2023
The fat and the flow: multiparametric imaging assessment of pericoronary adipose tissue and myocardial blood flow
Csecs I, Feher A. The fat and the flow: multiparametric imaging assessment of pericoronary adipose tissue and myocardial blood flow. Journal Of Nuclear Cardiology 2023, 30: 1570-1573. PMID: 36929294, DOI: 10.1007/s12350-023-03247-x.Peer-Reviewed Original ResearchDoes Coronary Plaque Morphology Matter Beyond Plaque Burden?
Lorenzatti D, Piña P, Csecs I, Schenone A, Gongora C, Garcia M, Blaha M, Budoff M, Williams M, Dey D, Berman D, Virani S, Slipczuk L. Does Coronary Plaque Morphology Matter Beyond Plaque Burden? Current Atherosclerosis Reports 2023, 25: 167-180. PMID: 36808390, DOI: 10.1007/s11883-023-01088-0.Peer-Reviewed Original ResearchConceptsCoronary computed tomography angiographyMedical therapyPlaque burdenResponse to medical therapyPlaque analysisCoronary plaquesAssessment of coronary plaquesHigh-risk phenotypePreventive medical therapyAdverse cardiovascular eventsCoronary plaque featuresRandomized controlled trialsPericoronary inflammationMyocardial infarction typeCardiovascular eventsDisease progressionRisk phenotypesCulprit plaquesControlled trialsPlaque characteristicsPlaque featuresTherapySummaryThe identificationTracking disease progressionInfarct type
2022
Potential clinical relevance of cardiac magnetic resonance to diagnose cardiac light chain amyloidosis
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. Potential clinical relevance of cardiac magnetic resonance to diagnose cardiac light chain amyloidosis. PLOS ONE 2022, 17: e0269807. PMID: 35696411, PMCID: PMC9191721, DOI: 10.1371/journal.pone.0269807.Peer-Reviewed Original ResearchConceptsCardiac AL amyloidosisCardiac magnetic resonanceLate gadolinium enhancementAL amyloidosisOptimal diagnostic performanceHypertrophic cardiomyopathyDegree of left ventricular (LV) hypertrophyReduced global LV longitudinal strainDiagnostic performanceLeft ventricular (LV) hypertrophyPattern of late gadolinium enhancementGlobal LV longitudinal strainSubendocardial late gadolinium enhancementCardiac magnetic resonance examinationCardiac magnetic resonance parametersCardiac light-chain amyloidosisDifferential diagnosis of cardiomyopathyLV strain parametersCardiac transthyretin amyloidosisLV) hypertrophyLV longitudinal strainDiagnosis of cardiomyopathyLight chain amyloidosisCardiac light chainsPotential clinical relevanceReference CMR values of atrial size and function: Are they similar in the east and the west?
Csecs I, Garcia M. Reference CMR values of atrial size and function: Are they similar in the east and the west? International Journal Of Cardiology 2022, 358: 134-135. PMID: 35483479, DOI: 10.1016/j.ijcard.2022.02.036.Peer-Reviewed Original ResearchAn Explainable Machine Learning Approach Reveals Prognostic Significance of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy
Fahmy A, Csecs I, Arafati A, Assana S, Yankama T, Al-Otaibi T, Rodriguez J, Chen Y, Ngo L, Manning W, Kwong R, Nezafat R. An Explainable Machine Learning Approach Reveals Prognostic Significance of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy. JACC Cardiovascular Imaging 2022, 15: 766-779. PMID: 35033500, DOI: 10.1016/j.jcmg.2021.11.029.Peer-Reviewed Original ResearchConceptsNonischemic dilated cardiomyopathyBeth Israel Deaconess Medical CenterComposite endpointRight ventricular (RV) dysfunctionCardiovascular hospitalizationRisk prediction modelAdverse outcomesRisk markersMarker of adverse outcomeCardiac magnetic resonance markersRisk stratification of patientsRight ventricular dysfunctionRV ejection fractionMedical CenterFollow-up durationCardiac magnetic resonanceEnd-diastolic volumeStratification of patientsArea under the curveAll-cause deathHigh-risk thresholdVentricular dysfunctionEjection fractionNonischemic cardiomyopathyPrognostic significance
2021
Benchmarking off-the-shelf statistical shape modeling tools in clinical applications
Goparaju A, Iyer K, Bône A, Hu N, Henninger H, Anderson A, Durrleman S, Jacxsens M, Morris A, Csecs I, Marrouche N, Elhabian S. Benchmarking off-the-shelf statistical shape modeling tools in clinical applications. Medical Image Analysis 2021, 76: 102271. PMID: 34974213, PMCID: PMC8792348, DOI: 10.1016/j.media.2021.102271.Peer-Reviewed Original ResearchConceptsStatistical shape modelShape modelPopulation-level variabilityDevelopment of open-source computational toolsAnalysis of anatomical shapesEvaluating shape modelsSurface correspondenceQualitative metricsSPHARM-PDMMorphometric approachOpen-source computational toolsValidation frameworkGroupwise approachClinical applicationModeling toolsLevel of consistencyPopulation-level statisticsDeformetricaCharacterization of Aerosol Generation During Various Intensities of Exercise
Sajgalik P, Garzona-Navas A, Csécs I, Askew J, Lopez-Jimenez F, Niven A, Johnson B, Allison T. Characterization of Aerosol Generation During Various Intensities of Exercise. CHEST Journal 2021, 160: 1377-1387. PMID: 33957100, PMCID: PMC8473677, DOI: 10.1016/j.chest.2021.04.041.Peer-Reviewed Original ResearchConceptsHeart rate reserveRate reservePredicted heart rate reserveExercise testSafety of exercise testingPeak respiratory exchange ratioIntensity of exercisePeak heart rateRespiratory exchange ratioStages of exerciseExercise intensityExercise activitiesMaximal ventilationExchange ratioExerciseAerosol-generating proceduresActivity recoveryStatistically significant increaseSafety recommendationsHealthy volunteersFace of COVID-19Heart rateSignificant increaseRecommendationsCOVID-19Mitigation of Aerosols Generated During Exercise Testing With a Portable High-Efficiency Particulate Air Filter With Fume Hood
Garzona-Navas A, Sajgalik P, Csécs I, Askew J, Lopez-Jimenez F, Niven A, Johnson B, Allison T. Mitigation of Aerosols Generated During Exercise Testing With a Portable High-Efficiency Particulate Air Filter With Fume Hood. CHEST Journal 2021, 160: 1388-1396. PMID: 33895130, PMCID: PMC8463654, DOI: 10.1016/j.chest.2021.04.023.Peer-Reviewed Original ResearchConceptsExercise testing laboratoryPortable HEPA filterExercise testPortable high-efficiency particulate airAerosol concentrationsClearance timeConcentration of aerosolsExercise experienceStationary cyclingRisk of COVID-19 transmissionExerciseActivity recoveryHealthy volunteersAerosolQuiet breathingAerosol mitigationParticle counterAerosol clearanceClearance experimentsCOVID-19 pandemicCOVID-19 transmissionParticle concentrationLarger particlesCOVID-19Machine learning phenotyping of scarred myocardium from cine in hypertrophic cardiomyopathy
Mancio J, Pashakhanloo F, El-Rewaidy H, Jang J, Joshi G, Csecs I, Ngo L, Rowin E, Manning W, Maron M, Nezafat R. Machine learning phenotyping of scarred myocardium from cine in hypertrophic cardiomyopathy. European Heart Journal - Cardiovascular Imaging 2021, 23: 532-542. PMID: 33779725, PMCID: PMC9125682, DOI: 10.1093/ehjci/jeab056.Peer-Reviewed Original ResearchSensitivity of Myocardial Radiomic Features to Imaging Parameters in Cardiac MR Imaging
Jang J, El‐Rewaidy H, Ngo L, Mancio J, Csecs I, Rodriguez J, Pierce P, Goddu B, Neisius U, Manning W, Nezafat R. Sensitivity of Myocardial Radiomic Features to Imaging Parameters in Cardiac MR Imaging. Journal Of Magnetic Resonance Imaging 2021, 54: 787-794. PMID: 33650227, PMCID: PMC9190024, DOI: 10.1002/jmri.27581.Peer-Reviewed Original ResearchConceptsRadiomic featuresIn-plane spatial resolutionImaging parametersSpatial resolutionBalanced steady-state free precessionCardiac magnetic resonanceIn-plane resolutionStandardized mean differenceSteady-state free precessionParallel imaging techniquesFlip angleCardiac MRCardiac MR imagesFree precessionMean differenceSlice thicknessMR imagingMagnetic resonanceCalculated valuesMyocardial contoursSequence parametersImaging techniquesWavelet filters
2020
Association Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy
Csecs I, Pashakhanloo F, Paskavitz A, Jang J, Al‐Otaibi T, Neisius U, Manning W, Nezafat R. Association Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy. Journal Of The American Heart Association 2020, 9: e016797. PMID: 33006296, PMCID: PMC7792406, DOI: 10.1161/jaha.120.016797.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementSeptal late gadolinium enhancementLV ejection fractionNonischemic cardiomyopathyExtent of fibrosisCardiovascular magnetic resonanceEjection fractionImpaired global circumferential strainImpaired LV ejection fractionLate gadolinium enhancement groupsDepressed LV ejection fractionClinical cardiovascular magnetic resonanceLeft ventricular (LVLGE-negative groupCircumferential strainGlobal radial strainGlobal longitudinal strainRadial strainGlobal circumferential strainLV deformation parametersGlobal LV functionAdverse cardiovascular outcomesLGE-positiveNonischemic fibrosisFibrosis burdenMulti‐domain convolutional neural network (MD‐CNN) for radial reconstruction of dynamic cardiac MRI
El‐Rewaidy H, Fahmy A, Pashakhanloo F, Cai X, Kucukseymen S, Csecs I, Neisius U, Haji‐Valizadeh H, Menze B, Nezafat R. Multi‐domain convolutional neural network (MD‐CNN) for radial reconstruction of dynamic cardiac MRI. Magnetic Resonance In Medicine 2020, 85: 1195-1208. PMID: 32924188, DOI: 10.1002/mrm.28485.Peer-Reviewed Original ResearchConceptsStructural similarity indexMulti-domain convolutional neural networkMean-squared-errorConvolutional neural networkMD-CNNNeural networkDynamic cardiac MRIComplex-valued networksCardiac MR cine imagesK-space interpolationProcessing MR dataImage domainTemporal fidelityUndersampled datasetsFast reconstructionCine imagesK-spaceArtifact suppressionMR cine imagesSimilarity indexCine dataBorder sharpnessNetworkLong scan timesNon-sinus rhythmHigh-intensity endurance training is associated with left atrial fibrosis
Peritz D, Catino A, Csecs I, Kaur G, Kheirkhahan M, Loveless B, Wasmund S, Kholmovski E, Morris A, Marrouche N. High-intensity endurance training is associated with left atrial fibrosis. American Heart Journal 2020, 226: 206-213. PMID: 32615358, DOI: 10.1016/j.ahj.2020.05.015.Peer-Reviewed Original ResearchConceptsEndurance athletesMaster athletesHigh-intensity endurance trainingTrained endurance athletesNon-athlete controlsHealthy control subjectsLeft atrial fibrosisScreening colonoscopyEndurance trainingAthletic cohortHealthcare complexityAtrial fibrosisAthletesStudy participantsControl subjectsGeneral populationEnduranceQuantify fibrotic changesLeft atrial volumeIncreased atrial fibrosisLeft ventricular functionParticipantsAtrial volumeGadolinium enhancementFibrosis scoreMagnetic resonance imaging–guided cryoballoon ablation for left atrial substrate modification in patients with atrial fibrillation
Kirstein B, Morris A, Baher A, Csécs I, Kheirkhahan M, Kaur G, Kholmovski E, Marrouche N. Magnetic resonance imaging–guided cryoballoon ablation for left atrial substrate modification in patients with atrial fibrillation. Journal Of Cardiovascular Electrophysiology 2020, 31: 1587-1594. PMID: 32412119, DOI: 10.1111/jce.14551.Peer-Reviewed Original ResearchConceptsPulmonary vein isolationCryoballoon ablationLGE-MRIAtrial fibrillationFirst-time AF ablationGadolinium-enhanced magnetic resonance imagingTreatment of atrial fibrillationLA substrateLate gadolinium enhancement magnetic resonance imagingEnhanced magnetic resonance imagingEsophageal thermal injuryAtrial substrate modificationMagnetic resonance imagingVein isolationAF recurrenceAF ablationPulmonary veinsPeriprocedural dataLA scarRhythm monitoringSubstrate modificationResonance imagingThermal injuryCryoballoonPostablationHow are ECG parameters related to cardiac magnetic resonance images? Electrocardiographic predictors of left ventricular hypertrophy and myocardial fibrosis in hypertrophic cardiomyopathy
Dohy Z, Vereckei A, Horvath V, Czimbalmos C, Szabo L, Toth A, Suhai F, Csecs I, Becker D, Merkely B, Vago H. How are ECG parameters related to cardiac magnetic resonance images? Electrocardiographic predictors of left ventricular hypertrophy and myocardial fibrosis in hypertrophic cardiomyopathy. Annals Of Noninvasive Electrocardiology 2020, 25: e12763. PMID: 32329134, PMCID: PMC7507346, DOI: 10.1111/anec.12763.Peer-Reviewed Original ResearchConceptsRomhilt-Estes scoreLeft ventricular hypertrophyCardiac magnetic resonance imagingFragmented QRSSokolow-Lyon indexHypertrophic cardiomyopathyMyocardial fibrosisCornell indexMagnetic resonance imagingVentricular hypertrophyRepolarization abnormalitiesPredictor of myocardial fibrosisElectrocardiographic parametersPresence of fragmented QRSLeft ventricular ejection fractionDetectable left ventricular hypertrophyElectrocardiographic voltage criteriaResonance imagingVentricular ejection fractionHypertrophic cardiomyopathy patientsStructural myocardial changesDegree of myocardial fibrosisPathologic Q wavesAmount of fibrosisEjection fractionLeft atrial fibrosis progression detected by LGE‐MRI after ablation of atrial fibrillation
Kheirkhahan M, Baher A, Goldooz M, Kholmovski E, Morris A, Csecs I, Chelu M, Wilson B, Marrouche N. Left atrial fibrosis progression detected by LGE‐MRI after ablation of atrial fibrillation. Pacing And Clinical Electrophysiology 2020, 43: 402-411. PMID: 31867751, DOI: 10.1111/pace.13866.Peer-Reviewed Original ResearchConceptsAF recurrenceAF ablationLGE-MRIAtrial fibrillationLong-term procedural outcomesGadolinium-enhanced magnetic resonance imagingAssociated with significantly higher riskArrhythmia-free survivalAtrial arrhythmia recurrencePostablation AF recurrenceLate gadolinium enhancement magnetic resonance imagingEnhanced magnetic resonance imagingFollow-up periodSignificantly higher riskCardiovascular risk factorsMagnetic resonance imagingMonths postablationArrhythmia recurrenceConsecutive patientsLA fibrosisAblation proceduresFibrosis progressionProcedural outcomesAblation lesionsRecurrence
2019
Left atrial functional and structural changes associated with ablation of atrial fibrillation - Cardiac magnetic resonance study
Csécs I, Yamaguchi T, Kheirkhahan M, Czimbalmos C, Fochler F, Kholmovski E, Morris A, Kaur G, Vago H, Merkely B, Chelu M, Marrouche N, Wilson B. Left atrial functional and structural changes associated with ablation of atrial fibrillation - Cardiac magnetic resonance study. International Journal Of Cardiology 2019, 305: 154-160. PMID: 31874788, DOI: 10.1016/j.ijcard.2019.12.010.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonance imagingCardiac magnetic resonance studyLA-LGEPredictors of recurrenceLate gadolinium enhancementLA volumeAtrial fibrillationPredictor of arrhythmia recurrenceSuccess of AF ablationAssessment of LA functionSelection of optimal treatment strategiesSuccess of atrial fibrillationOptimal treatment strategyBaseline functional parametersAssociated with ablationMagnetic resonance imagingArrhythmia recurrenceAF ablationAF patientsAtrial functionLA functionPost-ablationUnivariate analysisTreatment strategiesRecurrenceBiventricular pacing during cardiac magnetic resonance imaging
Vago H, Czimbalmos C, Papp R, Szabo L, Toth A, Dohy Z, Csecs I, Suhai F, Kosztin A, Molnar L, Geller L, Merkely B. Biventricular pacing during cardiac magnetic resonance imaging. EP Europace 2019, 22: 117-124. PMID: 31713632, DOI: 10.1093/europace/euz289.Peer-Reviewed Original ResearchConceptsLV end-systolic volume indexLV ejection fractionLV end-diastolic volume indexNew York Heart AssociationCardiac magnetic resonance imagingCardiac magnetic resonanceRegional dyssynchronyBiventricular pacingAOO pacingMagnetic resonance imagingCMR parametersEffectiveness of resynchronization therapyLeft ventricular remodeling indexLeft ventricular (LV) functionCardiac magnetic resonance examinationEnd-diastolic volume indexEnd-systolic volume indexQuantification of LV functionVolume indexRemodeling indexConventional CMR parametersImprove responder rateResonance imagingOptimal medical therapyEffects of cardiac resynchronizationThe impact of sex, age and training on biventricular cardiac adaptation in healthy adult and adolescent athletes: Cardiac magnetic resonance imaging study
Csecs I, Czimbalmos C, Toth A, Dohy Z, Suhai I, Szabo L, Kovacs A, Lakatos B, Sydo N, Kheirkhahan M, Peritz D, Kiss O, Merkely B, Vago H. The impact of sex, age and training on biventricular cardiac adaptation in healthy adult and adolescent athletes: Cardiac magnetic resonance imaging study. European Journal Of Preventive Cardiology 2019, 27: 540-549. PMID: 31370686, DOI: 10.1177/2047487319866019.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAdolescentAdultAge FactorsAthletesCardiomegaly, Exercise-InducedFemaleHeart VentriclesHumansMagnetic Resonance Imaging, CineMalePhysical Conditioning, HumanPredictive Value of TestsSex FactorsVentricular Function, LeftVentricular Function, RightVentricular RemodelingYoung AdultConceptsEnd-diastolic volume indexVentricular mass indexTraining hoursBody surface areaTraining volumeEndurance sportsCardiac adaptationImpact of sexVentricular massMass indexMale sexRight ventricular end-diastolic volume indexHigher training volumeVentricular volumeLeft ventricular end-diastolic volume indexCardiac magnetic resonance parametersWeekly training hoursRight ventricular ejection fractionVolume indexLeft ventricular mass indexRight ventricular mass indexCardiac magnetic resonance imagingRight/left ventricular ratioVentricular ejection fractionEnd-systolic volumeCardiac Amyloidosis and Electrical Cardioversion Is the Thrombus There or Not?
Csecs I, Merkely B, Wilson B. Cardiac Amyloidosis and Electrical Cardioversion Is the Thrombus There or Not? Journal Of The American College Of Cardiology 2019, 73: 2909-2910. PMID: 31171103, DOI: 10.1016/j.jacc.2019.03.491.Peer-Reviewed Original Research