2011
Olfactocentric paralimbic cortex morphology in adolescents with bipolar disorder
Wang F, Kalmar JH, Womer FY, Edmiston EE, Chepenik LG, Chen R, Spencer L, Blumberg HP. Olfactocentric paralimbic cortex morphology in adolescents with bipolar disorder. Brain 2011, 134: 2005-2012. PMID: 21666263, PMCID: PMC3122371, DOI: 10.1093/brain/awr124.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBipolar DisorderBrain MappingFemaleHumansImage Processing, Computer-AssistedLimbic SystemMagnetic Resonance ImagingMaleNeural PathwaysPrefrontal CortexYoung AdultConceptsParalimbic corticesBipolar disorderHigh-resolution structural magnetic resonanceGray matter volume differencesVoxel-based morphometry analysisHealthy comparison adolescentsStructural magnetic resonanceSmall volume correctionSuperior temporal gyrusBipolar disorder pathologyNeurovegetative functionsBipolar disorder phenotypeTemporopolar cortexSignificant volume decreaseParalimbic regionsCortex morphologyTemporal gyrusCortexDisordersMorphometry analysisDisorder phenotypesInferior prefrontalCortex structureDisorder pathologyAdolescents
2003
Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder
Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder. JAMA Psychiatry 2003, 60: 1201-1208. PMID: 14662552, DOI: 10.1001/archpsyc.60.12.1201.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmygdalaAtrophyBipolar DisorderBrainChildFemaleHippocampusHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMathematical ComputingMiddle AgedReference ValuesTemporal LobeConceptsHippocampal volumeMedial temporal lobe structuresTemporal lobe structuresBipolar disorderIllness featuresVeterans Affairs Medical CenterLobe structuresRepeated-measures statistical analysisCourse of illnessTotal brain volumeAmygdala volume reductionsBD type IAnatomic magnetic resonanceHealthy comparison subjectsPaucity of dataVolume reductionSignificant volume reductionVolumetric abnormalitiesNeurodegenerative changesIllness durationOutpatient treatmentUniversity HospitalGreater effect sizeMedical CenterHippocampal region