2022
The role of cardiac magnetic resonance-based feature-tracking strain analysis in the differential diagnosis and prognostic assessment of patients with left ventricular hypertrophy
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. The role of cardiac magnetic resonance-based feature-tracking strain analysis in the differential diagnosis and prognostic assessment of patients with left ventricular hypertrophy. European Heart Journal 2022, 43: ehac544.272. DOI: 10.1093/eurheartj/ehac544.272.Peer-Reviewed Original ResearchFeature-tracking strain analysisCardiac magnetic resonanceLeft ventricular hypertrophyLV hypertrophyMyocardial diseaseHypertrophic cardiomyopathyEndomyocardial fibrosisBasal LSCardiac amyloidosisCA patientsVentricular hypertrophyGlobal dyssynchronyDifferential diagnosisLeft ventricular (LV) hypertrophyPatient populationCardiac magnetic resonance examinationLV stroke volume indexFabry diseasePrognostic assessment of patientsSignificant independent predictors of mortalityIndependent predictor of mortalityEndomyocardial fibrosis patientsLV strain parametersLV) hypertrophyLV strain analysisPotential clinical relevance of cardiac magnetic resonance to diagnose cardiac light chain amyloidosis
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. Potential clinical relevance of cardiac magnetic resonance to diagnose cardiac light chain amyloidosis. PLOS ONE 2022, 17: e0269807. PMID: 35696411, PMCID: PMC9191721, DOI: 10.1371/journal.pone.0269807.Peer-Reviewed Original ResearchConceptsCardiac AL amyloidosisCardiac magnetic resonanceLate gadolinium enhancementAL amyloidosisOptimal diagnostic performanceHypertrophic cardiomyopathyDegree of left ventricular (LV) hypertrophyReduced global LV longitudinal strainDiagnostic performanceLeft ventricular (LV) hypertrophyPattern of late gadolinium enhancementGlobal LV longitudinal strainSubendocardial late gadolinium enhancementCardiac magnetic resonance examinationCardiac magnetic resonance parametersCardiac light-chain amyloidosisDifferential diagnosis of cardiomyopathyLV strain parametersCardiac transthyretin amyloidosisLV) hypertrophyLV longitudinal strainDiagnosis of cardiomyopathyLight chain amyloidosisCardiac light chainsPotential clinical relevanceAn Explainable Machine Learning Approach Reveals Prognostic Significance of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy
Fahmy A, Csecs I, Arafati A, Assana S, Yankama T, Al-Otaibi T, Rodriguez J, Chen Y, Ngo L, Manning W, Kwong R, Nezafat R. An Explainable Machine Learning Approach Reveals Prognostic Significance of Right Ventricular Dysfunction in Nonischemic Cardiomyopathy. JACC Cardiovascular Imaging 2022, 15: 766-779. PMID: 35033500, DOI: 10.1016/j.jcmg.2021.11.029.Peer-Reviewed Original ResearchConceptsNonischemic dilated cardiomyopathyBeth Israel Deaconess Medical CenterComposite endpointRight ventricular (RV) dysfunctionCardiovascular hospitalizationRisk prediction modelAdverse outcomesRisk markersMarker of adverse outcomeCardiac magnetic resonance markersRisk stratification of patientsRight ventricular dysfunctionRV ejection fractionMedical CenterFollow-up durationCardiac magnetic resonanceEnd-diastolic volumeStratification of patientsArea under the curveAll-cause deathHigh-risk thresholdVentricular dysfunctionEjection fractionNonischemic cardiomyopathyPrognostic significance
2021
The role of feature-tracking strain analysis in the differentiation of cardiac amyloidosis from hypertrophic cardiomyopathy
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. The role of feature-tracking strain analysis in the differentiation of cardiac amyloidosis from hypertrophic cardiomyopathy. European Heart Journal 2021, 42: ehab724.0240. DOI: 10.1093/eurheartj/ehab724.0240.Peer-Reviewed Original ResearchCardiac involvement of amyloidosisLeft ventricular ejection fractionLate gadolinium enhancementCardiac magnetic resonanceAmount of late gadolinium enhancementHypertrophic cardiomyopathy patientsFeature-tracking strain analysisCA patientsHypertrophic cardiomyopathyBasal LSDiagnostic accuracyPattern of late gadolinium enhancementCardiac magnetic resonance diagnosisCardiac magnetic resonance examinationSignificant independent predictors of mortalityCox proportional hazards regression analysisIndependent predictor of mortalityLV strain parametersRegional strain valuesYears of follow-upProportional hazards regression analysisVentricular ejection fractionOptimal cutoff valueLog-rank testDiagnosis of CASensitivity of Myocardial Radiomic Features to Imaging Parameters in Cardiac MR Imaging
Jang J, El‐Rewaidy H, Ngo L, Mancio J, Csecs I, Rodriguez J, Pierce P, Goddu B, Neisius U, Manning W, Nezafat R. Sensitivity of Myocardial Radiomic Features to Imaging Parameters in Cardiac MR Imaging. Journal Of Magnetic Resonance Imaging 2021, 54: 787-794. PMID: 33650227, PMCID: PMC9190024, DOI: 10.1002/jmri.27581.Peer-Reviewed Original ResearchConceptsRadiomic featuresIn-plane spatial resolutionImaging parametersSpatial resolutionBalanced steady-state free precessionCardiac magnetic resonanceIn-plane resolutionStandardized mean differenceSteady-state free precessionParallel imaging techniquesFlip angleCardiac MRCardiac MR imagesFree precessionMean differenceSlice thicknessMR imagingMagnetic resonanceCalculated valuesMyocardial contoursSequence parametersImaging techniquesWavelet filters
2020
Cardiac changes after cardiac resynchronization therapy assessed using cardiac magnetic resonance imaging during biventricular pacing
Czimbalmos C, Papp R, Szabo L, Toth A, Csecs I, Suhai F, Molnar L, Kosztin A, Geller L, Merkely B, Vago H. Cardiac changes after cardiac resynchronization therapy assessed using cardiac magnetic resonance imaging during biventricular pacing. European Heart Journal 2020, 41: ehaa946.0808. DOI: 10.1093/ehjci/ehaa946.0808.Peer-Reviewed Original ResearchCardiac magnetic resonanceCardiac resynchronization therapyCardiac magnetic resonance imagingBiventricular pacingRegional dyssynchronyResynchronization therapyAOO pacingCMR parametersEffectiveness of resynchronization therapyCardiac magnetic resonance examinationEffects of cardiac resynchronization therapyRight ventricular ejection fractionEnd-systolic volume indexQuantification of LV functionRemodeling indexConventional CMR parametersImprove responder rateLV remodeling indexII-III patientsOptimal medical therapyRight ventricular volumesVentricular ejection fractionEnd-diastolic indexEffects of cardiac resynchronizationRelative wall thicknessDifferentiation between physiological sport adaptation and hypertrophic cardiomyopathy in highly trained athletes using cardiac magnetic resonance
Czimbalmos C, Nardocci C, Deetjen E, Szabo L, Dohy Z, Toth A, Suhai F, Csecs I, Horvath V, Kiss O, Sydo N, Merkely B, Vago H. Differentiation between physiological sport adaptation and hypertrophic cardiomyopathy in highly trained athletes using cardiac magnetic resonance. European Heart Journal 2020, 41: ehaa946.3119. DOI: 10.1093/ehjci/ehaa946.3119.Peer-Reviewed Original ResearchCardiac magnetic resonance parametersCardiac magnetic resonanceLate gadolinium enhancementDiagnosis of hypertrophic cardiomyopathyHypertrophic cardiomyopathyCut-off valueHCM patientsHealthy athletesPresence of late gadolinium enhancementOptimal cut-off valueCardiac magnetic resonance characteristicsConventional CMR parametersReceiver operating curve analysisDiagnose HCMEnd-diastolic wall thicknessPathological left ventricular hypertrophyOperating curve analysisGlobal longitudinalGadolinium enhancementLV functionVentricular hypertrophyCMR parametersClinical conundrumHypertrophy patternCurve analysisP363 Cardiac magnetic resonance characteristics of patients in the grey zone of hypertrophy
Czimbalmos C, Csecs I, Horvath V, Deetjen E, Nardocci C, Dohy Z, Szabo L, Suhai F, Toth A, Sydo N, Kiss O, Merkely B, Vago H. P363 Cardiac magnetic resonance characteristics of patients in the grey zone of hypertrophy. European Heart Journal - Cardiovascular Imaging 2020, 21 DOI: 10.1093/ehjci/jez319.212.Peer-Reviewed Original ResearchLate gadolinium enhancementCardiac magnetic resonancePresence of late gadolinium enhancementHCM patientsHypertrophic cardiomyopathyInter-observer analysisHealthy athletesGadolinium enhancementCardiac magnetic resonance characteristicsStandard deviation of timeConventional CMR parametersMale HCM patientsEnd-diastolic wall thicknessGlobal strain valuesCut-off valueCharacteristics of patientsGray zoneGlobal longitudinalIntraventricular dyssynchronyHypertrophic segmentsCMR parametersDifferential diagnosisDelayed contrastHCM groupPatient group
2019
Biventricular pacing during cardiac magnetic resonance imaging
Vago H, Czimbalmos C, Papp R, Szabo L, Toth A, Dohy Z, Csecs I, Suhai F, Kosztin A, Molnar L, Geller L, Merkely B. Biventricular pacing during cardiac magnetic resonance imaging. EP Europace 2019, 22: 117-124. PMID: 31713632, DOI: 10.1093/europace/euz289.Peer-Reviewed Original ResearchConceptsLV end-systolic volume indexLV ejection fractionLV end-diastolic volume indexNew York Heart AssociationCardiac magnetic resonance imagingCardiac magnetic resonanceRegional dyssynchronyBiventricular pacingAOO pacingMagnetic resonance imagingCMR parametersEffectiveness of resynchronization therapyLeft ventricular remodeling indexLeft ventricular (LV) functionCardiac magnetic resonance examinationEnd-diastolic volume indexEnd-systolic volume indexQuantification of LV functionVolume indexRemodeling indexConventional CMR parametersImprove responder rateResonance imagingOptimal medical therapyEffects of cardiac resynchronizationP1528The added value of cardiac magnetic resonance to the diagnosis of patients after aborted sudden cardiac death
Szabo L, Czimbalmos C, Dohy Z, Csecs I, Toth A, Suhai F, Becker D, Geller L, Merkely B, Vago H. P1528The added value of cardiac magnetic resonance to the diagnosis of patients after aborted sudden cardiac death. European Heart Journal 2019, 40: ehz748.0290. DOI: 10.1093/eurheartj/ehz748.0290.Peer-Reviewed Original ResearchCardiac magnetic resonance imagingNormal coronary angiographyLate gadolinium enhancementAborted sudden cardiac deathSudden cardiac deathCardiac magnetic resonance imaging examinationRight ventricular parametersCardiac magnetic resonanceCardiac deathVentricular parametersDiagnostic value of cardiac magnetic resonance imagingPrimary cause of sudden cardiac deathPresence of late gadolinium enhancementDiagnostic valueStructural myocardial abnormalitiesStructural myocardial alterationsCause of sudden cardiac deathLate gadolinium enhancement imagingTask Force criteriaDiagnosis of patientsCoronary artery diseaseStructural alterationsMagnetic resonance imagingConsecutive patientsLV dilatationP310Differentiation between arrhythmogenic right ventricular cardiomyopathy and athlete's heart using cardiac magnetic resonance based derived parameters and strain analysis
Czimbalmos C, Csecs I, Dohy Z, Toth A, Suhai F, Szabo L, Kiss O, Sydo N, Kovacs A, Lakatos B, Merkely B, Vago H. P310Differentiation between arrhythmogenic right ventricular cardiomyopathy and athlete's heart using cardiac magnetic resonance based derived parameters and strain analysis. European Heart Journal 2019, 40: ehz747.0145. DOI: 10.1093/eurheartj/ehz747.0145.Peer-Reviewed Original ResearchArrhythmogenic right ventricular cardiomyopathyArrhythmogenic right ventricular cardiomyopathy patientsTask Force criteriaRight ventricular cardiomyopathyCMR parametersARVC patientsEjection fractionVentricular cardiomyopathyDiagnostic accuracyRevised task force criteriaAthlete's heartForce criteriaDiagnosing ARVCRegional strain valuesRV global strainRV strain parametersEnd-diastolic volume ratioRight ventricular end-systolicGlobal circumferential strainRV strain rateCardiac magnetic resonanceStroke volume indexVentricular end-systolicT-wave inversionCut-off valueP4429Cardiac magnetic resonance characteristics of professional athletes and hypertrophic cardiomyopathy patients in the grey zone of hypertrophy
Czimbalmos C, Csecs I, Dohy Z, Toth A, Suhai F, Szabo L, Horvath V, Sydo N, Kiss O, Becker D, Merkely B, Vago H. P4429Cardiac magnetic resonance characteristics of professional athletes and hypertrophic cardiomyopathy patients in the grey zone of hypertrophy. European Heart Journal 2019, 40: ehz745.0831. DOI: 10.1093/eurheartj/ehz745.0831.Peer-Reviewed Original ResearchMale HCM patientsHCM patientsHypertrophic cardiomyopathy patientsHypertrophic cardiomyopathyHealthy athletesEjection fractionLeft ventricular (LV) ejection fractionLV) ejection fractionConventional CMR parametersCardiac magnetic resonanceEnd-diastolic wall thicknessLV hypertrophyCardiomyopathy patientsNo significant differenceCMR parametersGray zoneHCM groupEnd-diastolicPhysiological hypertrophyPatient groupAthlete's heartEnd-systolePatientsHypertrophyStroke volume4251Results from the Hungarian Cardiac Magnetic Resonance Registry of Structural Heart Disease and Aborted Sudden Cardiac Death in Athletes
Vago H, Szabo L, Czimbalmos C, Dohy Z, Csecs I, Toth A, Suhai I, Simor T, Becker D, Merkely B. 4251Results from the Hungarian Cardiac Magnetic Resonance Registry of Structural Heart Disease and Aborted Sudden Cardiac Death in Athletes. European Heart Journal 2019, 40: ehz745.0134. DOI: 10.1093/eurheartj/ehz745.0134.Peer-Reviewed Original ResearchArrhythmogenic right ventricular cardiomyopathyAborted sudden cardiac deathCardiac magnetic resonanceLate gadolinium enhancementSudden cardiac deathStructural heart diseaseStructural myocardial diseaseTako-tsubo cardiomyopathyHypertrophic cardiomyopathyCardiac deathLGE patternHeart diseaseDilated cardiomyopathyMyocardial diseaseSubendocardial late gadolinium enhancementEtiology of sudden cardiac deathCardiac magnetic resonance scansStructural myocardial abnormalitiesCoronary artery abnormalitiesRight ventricular cardiomyopathySustained ventricular tachycardiaWall motion abnormalitiesCases further investigationsAspecific patternAcute myocarditisThe demanding grey zone: Sport indices by cardiac magnetic resonance imaging differentiate hypertrophic cardiomyopathy from athlete’s heart
Czimbalmos C, Csecs I, Toth A, Kiss O, Suhai F, Sydo N, Dohy Z, Apor A, Merkely B, Vago H. The demanding grey zone: Sport indices by cardiac magnetic resonance imaging differentiate hypertrophic cardiomyopathy from athlete’s heart. PLOS ONE 2019, 14: e0211624. PMID: 30763323, PMCID: PMC6375568, DOI: 10.1371/journal.pone.0211624.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonancePathological left ventricular hypertrophyHypertrophic cardiomyopathyVentricular hypertrophySport indexCardiac magnetic resonance imagingEnd-diastolic volume ratioHypertrophic cardiomyopathy patientsLeft ventricular massEnd-diastolic wall thicknessCut-off valueGray zoneMagnetic resonance imagingHCM patientsCardiomyopathy patientsTrained athletesVentricular massPhysiological hypertrophyDiagnostic accuracyAthlete's heartCardiomyopathyHypertrophyMale subgroupResonance imagingEDWT
2018
Cardiac magnetic resonance based deformation imaging: role of feature tracking in athletes with suspected arrhythmogenic right ventricular cardiomyopathy
Czimbalmos C, Csecs I, Dohy Z, Toth A, Suhai F, Müssigbrodt A, Kiss O, Geller L, Merkely B, Vago H. Cardiac magnetic resonance based deformation imaging: role of feature tracking in athletes with suspected arrhythmogenic right ventricular cardiomyopathy. The International Journal Of Cardiovascular Imaging 2018, 35: 529-538. PMID: 30382474, PMCID: PMC6453871, DOI: 10.1007/s10554-018-1478-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultArrhythmogenic Right Ventricular DysplasiaAthletesCardiomegaly, Exercise-InducedCase-Control StudiesDiagnosis, DifferentialFemaleHeart VentriclesHumansImage Interpretation, Computer-AssistedMagnetic Resonance Imaging, CineMaleMyocardial ContractionPredictive Value of TestsReproducibility of ResultsStroke VolumeVentricular Function, LeftVentricular Function, RightVentricular RemodelingConceptsArrhythmogenic right ventricular cardiomyopathyRV ejection fractionCardiac magnetic resonanceTask Force criteriaRV free wallRight ventricular cardiomyopathyCut-off valueAthlete's heartVentricular cardiomyopathyBalanced steady-state free precession cine imagesRight ventricular (RV) remodelingSuspected arrhythmogenic right ventricular cardiomyopathyDiagnosis of arrhythmogenic right ventricular cardiomyopathySteady-state free precession cine imagesFree wallHealthy athletesRV strain analysisRight ventricular volumesRV dilatationEjection fractionCine imagesVentricular volumeRegional strain analysisTrained athletesMagnetic resonanceLeft and right ventricular parameters corrected with threshold-based quantification method in a normal cohort analyzed by three independent observers with various training-degree
Csecs I, Czimbalmos C, Suhai F, Mikle R, Mirzahosseini A, Dohy Z, Szűcs A, Kiss A, Simor T, Tóth A, Merkely B, Vágó H. Left and right ventricular parameters corrected with threshold-based quantification method in a normal cohort analyzed by three independent observers with various training-degree. The International Journal Of Cardiovascular Imaging 2018, 34: 1127-1133. PMID: 29492774, DOI: 10.1007/s10554-018-1322-4.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonancePapillary musclesInterobserver agreementIndependent observersShort-axis cine imagesCardiac magnetic resonance scansRight ventricular parametersRV ejection fractionRight ventricular functionInvestigate interobserver variabilityGlobal intraclass correlation coefficientAssess LVIntraclass correlation coefficientRV parametersEjection fractionVentricular parametersVentricular functionHealthy volunteersCine imagesLV parametersEnd-diastolicInterobserver variabilityMeasure LVEnd-systoleTB method
2017
Uncommon presentation of a rare tumour - incidental finding in an asymptomatic patient: case report and comprehensive review of the literature on intrapericardial solitary fibrous tumours
Czimbalmos C, Csecs I, Polos M, Bartha E, Szucs N, Toth A, Maurovich-Horvat P, Becker D, Sapi Z, Szabolcs Z, Merkely B, Vago H. Uncommon presentation of a rare tumour - incidental finding in an asymptomatic patient: case report and comprehensive review of the literature on intrapericardial solitary fibrous tumours. BMC Cancer 2017, 17: 612. PMID: 28865431, PMCID: PMC5581469, DOI: 10.1186/s12885-017-3574-0.Peer-Reviewed Original ResearchConceptsSolitary fibrous tumorFibrous tumorAsymptomatic patientsPulmonary trunkIncidental findingBackgroundA solitary fibrous tumourRegular MRI follow-upSpindle cell mesenchymal tumorsScreening chest X-rayCoronary computed tomography angiographyAsymptomatic female patientLate gadolinium enhancement imagingMRI follow-upCardiac magnetic resonanceEnlarged cardiac silhouetteLong-term followComputed tomography angiographyFirst-pass perfusionGadolinium-enhanced imagesChest X-rayInversion recovery imagesIntermediate signal intensityProton density-weighted imagesPatternless patternComplete resection