2001
Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production
Perez L, Rinder H, Wang C, Tracey J, Maun N, Krause D. Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production. Blood 2001, 97: 1635-1643. PMID: 11238102, DOI: 10.1182/blood.v97.6.1635.Peer-Reviewed Original ResearchConceptsPeripheral blood stem cellsHuman peripheral blood stem cellsPlatelet productionVivo modelStudy of megakaryocytopoiesisCFU-MKHuman megakaryocytopoiesisImmunodeficient miceBone marrowHuman plateletsExogenous cytokinesNOD/SCID miceHuman hematopoiesisBlood stem cellsHuman cell engraftmentPlatelet developmentNonobese diabetic/Lymphoid lineageStem cellsHuman blood CD34MegakaryocytopoiesisPeripheral bloodCytokine stimulationMurine recipientsThrombin stimulation
1992
The Significance of Platelets with Increased RNA Content (Reticulated Platelets) A Measure of the Rate of Thrombopoiesis
Ault K, Rinder H, Mitchell J, Carmody M, Vary C, Hillman R. The Significance of Platelets with Increased RNA Content (Reticulated Platelets) A Measure of the Rate of Thrombopoiesis. American Journal Of Clinical Pathology 1992, 98: 637-646. PMID: 1281383, DOI: 10.1093/ajcp/98.6.637.Peer-Reviewed Original ResearchConceptsPlatelet-associated immunoglobulinsRate of thrombopoiesisThrombocytopenic patientsAbsolute numberSignificance of plateletsSubset of patientsNucleic acid contentAnti-platelet antiserumStudies of micePeripheral destructionPlatelet countReticulocyte responseSubnormal levelsNormal rangePatientsAverage absolute numberFlow cytometric measurementsThrombopoietic responseNormal levelsPlatelet increaseElevated levelsFluorescent dye thiazole orangeImmunoglobulinPlateletsCytometric measurements