2023
Evaluating a novel 8-factor dimensional model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Stiltner B, Fischer I, Duek O, Polimanti R, Harpaz-Rotem I, Pietrzak R. Evaluating a novel 8-factor dimensional model of PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Journal Of Affective Disorders 2023, 346: 303-307. PMID: 37979626, DOI: 10.1016/j.jad.2023.11.041.Peer-Reviewed Original ResearchConceptsIndex traumaPTSD symptomsNational HealthPosttraumatic stress disorder (PTSD) symptomsVeterans StudyMilitary veteransTrauma-exposed populationsClinician-administered interviewU.S. military veteransConfirmatory factor analysisDSM-5 modelStrong significant associationTrauma exposureIntrusive symptomsDisorder symptomsCombat exposureHigh riskU.S. veteransDSM-5Significant associationSymptomsInterpersonal violenceFactor analysisPTSDScarce research
2020
Sex Differences in Associations Between Depression and Posttraumatic Stress Disorder Symptoms and Tobacco Use Among Veterans of Recent Conflicts
Gross GM, Bastian LA, Smith NB, Harpaz-Rotem I, Hoff R. Sex Differences in Associations Between Depression and Posttraumatic Stress Disorder Symptoms and Tobacco Use Among Veterans of Recent Conflicts. Journal Of Women's Health 2020, 29: 677-685. PMID: 31934813, DOI: 10.1089/jwh.2019.8082.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderTobacco usePTSD symptomsFemale veteransSex differencesAssociation of depressionTobacco use cessationBaseline interview dataCross-sectional associationsMental health conditionsLogistic regression modelsPosttraumatic stress disorder (PTSD) symptomsBinary logistic regression modelSex-specific barriersTobacco usersSymptomsStress disorderAlcohol useHealth conditionsDepressionDisorder symptomsVeteran sampleMH conditionsIntervention strategiesEffects of demographics
2019
Posttraumatic Stress Disorder Symptoms, Functioning, and Suicidal Ideation in US Military Veterans: A Symptomics Approach.
Kachadourian LK, Harpaz-Rotem I, Tsai J, Southwick SM, Pietrzak RH. Posttraumatic Stress Disorder Symptoms, Functioning, and Suicidal Ideation in US Military Veterans: A Symptomics Approach. The Primary Care Companion For CNS Disorders 2019, 21 PMID: 31050228, DOI: 10.4088/pcc.18m02402.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPositive affectMeasures of functioningCognitive functioningNegative thoughtsPTSD symptomsConcentration difficultiesSleep difficultiesTreatment of PTSDUS military veteransSeverity of PTSDPosttraumatic stress disorder (PTSD) symptomsSuicidal ideationDSM-5 PTSD symptomsMilitary veteransLifetime trauma burdenIrritability/aggressionHyperarousal symptomsDisorder symptomsStress disorderPsychogenic amnesiaPTSD diagnosisQuality of lifeMental functioningMost varianceNeural computations of threat in the aftermath of combat trauma
Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience 2019, 22: 470-476. PMID: 30664770, PMCID: PMC6829910, DOI: 10.1038/s41593-018-0315-x.Peer-Reviewed Original ResearchConceptsPTSD symptomsPost-traumatic stress disorder symptomsHigher PTSD symptom severityThreat-predictive cuesPTSD symptom severityAssociative threatPredictive cuesNeural trackingDisorder symptomsPrediction errorCombat veteransDynamic learning rateNegative outcomesCombat traumaSmaller amygdala volumesNeural computationLatent markersSymptomatic veteransSymptom severityAmygdala volumeAssociabilityCuesLearning rateVeteransSymptoms
2018
The Unique Roles of Emotional Numbing and Arousal Symptoms in Relation to Social Connectedness Among Military Veterans in Residential Treatment for PTSD
Sippel LM, Watkins LE, Pietrzak RH, Hoff R, Harpaz-Rotem I. The Unique Roles of Emotional Numbing and Arousal Symptoms in Relation to Social Connectedness Among Military Veterans in Residential Treatment for PTSD. Psychiatry 2018, 81: 271-282. PMID: 30015602, DOI: 10.1080/00332747.2017.1395313.Peer-Reviewed Original ResearchConceptsPTSD symptom clustersDysphoric arousal symptomsPoor social connectednessArousal symptomsEmotional numbingSocial connectednessResidential treatmentPosttraumatic stress disorder (PTSD) symptomsSymptom clustersEmotional numbing symptomsMilitary veteransAnxious arousal symptomsFive-factor modelU.S. military veteransAnxious arousalDysphoric arousalNumbing symptomsInterpersonal functioningTrauma recoveryDisorder symptomsCase conceptualizationGreater distressMore distressPTSDSupportive peopleClinically Significant Change in Posttraumatic Stress Disorder Symptoms Is Associated With Lower Levels of Aggression After Residential Treatment Discharge
Watkins LE, Sippel LM, Pietrzak RH, Hoff R, Harpaz‐Rotem I. Clinically Significant Change in Posttraumatic Stress Disorder Symptoms Is Associated With Lower Levels of Aggression After Residential Treatment Discharge. Journal Of Traumatic Stress 2018, 31: 265-272. PMID: 29603388, DOI: 10.1002/jts.22275.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPTSD symptomsPTSD changeResidential treatmentPosttraumatic stress disorder (PTSD) symptomsLess aggressionPTSD symptom changePTSD symptom reductionCurrent studyDisorder symptomsStress disorderContextual effectsSymptom reductionSymptom changeAggressionMultilevel modelsPrevious researchTreatment dischargeLow levelsVeterans Health Administration sitesVeteransSignificant changesTreatment sitesFindingsSymptoms
2017
Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD
Wrocklage KM, Averill LA, Scott J, Averill CL, Schweinsburg B, Trejo M, Roy A, Weisser V, Kelly C, Martini B, Harpaz-Rotem I, Southwick SM, Krystal JH, Abdallah CG. Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD. European Neuropsychopharmacology 2017, 27: 515-525. PMID: 28279623, PMCID: PMC5429865, DOI: 10.1016/j.euroneuro.2017.02.010.Peer-Reviewed Original ResearchConceptsClinician-Administered PTSD ScalePTSD symptom dimensionsPTSD diagnosisCombat exposureCortical thicknessSymptom dimensionsMagnetic resonance imagingPosttraumatic stress disorder (PTSD) symptomsU.S. veteransCortical thinningUnique brain regionsLeft lateral prefrontalAnxious arousalPTSD dimensionsNeural correlatesHigh-resolution magnetic resonance imagingCortical thickness reductionsLateral prefrontalPTSD symptomsDisorder symptomsCombat severityCurrent PTSDPTSD ScalePrefrontal cortexPotential confounds
2014
Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study.
Tsai J, Harpaz-Rotem I, Armour C, Southwick SM, Krystal JH, Pietrzak RH. Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2014, 76: 546-53. PMID: 25562376, DOI: 10.4088/jcp.14m09091.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLifetime posttraumatic stress disorderHealth-related functioningMental health-related functioningDSM-5 posttraumatic stress disorderUS veteransSymptom clustersPTSD symptom clustersNational HealthVeterans StudyPTSD symptomsQuality of lifeDysphoric Arousal modelPosttraumatic stress disorder (PTSD) symptomsDSM-5 posttraumatic stress disorder symptomsDSM-5 PTSD symptom clustersHealth outcomesFemale veteransSuicidal ideationDSM-5 PTSD symptomsStress disorderSymptomsDisorder symptomsPTSD symptomatologyVeterans
2011
Support for a novel five-factor model of posttraumatic stress symptoms in three independent samples of Iraq/Afghanistan veterans: A confirmatory factor analytic study
Pietrzak RH, Tsai J, Harpaz-Rotem I, Whealin JM, Southwick SM. Support for a novel five-factor model of posttraumatic stress symptoms in three independent samples of Iraq/Afghanistan veterans: A confirmatory factor analytic study. Journal Of Psychiatric Research 2011, 46: 317-322. PMID: 22154134, DOI: 10.1016/j.jpsychires.2011.11.013.Peer-Reviewed Original ResearchConceptsIraq/Afghanistan veteransHyperarousal symptom clustersConfirmatory factor analytic studyFactor analytic studiesAfghanistan veteransDysphoric arousalPTSD symptomsArousal clustersCommunity samplePosttraumatic stress disorder (PTSD) symptomsEmotional numbing modelSymptom clustersTreatment-seeking samplePosttraumatic stress symptomsDSM-IV modelIndependent samplesFive-factor modelConfirmatory factor analysisAnxious arousalEmotional numbingNumbing modelPTSD symptomatologyDisorder symptomsStress symptomsPTSD Checklist
2009
Assessing the Effects of Maternal Symptoms and Homelessness on the Mental Health Problems in their Children
Harpaz‐Rotem I, Rosenheck R, Desai R. Assessing the Effects of Maternal Symptoms and Homelessness on the Mental Health Problems in their Children. Child And Adolescent Mental Health 2009, 14: 168-174. DOI: 10.1111/j.1475-3588.2008.00519.x.Peer-Reviewed Original ResearchChild mental healthMental healthMaternal posttraumatic stress disorder symptomsPosttraumatic stress disorder (PTSD) symptomsMaternal PTSD symptomsMeasures of childMaternal psychiatric symptomsPsychiatric symptomsMental health problemsPTSD symptomsDisorder symptomsTraumatic experiencesAnxiety symptomsLongitudinal associationsSubstance abuseAnalytic strategiesChild wellMaternal symptomsPsychiatric conditionsProgram entryChildrenDepressionPTSDMothersHealth problems