2010
Bisphenol‐A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response
Bromer JG, Zhou Y, Taylor MB, Doherty L, Taylor HS. Bisphenol‐A exposure in utero leads to epigenetic alterations in the developmental programming of uterine estrogen response. The FASEB Journal 2010, 24: 2273-2280. PMID: 20181937, PMCID: PMC3230522, DOI: 10.1096/fj.09-140533.Peer-Reviewed Original ResearchConceptsEpigenetic alterationsCytosine-guanine dinucleotides (CpGs) methylationUtero BPA exposureHomeobox gene HOXA10Developmental programmingDiminished methylationChromatin immunoprecipitationBisulfite sequencingEpigenetic mechanismsDNA methylationPromoter sequencesBPA exposureMethylation profilesExpression patternsGene expressionUterine organogenesisUterine estrogen responsesMethylationNovel mechanismGeneral mechanismPregnant CD-1 miceProtein expressionCD-1 miceHOXA10Expression
2009
WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type
Andikyan V, Taylor HS. WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type. Journal Of Cellular And Molecular Medicine 2009, 13: 4522-4531. PMID: 19017365, PMCID: PMC3107857, DOI: 10.1111/j.1582-4934.2008.00574.x.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorEndometrial NeoplasmsEndometriumEnhancer Elements, GeneticFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenital Neoplasms, FemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansKidneyMullerian DuctsOvarian NeoplasmsPromoter Regions, GeneticProtein BindingRepressor ProteinsUterine Cervical NeoplasmsWT1 ProteinsConceptsHox gene expressionGene expressionHomeobox gene HOXA10HOXA10 expressionEpithelial cell typesHox genesTumor 1 geneRepressor activityHomeobox genesEpithelial enhancersTranscription factorsEmbryonic developmentRegulatory elementsExpression of WT1Enhancer activitySelective repressionRepressor elementAberrant regulationDevelopmental identityOvarian cancer cellsUterine organogenesisCell typesGenesRepressorCancer cells