Maternal CXCR4 deletion results in placental defects and pregnancy loss mediated by immune dysregulation
Lyu F, Burzynski C, Fang Y, Tal A, Chen A, Kisa J, Agrawal K, Kluger Y, Taylor H, Tal R. Maternal CXCR4 deletion results in placental defects and pregnancy loss mediated by immune dysregulation. JCI Insight 2023, 8: e172216. PMID: 37815869, PMCID: PMC10721256, DOI: 10.1172/jci.insight.172216.Peer-Reviewed Original ResearchConceptsCXCR4-deficient micePlacental vascular developmentNK cellsCxcr4 deletionNormal placental vascular developmentPlacental developmentNK cell dysfunctionNK cell expressionNK cell infiltrationNK cell functionRole of CXCR4Cell functionMaternal-fetal interfaceImmune cell functionEarly placental developmentWt CXCR4Immune dysregulationVascular developmentGiant cell layerImmune toleranceCXCR4 expressionPeripheral bloodPregnancy failureCell infiltrationPregnancy lossMATERNAL CXCR4 DELETION RESULTS IN PLACENTAL DEFECTS AND PREGNANCY LOSS MEDIATED BY IMMUNE DYSREGULATION THAT IS RESCUED BY ADOPTIVE TRANSFER OF CXCR4+ BONE MARROW CELLS
Lyu F, Burzynski C, Chen A, Taylor H, Tal R. MATERNAL CXCR4 DELETION RESULTS IN PLACENTAL DEFECTS AND PREGNANCY LOSS MEDIATED BY IMMUNE DYSREGULATION THAT IS RESCUED BY ADOPTIVE TRANSFER OF CXCR4+ BONE MARROW CELLS. Fertility And Sterility 2023, 120: e43-e44. DOI: 10.1016/j.fertnstert.2023.08.153.Peer-Reviewed Original Research