2020
Oral glutamine supplementation increases seizure severity in a rodent model of mesial temporal lobe epilepsy
Dhaher R, Chen EC, Perez E, Rapuano A, Sandhu MRS, Gruenbaum SE, Deshpande K, Dai F, Zaveri HP, Eid T. Oral glutamine supplementation increases seizure severity in a rodent model of mesial temporal lobe epilepsy. Nutritional Neuroscience 2020, 25: 64-69. PMID: 31900092, PMCID: PMC8970572, DOI: 10.1080/1028415x.2019.1708568.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyOral glutamine supplementationSeverity of seizuresTemporal lobe epilepsyGlutamine supplementationSeizure severityLobe epilepsyRefractory mesial temporal lobe epilepsyMale Sprague-DawleySeizure frequencyConvulsive seizuresSeizure propagationEpilepsy modelSprague-DawleyEffective treatmentRodent modelsSeizuresSupplementationSeverityPotential roleEpilepsyFunction mutationsHippocampusGlutamine synthetaseDays
2007
Neocortical and Thalamic Spread of Amygdala Kindled Seizures
Blumenfeld H, Rivera M, Vasquez JG, Shah A, Ismail D, Enev M, Zaveri HP. Neocortical and Thalamic Spread of Amygdala Kindled Seizures. Epilepsia 2007, 48: 254-262. PMID: 17295618, DOI: 10.1111/j.1528-1167.2006.00934.x.Peer-Reviewed Original ResearchConceptsFrontal cortexMedial thalamusInterictal periodNervous systemSimultaneous field potential recordingsAmygdala-Kindled SeizuresResult of kindlingDevelopment of epilepsyNetwork plasticityField potential recordingsSeizure durationBehavioral seizuresMotor seizuresKindled SeizuresAmygdala kindlingEpilepsy modelSeizuresKindlingPotential recordingsNeocortical circuitsCortexBehavioral severityWeak stimulationThalamusPossible role