2009
WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type
Andikyan V, Taylor HS. WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type. Journal Of Cellular And Molecular Medicine 2009, 13: 4522-4531. PMID: 19017365, PMCID: PMC3107857, DOI: 10.1111/j.1582-4934.2008.00574.x.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorEndometrial NeoplasmsEndometriumEnhancer Elements, GeneticFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticGenital Neoplasms, FemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansKidneyMullerian DuctsOvarian NeoplasmsPromoter Regions, GeneticProtein BindingRepressor ProteinsUterine Cervical NeoplasmsWT1 ProteinsConceptsHox gene expressionGene expressionHomeobox gene HOXA10HOXA10 expressionEpithelial cell typesHox genesTumor 1 geneRepressor activityHomeobox genesEpithelial enhancersTranscription factorsEmbryonic developmentRegulatory elementsExpression of WT1Enhancer activitySelective repressionRepressor elementAberrant regulationDevelopmental identityOvarian cancer cellsUterine organogenesisCell typesGenesRepressorCancer cells
2003
Transcriptional Repression of Peri-Implantation EMX2 Expression in Mammalian Reproduction by HOXA10
Troy PJ, Daftary GS, Bagot CN, Taylor HS. Transcriptional Repression of Peri-Implantation EMX2 Expression in Mammalian Reproduction by HOXA10. Molecular And Cellular Biology 2003, 23: 1-13. PMID: 12482956, PMCID: PMC140663, DOI: 10.1128/mcb.23.1.1-13.2003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCells, CulturedEmbryonic DevelopmentEndometriumEstradiolFemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansMammalsMenstrual CycleMiceMutationOligonucleotides, AntisensePregnancyProgesteroneRecombinant ProteinsRegulatory Sequences, Nucleic AcidRepressor ProteinsReproductionTranscription FactorsTranscription, GeneticConceptsTranscriptional repressionMammalian reproductionNegative transcriptional regulationDivergent homeobox genesPossible evolutionary implicationsSite-directed mutagenesisTransient transfection assaysNegative regulatory relationshipDrosophila orthologUrogenital tract developmentDirection of regulationTranscriptional regulationEvolutionary implicationsGene relationshipsHomeobox genesTranscriptional activationTranscriptional targetsRegulatory regionsEmpty spiraclesRegulatory relationshipsDeletional analysisDNase IEMX2 mRNAConstitutive expressionNorthern analysis