2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
Kim DH, Park HJ, Lim S, Koo JH, Lee HG, Choi JO, Oh JH, Ha SJ, Kang MJ, Lee CM, Lee CG, Elias JA, Choi JM. Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis. Nature Communications 2018, 9: 503. PMID: 29403003, PMCID: PMC5799380, DOI: 10.1038/s41467-017-02731-6.Peer-Reviewed Original ResearchConceptsT cellsLung metastasesTh1 cellsCHI3L1 expressionFunction of CHI3L1Type 2 inflammationAnti-tumor immunityMelanoma lung metastasisActivated T cellsElicit Th1CTL responsesEnhanced Th1Th2 cellsTherapeutic targetClinical implicationsCytotoxic responseTh1MetastasisTCR stimulationCHI3L1Peptide-siRNA complexLungCellsNegative regulatorImmunity genes
2010
TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C)
Park H, Hong J, Kwon H, Kim Y, Lee K, Kim J, Song S. TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C). Biochemical And Biophysical Research Communications 2010, 396: 721-725. PMID: 20450885, DOI: 10.1016/j.bbrc.2010.04.169.Peer-Reviewed Original ResearchConceptsInterleukin-1 receptor-associated kinase 1TNF-alpha productionKorean mistletoe lectinTNF-alphaTLR4 moleculesMouse macrophagesReceptor-associated kinase 1Mucosal immune cellsTNF-alpha secretionMistletoe lectinMouse peritoneal macrophagesImmune cellsMacrophage activationTLR4Immunomodulatory activityPeritoneal macrophagesMacrophagesCancer cellsUnderlying mechanismKinase 1ActivationDownstream eventsCellsCytokinesAdjuvant