2022
Potential clinical relevance of cardiac magnetic resonance to diagnose cardiac light chain amyloidosis
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. Potential clinical relevance of cardiac magnetic resonance to diagnose cardiac light chain amyloidosis. PLOS ONE 2022, 17: e0269807. PMID: 35696411, PMCID: PMC9191721, DOI: 10.1371/journal.pone.0269807.Peer-Reviewed Original ResearchConceptsCardiac AL amyloidosisCardiac magnetic resonanceLate gadolinium enhancementAL amyloidosisOptimal diagnostic performanceHypertrophic cardiomyopathyDegree of left ventricular (LV) hypertrophyReduced global LV longitudinal strainDiagnostic performanceLeft ventricular (LV) hypertrophyPattern of late gadolinium enhancementGlobal LV longitudinal strainSubendocardial late gadolinium enhancementCardiac magnetic resonance examinationCardiac magnetic resonance parametersCardiac light-chain amyloidosisDifferential diagnosis of cardiomyopathyLV strain parametersCardiac transthyretin amyloidosisLV) hypertrophyLV longitudinal strainDiagnosis of cardiomyopathyLight chain amyloidosisCardiac light chainsPotential clinical relevance
2021
Machine learning phenotyping of scarred myocardium from cine in hypertrophic cardiomyopathy
Mancio J, Pashakhanloo F, El-Rewaidy H, Jang J, Joshi G, Csecs I, Ngo L, Rowin E, Manning W, Maron M, Nezafat R. Machine learning phenotyping of scarred myocardium from cine in hypertrophic cardiomyopathy. European Heart Journal - Cardiovascular Imaging 2021, 23: 532-542. PMID: 33779725, PMCID: PMC9125682, DOI: 10.1093/ehjci/jeab056.Peer-Reviewed Original Research
2020
High-intensity endurance training is associated with left atrial fibrosis
Peritz D, Catino A, Csecs I, Kaur G, Kheirkhahan M, Loveless B, Wasmund S, Kholmovski E, Morris A, Marrouche N. High-intensity endurance training is associated with left atrial fibrosis. American Heart Journal 2020, 226: 206-213. PMID: 32615358, DOI: 10.1016/j.ahj.2020.05.015.Peer-Reviewed Original ResearchConceptsEndurance athletesMaster athletesHigh-intensity endurance trainingTrained endurance athletesNon-athlete controlsHealthy control subjectsLeft atrial fibrosisScreening colonoscopyEndurance trainingAthletic cohortHealthcare complexityAtrial fibrosisAthletesStudy participantsControl subjectsGeneral populationEnduranceQuantify fibrotic changesLeft atrial volumeIncreased atrial fibrosisLeft ventricular functionParticipantsAtrial volumeGadolinium enhancementFibrosis scoreMagnetic resonance imaging–guided cryoballoon ablation for left atrial substrate modification in patients with atrial fibrillation
Kirstein B, Morris A, Baher A, Csécs I, Kheirkhahan M, Kaur G, Kholmovski E, Marrouche N. Magnetic resonance imaging–guided cryoballoon ablation for left atrial substrate modification in patients with atrial fibrillation. Journal Of Cardiovascular Electrophysiology 2020, 31: 1587-1594. PMID: 32412119, DOI: 10.1111/jce.14551.Peer-Reviewed Original ResearchConceptsPulmonary vein isolationCryoballoon ablationLGE-MRIAtrial fibrillationFirst-time AF ablationGadolinium-enhanced magnetic resonance imagingTreatment of atrial fibrillationLA substrateLate gadolinium enhancement magnetic resonance imagingEnhanced magnetic resonance imagingEsophageal thermal injuryAtrial substrate modificationMagnetic resonance imagingVein isolationAF recurrenceAF ablationPulmonary veinsPeriprocedural dataLA scarRhythm monitoringSubstrate modificationResonance imagingThermal injuryCryoballoonPostablationHow are ECG parameters related to cardiac magnetic resonance images? Electrocardiographic predictors of left ventricular hypertrophy and myocardial fibrosis in hypertrophic cardiomyopathy
Dohy Z, Vereckei A, Horvath V, Czimbalmos C, Szabo L, Toth A, Suhai F, Csecs I, Becker D, Merkely B, Vago H. How are ECG parameters related to cardiac magnetic resonance images? Electrocardiographic predictors of left ventricular hypertrophy and myocardial fibrosis in hypertrophic cardiomyopathy. Annals Of Noninvasive Electrocardiology 2020, 25: e12763. PMID: 32329134, PMCID: PMC7507346, DOI: 10.1111/anec.12763.Peer-Reviewed Original ResearchConceptsRomhilt-Estes scoreLeft ventricular hypertrophyCardiac magnetic resonance imagingFragmented QRSSokolow-Lyon indexHypertrophic cardiomyopathyMyocardial fibrosisCornell indexMagnetic resonance imagingVentricular hypertrophyRepolarization abnormalitiesPredictor of myocardial fibrosisElectrocardiographic parametersPresence of fragmented QRSLeft ventricular ejection fractionDetectable left ventricular hypertrophyElectrocardiographic voltage criteriaResonance imagingVentricular ejection fractionHypertrophic cardiomyopathy patientsStructural myocardial changesDegree of myocardial fibrosisPathologic Q wavesAmount of fibrosisEjection fractionLeft atrial fibrosis progression detected by LGE‐MRI after ablation of atrial fibrillation
Kheirkhahan M, Baher A, Goldooz M, Kholmovski E, Morris A, Csecs I, Chelu M, Wilson B, Marrouche N. Left atrial fibrosis progression detected by LGE‐MRI after ablation of atrial fibrillation. Pacing And Clinical Electrophysiology 2020, 43: 402-411. PMID: 31867751, DOI: 10.1111/pace.13866.Peer-Reviewed Original ResearchConceptsAF recurrenceAF ablationLGE-MRIAtrial fibrillationLong-term procedural outcomesGadolinium-enhanced magnetic resonance imagingAssociated with significantly higher riskArrhythmia-free survivalAtrial arrhythmia recurrencePostablation AF recurrenceLate gadolinium enhancement magnetic resonance imagingEnhanced magnetic resonance imagingFollow-up periodSignificantly higher riskCardiovascular risk factorsMagnetic resonance imagingMonths postablationArrhythmia recurrenceConsecutive patientsLA fibrosisAblation proceduresFibrosis progressionProcedural outcomesAblation lesionsRecurrence
2019
Left atrial functional and structural changes associated with ablation of atrial fibrillation - Cardiac magnetic resonance study
Csécs I, Yamaguchi T, Kheirkhahan M, Czimbalmos C, Fochler F, Kholmovski E, Morris A, Kaur G, Vago H, Merkely B, Chelu M, Marrouche N, Wilson B. Left atrial functional and structural changes associated with ablation of atrial fibrillation - Cardiac magnetic resonance study. International Journal Of Cardiology 2019, 305: 154-160. PMID: 31874788, DOI: 10.1016/j.ijcard.2019.12.010.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonance imagingCardiac magnetic resonance studyLA-LGEPredictors of recurrenceLate gadolinium enhancementLA volumeAtrial fibrillationPredictor of arrhythmia recurrenceSuccess of AF ablationAssessment of LA functionSelection of optimal treatment strategiesSuccess of atrial fibrillationOptimal treatment strategyBaseline functional parametersAssociated with ablationMagnetic resonance imagingArrhythmia recurrenceAF ablationAF patientsAtrial functionLA functionPost-ablationUnivariate analysisTreatment strategiesRecurrence