2024
Leveraging error-prone algorithm-derived phenotypes: Enhancing association studies for risk factors in EHR data
Lu Y, Tong J, Chubak J, Lumley T, Hubbard R, Xu H, Chen Y. Leveraging error-prone algorithm-derived phenotypes: Enhancing association studies for risk factors in EHR data. Journal Of Biomedical Informatics 2024, 157: 104690. PMID: 39004110, DOI: 10.1016/j.jbi.2024.104690.Peer-Reviewed Original ResearchElectronic health recordsElectronic health record dataKaiser Permanente WashingtonEHR-derived phenotypesAssociation studiesHealth recordsColon cancer recurrencePhenotyping errorsComputable phenotypeRisk factorsCancer recurrenceMultiple phenotypesReduce biasImprove estimation accuracySimulation studyBias reductionKaiserReduction of biasBiasEstimation accuracyAssociationStudyOutcomesRiskEstimation efficiency
2023
Social and Behavior Factors of Alzheimer's Disease and Related Dementias: A National Study in the U.S.
Ciciora D, Vásquez E, Valachovic E, Hou L, Zheng Y, Xu H, Jiang X, Huang K, Gabriel K, Deng H, Gallant M, Zhang K. Social and Behavior Factors of Alzheimer's Disease and Related Dementias: A National Study in the U.S. American Journal Of Preventive Medicine 2023, 66: 573-581. PMID: 37995949, DOI: 10.1016/j.amepre.2023.11.017.Peer-Reviewed Original ResearchLevels of disadvantageRisk factorsPrevention strategiesCounty levelCounty-level measuresPrimary prevention strategiesPopulation-based studyHigh school diplomaADRDLifestyle factorsRelated dementiaDisadvantaged countiesSchool diplomaBehavioral factorsNational studyAlzheimer's diseaseDemographic variablesInsufficient sleepFactor of Alzheimer's diseaseCountyRiskSleepEffects of sleepEducationEnvironmental factors
2021
Nonselective beta‐blockers are associated with a lower risk of hepatocellular carcinoma among cirrhotic patients in the United States
Wijarnpreecha K, Li F, Xiang Y, Xu X, Zhu C, Maroufy V, Wang Q, Tao W, Dang Y, Pham H, Zhou Y, Li J, Zhang X, Xu H, Taner C, Yang L, Tao C. Nonselective beta‐blockers are associated with a lower risk of hepatocellular carcinoma among cirrhotic patients in the United States. Alimentary Pharmacology & Therapeutics 2021, 54: 481-492. PMID: 34224163, DOI: 10.1111/apt.16490.Peer-Reviewed Original ResearchConceptsRisk of HCCBeta-blocker groupHepatocellular carcinomaCirrhotic patientsCerner Health Facts databaseCox proportional hazards regressionCumulative HCC incidenceRetrospective cohort studyHealth Facts databasePopulation-based studyProportional hazards regressionKaplan-Meier estimatesEligible patientsCohort studyHCC incidenceFinal cohortHazards regressionHCC riskLower riskPropensity scorePatientsCarvedilolRiskFacts databaseGroup