2012
Increased Hyperoxia-Induced Lung Injury in Nitric Oxide Synthase 2 Null Mice Is Mediated via Angiopoietin 2
Bhandari V, Choo-Wing R, Harijith A, Sun H, Syed MA, Homer RJ, Elias JA. Increased Hyperoxia-Induced Lung Injury in Nitric Oxide Synthase 2 Null Mice Is Mediated via Angiopoietin 2. American Journal Of Respiratory Cell And Molecular Biology 2012, 46: 668-676. PMID: 22227562, PMCID: PMC3359903, DOI: 10.1165/rcmb.2011-0074oc.Peer-Reviewed Original ResearchConceptsHyperoxic acute lung injuryNOS/nitric oxideNitric oxideLung injuryAngiopoietin-2Pathogenesis of HALIAlveolar-capillary protein leakAcute respiratory distress syndromeHyperoxia-Induced Lung InjuryAcute lung injuryRespiratory distress syndromeImportant protective roleCell deathBronchopulmonary dysplasiaDistress syndromeSupplemental oxygenNb miceProtein leakTissue injuryProtective roleNewbornsNull micePremature deathAdult controlsAng2
2011
A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung
Li Z, Choo-Wing R, Sun H, Sureshbabu A, Sakurai R, Rehan VK, Bhandari V. A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung. BMC Molecular And Cell Biology 2011, 12: 54. PMID: 22172122, PMCID: PMC3266206, DOI: 10.1186/1471-2121-12-54.Peer-Reviewed Original ResearchConceptsTransgenic mouse modelTGF-β1Myofibroblast transdifferentiationPulmonary responseMouse modelMurine lungJNK pathwayCell deathEpithelial cellsCultured human lung epithelial cellsFetal rat lung fibroblastsHuman lung epithelial cellsDose-dependent mannerRat lung fibroblastsLung epithelial cellsInhibits cell proliferationImpaired alveolarizationLung developmentCell death mediatorsHyperoxiaInhibition of JNKRoom airLung fibroblastsFibroblast proliferationLung