotherapyStress disorderBehavioral treatmentExposure-based treatmentsCritical brain regionsFear extinctionMemory reconsolidationTraumatic memoriesImportant future directionsPTSD populationsPTSD therapyNeurobiological mechanismsPrefrontal cortexReconsolidationBrain regionsPsychotherapyProcess of extinctionMemoryPotential avenuesFuture directionsBehavioral modificationExtinctionDisorders
2011
FC16-06 - Understanding pathways to therapeutic change through changes in self-representation in the treatment of adolescents and young adults
Harpaz-Rotem I, Blatt S. FC16-06 - Understanding pathways to therapeutic change through changes in self-representation in the treatment of adolescents and young adults. European Psychiatry 2011, 26: 1909. DOI: 10.1016/s0924-9338(11)73613-6.Peer-Reviewed Original ResearchYoung adultsTherapeutic changeTherapeutic relationshipRepresentations of selfExploratory structural equation modelingCourse of psychotherapyTreatment of adolescentsStructural equation modelingInterpersonal exchangesInterpersonal relationshipsIntegrated representationEquation modelingPsychodynamic psychotherapyOverall levelClinical functioningAdolescentsPsychotherapySelfTherapistsGAF scores