2022
An Explainable Machine Learning Approach Reveals Prognostic Significance of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy
Fahmy A, Csecs I, Arafati A, Assana S, Yankama T, Al-Otaibi T, Rodriguez J, Chen Y, Ngo L, Manning W, Kwong R, Nezafat R. An Explainable Machine Learning Approach Reveals Prognostic Significance of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy. JACC Cardiovascular Imaging 2022, 15: 766-779. PMID: 35033500, DOI: 10.1016/j.jcmg.2021.11.029.Peer-Reviewed Original ResearchConceptsNonischemic dilated cardiomyopathyBeth Israel Deaconess Medical CenterComposite endpointRight ventricular (RV) dysfunctionCardiovascular hospitalizationRisk prediction modelAdverse outcomesRisk markersMarker of adverse outcomeCardiac magnetic resonance markersRisk stratification of patientsRight ventricular dysfunctionRV ejection fractionMedical CenterFollow-up durationCardiac magnetic resonanceEnd-diastolic volumeStratification of patientsArea under the curveAll-cause deathHigh-risk thresholdVentricular dysfunctionEjection fractionNonischemic cardiomyopathyPrognostic significance
2021
Characterization of Aerosol Generation During Various Intensities of Exercise
Sajgalik P, Garzona-Navas A, Csécs I, Askew J, Lopez-Jimenez F, Niven A, Johnson B, Allison T. Characterization of Aerosol Generation During Various Intensities of Exercise. CHEST Journal 2021, 160: 1377-1387. PMID: 33957100, PMCID: PMC8473677, DOI: 10.1016/j.chest.2021.04.041.Peer-Reviewed Original ResearchConceptsHeart rate reserveRate reservePredicted heart rate reserveExercise testSafety of exercise testingPeak respiratory exchange ratioIntensity of exercisePeak heart rateRespiratory exchange ratioStages of exerciseExercise intensityExercise activitiesMaximal ventilationExchange ratioExerciseAerosol-generating proceduresActivity recoveryStatistically significant increaseSafety recommendationsHealthy volunteersFace of COVID-19Heart rateSignificant increaseRecommendationsCOVID-19Mitigation of Aerosols Generated During Exercise Testing With a Portable High-Efficiency Particulate Air Filter With Fume Hood
Garzona-Navas A, Sajgalik P, Csécs I, Askew J, Lopez-Jimenez F, Niven A, Johnson B, Allison T. Mitigation of Aerosols Generated During Exercise Testing With a Portable High-Efficiency Particulate Air Filter With Fume Hood. CHEST Journal 2021, 160: 1388-1396. PMID: 33895130, PMCID: PMC8463654, DOI: 10.1016/j.chest.2021.04.023.Peer-Reviewed Original ResearchConceptsExercise testing laboratoryPortable HEPA filterExercise testPortable high-efficiency particulate airAerosol concentrationsClearance timeConcentration of aerosolsExercise experienceStationary cyclingRisk of COVID-19 transmissionExerciseActivity recoveryHealthy volunteersAerosolQuiet breathingAerosol mitigationParticle counterAerosol clearanceClearance experimentsCOVID-19 pandemicCOVID-19 transmissionParticle concentrationLarger particlesCOVID-19
2020
Association Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy
Csecs I, Pashakhanloo F, Paskavitz A, Jang J, Al‐Otaibi T, Neisius U, Manning W, Nezafat R. Association Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy. Journal Of The American Heart Association 2020, 9: e016797. PMID: 33006296, PMCID: PMC7792406, DOI: 10.1161/jaha.120.016797.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementSeptal late gadolinium enhancementLV ejection fractionNonischemic cardiomyopathyExtent of fibrosisCardiovascular magnetic resonanceEjection fractionImpaired global circumferential strainImpaired LV ejection fractionLate gadolinium enhancement groupsDepressed LV ejection fractionClinical cardiovascular magnetic resonanceLeft ventricular (LVLGE-negative groupCircumferential strainGlobal radial strainGlobal longitudinal strainRadial strainGlobal circumferential strainLV deformation parametersGlobal LV functionAdverse cardiovascular outcomesLGE-positiveNonischemic fibrosisFibrosis burdenHigh-intensity endurance training is associated with left atrial fibrosis
Peritz D, Catino A, Csecs I, Kaur G, Kheirkhahan M, Loveless B, Wasmund S, Kholmovski E, Morris A, Marrouche N. High-intensity endurance training is associated with left atrial fibrosis. American Heart Journal 2020, 226: 206-213. PMID: 32615358, DOI: 10.1016/j.ahj.2020.05.015.Peer-Reviewed Original ResearchConceptsEndurance athletesMaster athletesHigh-intensity endurance trainingTrained endurance athletesNon-athlete controlsHealthy control subjectsLeft atrial fibrosisScreening colonoscopyEndurance trainingAthletic cohortHealthcare complexityAtrial fibrosisAthletesStudy participantsControl subjectsGeneral populationEnduranceQuantify fibrotic changesLeft atrial volumeIncreased atrial fibrosisLeft ventricular functionParticipantsAtrial volumeGadolinium enhancementFibrosis scoreMagnetic resonance imaging–guided cryoballoon ablation for left atrial substrate modification in patients with atrial fibrillation
Kirstein B, Morris A, Baher A, Csécs I, Kheirkhahan M, Kaur G, Kholmovski E, Marrouche N. Magnetic resonance imaging–guided cryoballoon ablation for left atrial substrate modification in patients with atrial fibrillation. Journal Of Cardiovascular Electrophysiology 2020, 31: 1587-1594. PMID: 32412119, DOI: 10.1111/jce.14551.Peer-Reviewed Original ResearchConceptsPulmonary vein isolationCryoballoon ablationLGE-MRIAtrial fibrillationFirst-time AF ablationGadolinium-enhanced magnetic resonance imagingTreatment of atrial fibrillationLA substrateLate gadolinium enhancement magnetic resonance imagingEnhanced magnetic resonance imagingEsophageal thermal injuryAtrial substrate modificationMagnetic resonance imagingVein isolationAF recurrenceAF ablationPulmonary veinsPeriprocedural dataLA scarRhythm monitoringSubstrate modificationResonance imagingThermal injuryCryoballoonPostablationHow are ECG parameters related to cardiac magnetic resonance images? Electrocardiographic predictors of left ventricular hypertrophy and myocardial fibrosis in hypertrophic cardiomyopathy
Dohy Z, Vereckei A, Horvath V, Czimbalmos C, Szabo L, Toth A, Suhai F, Csecs I, Becker D, Merkely B, Vago H. How are ECG parameters related to cardiac magnetic resonance images? Electrocardiographic predictors of left ventricular hypertrophy and myocardial fibrosis in hypertrophic cardiomyopathy. Annals Of Noninvasive Electrocardiology 2020, 25: e12763. PMID: 32329134, PMCID: PMC7507346, DOI: 10.1111/anec.12763.Peer-Reviewed Original ResearchConceptsRomhilt-Estes scoreLeft ventricular hypertrophyCardiac magnetic resonance imagingFragmented QRSSokolow-Lyon indexHypertrophic cardiomyopathyMyocardial fibrosisCornell indexMagnetic resonance imagingVentricular hypertrophyRepolarization abnormalitiesPredictor of myocardial fibrosisElectrocardiographic parametersPresence of fragmented QRSLeft ventricular ejection fractionDetectable left ventricular hypertrophyElectrocardiographic voltage criteriaResonance imagingVentricular ejection fractionHypertrophic cardiomyopathy patientsStructural myocardial changesDegree of myocardial fibrosisPathologic Q wavesAmount of fibrosisEjection fractionLeft atrial fibrosis progression detected by LGE‐MRI after ablation of atrial fibrillation
Kheirkhahan M, Baher A, Goldooz M, Kholmovski E, Morris A, Csecs I, Chelu M, Wilson B, Marrouche N. Left atrial fibrosis progression detected by LGE‐MRI after ablation of atrial fibrillation. Pacing And Clinical Electrophysiology 2020, 43: 402-411. PMID: 31867751, DOI: 10.1111/pace.13866.Peer-Reviewed Original ResearchConceptsAF recurrenceAF ablationLGE-MRIAtrial fibrillationLong-term procedural outcomesGadolinium-enhanced magnetic resonance imagingAssociated with significantly higher riskArrhythmia-free survivalAtrial arrhythmia recurrencePostablation AF recurrenceLate gadolinium enhancement magnetic resonance imagingEnhanced magnetic resonance imagingFollow-up periodSignificantly higher riskCardiovascular risk factorsMagnetic resonance imagingMonths postablationArrhythmia recurrenceConsecutive patientsLA fibrosisAblation proceduresFibrosis progressionProcedural outcomesAblation lesionsRecurrence
2019
Biventricular pacing during cardiac magnetic resonance imaging
Vago H, Czimbalmos C, Papp R, Szabo L, Toth A, Dohy Z, Csecs I, Suhai F, Kosztin A, Molnar L, Geller L, Merkely B. Biventricular pacing during cardiac magnetic resonance imaging. EP Europace 2019, 22: 117-124. PMID: 31713632, DOI: 10.1093/europace/euz289.Peer-Reviewed Original ResearchConceptsLV end-systolic volume indexLV ejection fractionLV end-diastolic volume indexNew York Heart AssociationCardiac magnetic resonance imagingCardiac magnetic resonanceRegional dyssynchronyBiventricular pacingAOO pacingMagnetic resonance imagingCMR parametersEffectiveness of resynchronization therapyLeft ventricular remodeling indexLeft ventricular (LV) functionCardiac magnetic resonance examinationEnd-diastolic volume indexEnd-systolic volume indexQuantification of LV functionVolume indexRemodeling indexConventional CMR parametersImprove responder rateResonance imagingOptimal medical therapyEffects of cardiac resynchronizationThe impact of sex, age and training on biventricular cardiac adaptation in healthy adult and adolescent athletes: Cardiac magnetic resonance imaging study
Csecs I, Czimbalmos C, Toth A, Dohy Z, Suhai I, Szabo L, Kovacs A, Lakatos B, Sydo N, Kheirkhahan M, Peritz D, Kiss O, Merkely B, Vago H. The impact of sex, age and training on biventricular cardiac adaptation in healthy adult and adolescent athletes: Cardiac magnetic resonance imaging study. European Journal Of Preventive Cardiology 2019, 27: 540-549. PMID: 31370686, DOI: 10.1177/2047487319866019.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAdolescentAdultAge FactorsAthletesCardiomegaly, Exercise-InducedFemaleHeart VentriclesHumansMagnetic Resonance Imaging, CineMalePhysical Conditioning, HumanPredictive Value of TestsSex FactorsVentricular Function, LeftVentricular Function, RightVentricular RemodelingYoung AdultConceptsEnd-diastolic volume indexVentricular mass indexTraining hoursBody surface areaTraining volumeEndurance sportsCardiac adaptationImpact of sexVentricular massMass indexMale sexRight ventricular end-diastolic volume indexHigher training volumeVentricular volumeLeft ventricular end-diastolic volume indexCardiac magnetic resonance parametersWeekly training hoursRight ventricular ejection fractionVolume indexLeft ventricular mass indexRight ventricular mass indexCardiac magnetic resonance imagingRight/left ventricular ratioVentricular ejection fractionEnd-systolic volumeThe effect of contrast agents on left ventricular parameters calculated by a threshold-based software module: does it truly matter?
Szűcs A, Kiss A, Suhai F, Tóth A, Gregor Z, Horváth M, Czimbalmos C, Csécs I, Dohy Z, Szabó L, Merkely B, Vágó H. The effect of contrast agents on left ventricular parameters calculated by a threshold-based software module: does it truly matter? The International Journal Of Cardiovascular Imaging 2019, 35: 1683-1689. PMID: 31037474, PMCID: PMC6700040, DOI: 10.1007/s10554-019-01587-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomechanical PhenomenaCase-Control StudiesContrast MediaFemaleHeart VentriclesHumansImage Interpretation, Computer-AssistedIsolated Noncompaction of the Ventricular MyocardiumMagnetic Resonance Imaging, CineMaleMeglumineMiddle AgedOrganometallic CompoundsPredictive Value of TestsProspective StudiesReproducibility of ResultsSoftwareStroke VolumeVentricular Function, LeftYoung AdultConceptsSteady-state free precessionGadobenate dimeglumineCine imagesLeft ventricular parametersAdministration of contrast agentContrast agentsLeft ventricular volumeBlood-myocardium contrastEffects of contrast agentsNoncompaction cardiomyopathyVentricular parametersTrabecular musclesVentricular volumeCardiac parametersPre-CASShort axisTime-saving techniqueGadobutrolTrabecular massH groupFree precessionTrabecularEffect of CALVmassCardiomyopathyThe demanding grey zone: Sport indices by cardiac magnetic resonance imaging differentiate hypertrophic cardiomyopathy from athlete’s heart
Czimbalmos C, Csecs I, Toth A, Kiss O, Suhai F, Sydo N, Dohy Z, Apor A, Merkely B, Vago H. The demanding grey zone: Sport indices by cardiac magnetic resonance imaging differentiate hypertrophic cardiomyopathy from athlete’s heart. PLOS ONE 2019, 14: e0211624. PMID: 30763323, PMCID: PMC6375568, DOI: 10.1371/journal.pone.0211624.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonancePathological left ventricular hypertrophyHypertrophic cardiomyopathyVentricular hypertrophySport indexCardiac magnetic resonance imagingEnd-diastolic volume ratioHypertrophic cardiomyopathy patientsLeft ventricular massEnd-diastolic wall thicknessCut-off valueGray zoneMagnetic resonance imagingHCM patientsCardiomyopathy patientsTrained athletesVentricular massPhysiological hypertrophyDiagnostic accuracyAthlete's heartCardiomyopathyHypertrophyMale subgroupResonance imagingEDWT
2018
Cardiac magnetic resonance based deformation imaging: role of feature tracking in athletes with suspected arrhythmogenic right ventricular cardiomyopathy
Czimbalmos C, Csecs I, Dohy Z, Toth A, Suhai F, Müssigbrodt A, Kiss O, Geller L, Merkely B, Vago H. Cardiac magnetic resonance based deformation imaging: role of feature tracking in athletes with suspected arrhythmogenic right ventricular cardiomyopathy. The International Journal Of Cardiovascular Imaging 2018, 35: 529-538. PMID: 30382474, PMCID: PMC6453871, DOI: 10.1007/s10554-018-1478-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultArrhythmogenic Right Ventricular DysplasiaAthletesCardiomegaly, Exercise-InducedCase-Control StudiesDiagnosis, DifferentialFemaleHeart VentriclesHumansImage Interpretation, Computer-AssistedMagnetic Resonance Imaging, CineMaleMyocardial ContractionPredictive Value of TestsReproducibility of ResultsStroke VolumeVentricular Function, LeftVentricular Function, RightVentricular RemodelingConceptsArrhythmogenic right ventricular cardiomyopathyRV ejection fractionCardiac magnetic resonanceTask Force criteriaRV free wallRight ventricular cardiomyopathyCut-off valueAthlete's heartVentricular cardiomyopathyBalanced steady-state free precession cine imagesRight ventricular (RV) remodelingSuspected arrhythmogenic right ventricular cardiomyopathyDiagnosis of arrhythmogenic right ventricular cardiomyopathySteady-state free precession cine imagesFree wallHealthy athletesRV strain analysisRight ventricular volumesRV dilatationEjection fractionCine imagesVentricular volumeRegional strain analysisTrained athletesMagnetic resonanceLeft and right ventricular parameters corrected with threshold-based quantification method in a normal cohort analyzed by three independent observers with various training-degree
Csecs I, Czimbalmos C, Suhai F, Mikle R, Mirzahosseini A, Dohy Z, Szűcs A, Kiss A, Simor T, Tóth A, Merkely B, Vágó H. Left and right ventricular parameters corrected with threshold-based quantification method in a normal cohort analyzed by three independent observers with various training-degree. The International Journal Of Cardiovascular Imaging 2018, 34: 1127-1133. PMID: 29492774, DOI: 10.1007/s10554-018-1322-4.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonancePapillary musclesInterobserver agreementIndependent observersShort-axis cine imagesCardiac magnetic resonance scansRight ventricular parametersRV ejection fractionRight ventricular functionInvestigate interobserver variabilityGlobal intraclass correlation coefficientAssess LVIntraclass correlation coefficientRV parametersEjection fractionVentricular parametersVentricular functionHealthy volunteersCine imagesLV parametersEnd-diastolicInterobserver variabilityMeasure LVEnd-systoleTB method
2017
Uncommon presentation of a rare tumour - incidental finding in an asymptomatic patient: case report and comprehensive review of the literature on intrapericardial solitary fibrous tumours
Czimbalmos C, Csecs I, Polos M, Bartha E, Szucs N, Toth A, Maurovich-Horvat P, Becker D, Sapi Z, Szabolcs Z, Merkely B, Vago H. Uncommon presentation of a rare tumour - incidental finding in an asymptomatic patient: case report and comprehensive review of the literature on intrapericardial solitary fibrous tumours. BMC Cancer 2017, 17: 612. PMID: 28865431, PMCID: PMC5581469, DOI: 10.1186/s12885-017-3574-0.Peer-Reviewed Original ResearchConceptsSolitary fibrous tumorFibrous tumorAsymptomatic patientsPulmonary trunkIncidental findingBackgroundA solitary fibrous tumourRegular MRI follow-upSpindle cell mesenchymal tumorsScreening chest X-rayCoronary computed tomography angiographyAsymptomatic female patientLate gadolinium enhancement imagingMRI follow-upCardiac magnetic resonanceEnlarged cardiac silhouetteLong-term followComputed tomography angiographyFirst-pass perfusionGadolinium-enhanced imagesChest X-rayInversion recovery imagesIntermediate signal intensityProton density-weighted imagesPatternless patternComplete resection