Featured Publications
Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape
Baranowski C, Welsh M, Sham L, Eskandarian H, Lim H, Kieser K, Wagner J, McKinney J, Fantner G, Ioerger T, Walker S, Bernhardt T, Rubin E, Rego E. Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape. ELife 2018, 7: e37516. PMID: 30324906, PMCID: PMC6231781, DOI: 10.7554/elife.37516.Peer-Reviewed Original ResearchConceptsPenicillin-binding proteinsAsymmetric polar growthRod-shaped bacteriaPolar growthPolar elongationShape maintenanceCell wallGenetic relationshipsDrug targetsUnusual crosslinksD-transpeptidasesSingle cellsPeptidoglycanCellsCrosslinksProteinMycobacteriaBacteriaPathogensTypes of crosslinksElongationGrowthMaintenanceTarget
2020
The Conserved Translation Factor LepA Is Required for Optimal Synthesis of a Porin Family in Mycobacterium smegmatis
Fishbein S, Tomasi F, Wolf I, Dulberger C, Wang A, Keshishian H, Wallace L, Carr S, Ioerger T, Rego E, Rubin E. The Conserved Translation Factor LepA Is Required for Optimal Synthesis of a Porin Family in Mycobacterium smegmatis. Journal Of Bacteriology 2020, 203: 10.1128/jb.00604-20. PMID: 33361193, PMCID: PMC8095456, DOI: 10.1128/jb.00604-20.Peer-Reviewed Original ResearchMembrane-associated proteinsMembrane homeostasisCellular processesCell wallMembrane-associated proteomeWhole cell proteomeMajor membrane proteinOuter membrane porinsSteady-state abundanceDrug tolerance phenotypeMembrane proteomePorin familyTolerance phenotypeDeletion mutantsMembrane proteinsTranslation factorsMembrane porinsMajor porinsNutrient uptakeCell wall constituentsMycobacterial cell wallAntibiotic tolerancePorinProteomeDrug targets