BBB-permeable peptide conjugated cytoplasmic domain of CTLA-4 inhibits Th1 and Th17 responses and pathogenesis of multiple sclerosis
Lim S, Kim W, Kim Y, Lee S, Koo J, Lee J, Kim H, Park H, Kim D, Lee H, Yoon H, Kim J, Shin J, Kim L, Doh J, Kim H, Bothwell A, Lee S, Suh M, Choi J. BBB-permeable peptide conjugated cytoplasmic domain of CTLA-4 inhibits Th1 and Th17 responses and pathogenesis of multiple sclerosis. The Journal Of Immunology 2016, 196: 139.7-139.7. DOI: 10.4049/jimmunol.196.supp.139.7.Peer-Reviewed Original ResearchCentral nervous systemBlood-brain barrierExperimental autoimmune encephalomyelitisMultiple sclerosisT cellsCytotoxic T-lymphocyte antigen-4T-lymphocyte antigen-4T helper 17 (Th17) cellsAbstract Multiple sclerosisCNS inflammatory diseasesInfiltrated T cellsEffector T cellsHelper 17 cellsSevere autoimmune diseaseT helper 1Activated T cellsMOG35-55Autoimmune encephalomyelitisTh17 responsesHelper 1Autoimmune diseasesCytokine productionSevere inflammationAntigen-4Model mice