2022
The role of cardiac magnetic resonance-based feature-tracking strain analysis in the differential diagnosis and prognostic assessment of patients with left ventricular hypertrophy
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. The role of cardiac magnetic resonance-based feature-tracking strain analysis in the differential diagnosis and prognostic assessment of patients with left ventricular hypertrophy. European Heart Journal 2022, 43: ehac544.272. DOI: 10.1093/eurheartj/ehac544.272.Peer-Reviewed Original ResearchFeature-tracking strain analysisCardiac magnetic resonanceLeft ventricular hypertrophyLV hypertrophyMyocardial diseaseHypertrophic cardiomyopathyEndomyocardial fibrosisBasal LSCardiac amyloidosisCA patientsVentricular hypertrophyGlobal dyssynchronyDifferential diagnosisLeft ventricular (LV) hypertrophyPatient populationCardiac magnetic resonance examinationLV stroke volume indexFabry diseasePrognostic assessment of patientsSignificant independent predictors of mortalityIndependent predictor of mortalityEndomyocardial fibrosis patientsLV strain parametersLV) hypertrophyLV strain analysisPotential clinical relevance of cardiac magnetic resonance to diagnose cardiac light chain amyloidosis
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. Potential clinical relevance of cardiac magnetic resonance to diagnose cardiac light chain amyloidosis. PLOS ONE 2022, 17: e0269807. PMID: 35696411, PMCID: PMC9191721, DOI: 10.1371/journal.pone.0269807.Peer-Reviewed Original ResearchConceptsCardiac AL amyloidosisCardiac magnetic resonanceLate gadolinium enhancementAL amyloidosisOptimal diagnostic performanceHypertrophic cardiomyopathyDegree of left ventricular (LV) hypertrophyReduced global LV longitudinal strainDiagnostic performanceLeft ventricular (LV) hypertrophyPattern of late gadolinium enhancementGlobal LV longitudinal strainSubendocardial late gadolinium enhancementCardiac magnetic resonance examinationCardiac magnetic resonance parametersCardiac light-chain amyloidosisDifferential diagnosis of cardiomyopathyLV strain parametersCardiac transthyretin amyloidosisLV) hypertrophyLV longitudinal strainDiagnosis of cardiomyopathyLight chain amyloidosisCardiac light chainsPotential clinical relevance
2021
The role of feature-tracking strain analysis in the differentiation of cardiac amyloidosis from hypertrophic cardiomyopathy
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. The role of feature-tracking strain analysis in the differentiation of cardiac amyloidosis from hypertrophic cardiomyopathy. European Heart Journal 2021, 42: ehab724.0240. DOI: 10.1093/eurheartj/ehab724.0240.Peer-Reviewed Original ResearchCardiac involvement of amyloidosisLeft ventricular ejection fractionLate gadolinium enhancementCardiac magnetic resonanceAmount of late gadolinium enhancementHypertrophic cardiomyopathy patientsFeature-tracking strain analysisCA patientsHypertrophic cardiomyopathyBasal LSDiagnostic accuracyPattern of late gadolinium enhancementCardiac magnetic resonance diagnosisCardiac magnetic resonance examinationSignificant independent predictors of mortalityCox proportional hazards regression analysisIndependent predictor of mortalityLV strain parametersRegional strain valuesYears of follow-upProportional hazards regression analysisVentricular ejection fractionOptimal cutoff valueLog-rank testDiagnosis of CAMachine learning phenotyping of scarred myocardium from cine in hypertrophic cardiomyopathy
Mancio J, Pashakhanloo F, El-Rewaidy H, Jang J, Joshi G, Csecs I, Ngo L, Rowin E, Manning W, Maron M, Nezafat R. Machine learning phenotyping of scarred myocardium from cine in hypertrophic cardiomyopathy. European Heart Journal - Cardiovascular Imaging 2021, 23: 532-542. PMID: 33779725, PMCID: PMC9125682, DOI: 10.1093/ehjci/jeab056.Peer-Reviewed Original Research
2020
Differentiation between physiological sport adaptation and hypertrophic cardiomyopathy in highly trained athletes using cardiac magnetic resonance
Czimbalmos C, Nardocci C, Deetjen E, Szabo L, Dohy Z, Toth A, Suhai F, Csecs I, Horvath V, Kiss O, Sydo N, Merkely B, Vago H. Differentiation between physiological sport adaptation and hypertrophic cardiomyopathy in highly trained athletes using cardiac magnetic resonance. European Heart Journal 2020, 41: ehaa946.3119. DOI: 10.1093/ehjci/ehaa946.3119.Peer-Reviewed Original ResearchCardiac magnetic resonance parametersCardiac magnetic resonanceLate gadolinium enhancementDiagnosis of hypertrophic cardiomyopathyHypertrophic cardiomyopathyCut-off valueHCM patientsHealthy athletesPresence of late gadolinium enhancementOptimal cut-off valueCardiac magnetic resonance characteristicsConventional CMR parametersReceiver operating curve analysisDiagnose HCMEnd-diastolic wall thicknessPathological left ventricular hypertrophyOperating curve analysisGlobal longitudinalGadolinium enhancementLV functionVentricular hypertrophyCMR parametersClinical conundrumHypertrophy patternCurve analysisHow are ECG parameters related to cardiac magnetic resonance images? Electrocardiographic predictors of left ventricular hypertrophy and myocardial fibrosis in hypertrophic cardiomyopathy
Dohy Z, Vereckei A, Horvath V, Czimbalmos C, Szabo L, Toth A, Suhai F, Csecs I, Becker D, Merkely B, Vago H. How are ECG parameters related to cardiac magnetic resonance images? Electrocardiographic predictors of left ventricular hypertrophy and myocardial fibrosis in hypertrophic cardiomyopathy. Annals Of Noninvasive Electrocardiology 2020, 25: e12763. PMID: 32329134, PMCID: PMC7507346, DOI: 10.1111/anec.12763.Peer-Reviewed Original ResearchConceptsRomhilt-Estes scoreLeft ventricular hypertrophyCardiac magnetic resonance imagingFragmented QRSSokolow-Lyon indexHypertrophic cardiomyopathyMyocardial fibrosisCornell indexMagnetic resonance imagingVentricular hypertrophyRepolarization abnormalitiesPredictor of myocardial fibrosisElectrocardiographic parametersPresence of fragmented QRSLeft ventricular ejection fractionDetectable left ventricular hypertrophyElectrocardiographic voltage criteriaResonance imagingVentricular ejection fractionHypertrophic cardiomyopathy patientsStructural myocardial changesDegree of myocardial fibrosisPathologic Q wavesAmount of fibrosisEjection fractionP363 Cardiac magnetic resonance characteristics of patients in the grey zone of hypertrophy
Czimbalmos C, Csecs I, Horvath V, Deetjen E, Nardocci C, Dohy Z, Szabo L, Suhai F, Toth A, Sydo N, Kiss O, Merkely B, Vago H. P363 Cardiac magnetic resonance characteristics of patients in the grey zone of hypertrophy. European Heart Journal - Cardiovascular Imaging 2020, 21 DOI: 10.1093/ehjci/jez319.212.Peer-Reviewed Original ResearchLate gadolinium enhancementCardiac magnetic resonancePresence of late gadolinium enhancementHCM patientsHypertrophic cardiomyopathyInter-observer analysisHealthy athletesGadolinium enhancementCardiac magnetic resonance characteristicsStandard deviation of timeConventional CMR parametersMale HCM patientsEnd-diastolic wall thicknessGlobal strain valuesCut-off valueCharacteristics of patientsGray zoneGlobal longitudinalIntraventricular dyssynchronyHypertrophic segmentsCMR parametersDifferential diagnosisDelayed contrastHCM groupPatient group
2019
P4429Cardiac magnetic resonance characteristics of professional athletes and hypertrophic cardiomyopathy patients in the grey zone of hypertrophy
Czimbalmos C, Csecs I, Dohy Z, Toth A, Suhai F, Szabo L, Horvath V, Sydo N, Kiss O, Becker D, Merkely B, Vago H. P4429Cardiac magnetic resonance characteristics of professional athletes and hypertrophic cardiomyopathy patients in the grey zone of hypertrophy. European Heart Journal 2019, 40: ehz745.0831. DOI: 10.1093/eurheartj/ehz745.0831.Peer-Reviewed Original ResearchMale HCM patientsHCM patientsHypertrophic cardiomyopathy patientsHypertrophic cardiomyopathyHealthy athletesEjection fractionLeft ventricular (LV) ejection fractionLV) ejection fractionConventional CMR parametersCardiac magnetic resonanceEnd-diastolic wall thicknessLV hypertrophyCardiomyopathy patientsNo significant differenceCMR parametersGray zoneHCM groupEnd-diastolicPhysiological hypertrophyPatient groupAthlete's heartEnd-systolePatientsHypertrophyStroke volume4251Results from the Hungarian Cardiac Magnetic Resonance Registry of Structural Heart Disease and Aborted Sudden Cardiac Death in Athletes
Vago H, Szabo L, Czimbalmos C, Dohy Z, Csecs I, Toth A, Suhai I, Simor T, Becker D, Merkely B. 4251Results from the Hungarian Cardiac Magnetic Resonance Registry of Structural Heart Disease and Aborted Sudden Cardiac Death in Athletes. European Heart Journal 2019, 40: ehz745.0134. DOI: 10.1093/eurheartj/ehz745.0134.Peer-Reviewed Original ResearchArrhythmogenic right ventricular cardiomyopathyAborted sudden cardiac deathCardiac magnetic resonanceLate gadolinium enhancementSudden cardiac deathStructural heart diseaseStructural myocardial diseaseTako-tsubo cardiomyopathyHypertrophic cardiomyopathyCardiac deathLGE patternHeart diseaseDilated cardiomyopathyMyocardial diseaseSubendocardial late gadolinium enhancementEtiology of sudden cardiac deathCardiac magnetic resonance scansStructural myocardial abnormalitiesCoronary artery abnormalitiesRight ventricular cardiomyopathySustained ventricular tachycardiaWall motion abnormalitiesCases further investigationsAspecific patternAcute myocarditisThe demanding grey zone: Sport indices by cardiac magnetic resonance imaging differentiate hypertrophic cardiomyopathy from athlete’s heart
Czimbalmos C, Csecs I, Toth A, Kiss O, Suhai F, Sydo N, Dohy Z, Apor A, Merkely B, Vago H. The demanding grey zone: Sport indices by cardiac magnetic resonance imaging differentiate hypertrophic cardiomyopathy from athlete’s heart. PLOS ONE 2019, 14: e0211624. PMID: 30763323, PMCID: PMC6375568, DOI: 10.1371/journal.pone.0211624.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonancePathological left ventricular hypertrophyHypertrophic cardiomyopathyVentricular hypertrophySport indexCardiac magnetic resonance imagingEnd-diastolic volume ratioHypertrophic cardiomyopathy patientsLeft ventricular massEnd-diastolic wall thicknessCut-off valueGray zoneMagnetic resonance imagingHCM patientsCardiomyopathy patientsTrained athletesVentricular massPhysiological hypertrophyDiagnostic accuracyAthlete's heartCardiomyopathyHypertrophyMale subgroupResonance imagingEDWT