Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation
Wang LW, Shen H, Nobre L, Ersing I, Paulo JA, Trudeau S, Wang Z, Smith NA, Ma Y, Reinstadler B, Nomburg J, Sommermann T, Cahir-McFarland E, Gygi SP, Mootha VK, Weekes MP, Gewurz BE. Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation. Cell Metabolism 2019, 30: 539-555.e11. PMID: 31257153, PMCID: PMC6720460, DOI: 10.1016/j.cmet.2019.06.003.Peer-Reviewed Original ResearchMeSH KeywordsAminohydrolasesB-LymphocytesCell Transformation, ViralEpstein-Barr Virus InfectionsEpstein-Barr Virus Nuclear AntigensFemaleFolic AcidGlycolysisHEK293 CellsHerpesvirus 4, HumanHumansLymphocyte ActivationMethylenetetrahydrofolate Dehydrogenase (NADP)MitochondriaMultifunctional EnzymesNADPOxidation-ReductionProteomeProto-Oncogene Proteins c-mycSerineConceptsEpstein-Barr virusOne-carbon metabolismSynthesis of serinePost-transplant B cell lymphomasB-cell transformationPrimary human B cellsMitochondrial remodelingTargets MYCRedox defenseNADPH productionB-cell outgrowthCell transformationMetabolic pathwaysB-cell lymphomaPotential therapeutic targetB cell growthMitochondrial NADPHViral proteinsB cell proliferationCell growthNADPH levelsHuman B cellsCell proliferationMTHFD2Infected cells