Electrical and Pharmacological Stimuli Reveal a Greater Susceptibility for CA3 Network Excitability in Hippocampal Slices from Aged vs. Adult Fischer 344 Rats.
Kanak DJ, Jones RT, Tokhi A, Willingham AL, Zaveri HP, Rose GM, Patrylo PR. Electrical and Pharmacological Stimuli Reveal a Greater Susceptibility for CA3 Network Excitability in Hippocampal Slices from Aged vs. Adult Fischer 344 Rats. Aging And Disease 2011, 2: 318-31. PMID: 22396884, PMCID: PMC3295070.Peer-Reviewed Original ResearchNetwork excitabilityHippocampal slicesMossy fibersAdult male Fischer 344 ratsMale Fischer 344 ratsExcitotoxic glutamate analoguesCA3 networkFischer 344 ratsHigh-affinity receptorField potential activitySpread of excitabilityHilar stimulationProconvulsive effectsEpileptiform activityBath applicationAged CNSClinical dataRenal clearanceAged ratsAdult ratsAge groupsCA3 subregionExcitabilityRatsGlutamate analogue