2018
Toward a normalized clinical drug knowledge base in China—applying the RxNorm model to Chinese clinical drugs
Wang L, Zhang Y, Jiang M, Wang J, Dong J, Liu Y, Tao C, Jiang G, Zhou Y, Xu H. Toward a normalized clinical drug knowledge base in China—applying the RxNorm model to Chinese clinical drugs. Journal Of The American Medical Informatics Association 2018, 25: 809-818. PMID: 29635469, PMCID: PMC7647010, DOI: 10.1093/jamia/ocy020.Peer-Reviewed Original ResearchConceptsChinese patent drugDrug knowledge basePatent drugsClinical drugsChemical drugsChinese drugsManual reviewChinese patent medicineElectronic health record systemsClinical dataChina's health insurance systemHealth record systemsDrug AdministrationHealth insurance systemDrug informationDrugsPatent medicineDrug namesRecord systemPharmacy system
2017
A systematic analysis of FDA-approved anticancer drugs
Sun J, Wei Q, Zhou Y, Wang J, Liu Q, Xu H. A systematic analysis of FDA-approved anticancer drugs. BMC Systems Biology 2017, 11: 87. PMID: 28984210, PMCID: PMC5629554, DOI: 10.1186/s12918-017-0464-7.Peer-Reviewed Original ResearchConceptsDrug-cancer associationsAnticancer drugsTarget-based drugsEfficient anticancer drugsTarget-based approachCancer typesNew anticancer drugsNovel anticancer drugsClinical trial studyPharmaceutical researchTrial studyMore cancer typesUS FoodDrug AdministrationCytotoxic drugsPatient treatmentPotential candidateDrug mechanismsDrugsDrug repurposingSystematic investigationAssociationDrug targetsTyrosine kinaseSystematic discovery
2012
Comparative analysis of pharmacovigilance methods in the detection of adverse drug reactions using electronic medical records
Liu M, Hinz E, Matheny M, Denny J, Schildcrout J, Miller R, Xu H. Comparative analysis of pharmacovigilance methods in the detection of adverse drug reactions using electronic medical records. Journal Of The American Medical Informatics Association 2012, 20: 420-426. PMID: 23161894, PMCID: PMC3628053, DOI: 10.1136/amiajnl-2012-001119.Peer-Reviewed Original ResearchConceptsAdverse drug reactionsElectronic medical recordsProportional reporting ratioVanderbilt University Medical CenterSpontaneous reporting systemDrug-event pairsDrug reactionsMedical recordsMedication ordersAbnormal laboratory resultsDrug-exposed groupNew adverse drug reactionsUniversity Medical CenterSpecific drug administrationReference standardLaboratory resultsUnexposed groupGamma Poisson ShrinkerMedical CenterPatient harmDrug AdministrationPharmacovigilance measuresBayesian confidence propagation neural networkEarly detectionReporting ratio