2021
Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy
Sandhu MRS, Gruenbaum BF, Gruenbaum SE, Dhaher R, Deshpande K, Funaro MC, Lee TW, Zaveri HP, Eid T. Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy. Frontiers In Neurology 2021, 12: 665334. PMID: 33927688, PMCID: PMC8078591, DOI: 10.3389/fneur.2021.665334.Peer-Reviewed Original ResearchMesial temporal lobe epilepsyAstroglial glutamine synthetaseTemporal lobe epilepsyLobe epilepsyIntractable mesial temporal lobe epilepsyAstrocytic glutamine synthetaseDepressive-like featuresPathogenesis of epilepsyType of epilepsyDiscrete brain regionsNeocortical epilepsyHippocampal neuronsEpilepsyBrain regionsGlutamate-ammonia ligaseLaboratory animalsPathogenesisPossible roleExperimental inhibitionGlutamine synthetaseEnzyme glutamine synthetaseDysfunctionSeizuresAstrocytesSyndrome
2007
Neocortical and Thalamic Spread of Amygdala Kindled Seizures
Blumenfeld H, Rivera M, Vasquez JG, Shah A, Ismail D, Enev M, Zaveri HP. Neocortical and Thalamic Spread of Amygdala Kindled Seizures. Epilepsia 2007, 48: 254-262. PMID: 17295618, DOI: 10.1111/j.1528-1167.2006.00934.x.Peer-Reviewed Original ResearchConceptsFrontal cortexMedial thalamusInterictal periodNervous systemSimultaneous field potential recordingsAmygdala-Kindled SeizuresResult of kindlingDevelopment of epilepsyNetwork plasticityField potential recordingsSeizure durationBehavioral seizuresMotor seizuresKindled SeizuresAmygdala kindlingEpilepsy modelSeizuresKindlingPotential recordingsNeocortical circuitsCortexBehavioral severityWeak stimulationThalamusPossible role