1999
Role of C3 Cleavage in Monocyte Activation During Extracorporeal Circulation
Rinder C, Rinder H, Johnson K, Smith M, Lee D, Tracey J, Polack G, Higgins P, Yeh C, Smith MD B. Role of C3 Cleavage in Monocyte Activation During Extracorporeal Circulation. Circulation 1999, 100: 553-558. PMID: 10430771, DOI: 10.1161/01.cir.100.5.553.Peer-Reviewed Original ResearchConceptsMonocyte activationC5b-9CD11b upregulationComplement inhibitionExtracorporeal circulationPlatelet activationTerminal complement inhibitionMonocyte-platelet conjugatesComplement regulatory protein CD46Early complement componentsPMN elastase releaseGeneration of C3aMicrograms/mLCardiopulmonary bypassBlood cell activationPMN activationElastase releaseCell activationHuman volunteersMicrograms/Complement activationPrevents plateletComplement componentsWhole bloodCommon pathway
1995
Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming
Harris S, Rinder C, Rinder H, Tracey J, Smith B, Hines R. Nitroprusside Inhibition of Platelet Function Is Transient and Reversible by Catecholamine Priming. Anesthesiology 1995, 83: 1145-1152.. PMID: 8533905, DOI: 10.1097/00000542-199512000-00003.Peer-Reviewed Original ResearchConceptsAlpha-granule releaseSodium nitroprusside infusionSodium nitroprussidePlatelet functionNitroprusside infusionPlatelet aggregationSodium nitroprusside administrationP-selectin expressionPlatelet-rich plasmaMeasures of plateletIntravenous crystalloidImpaired coagulationNitroprusside administrationAntiplatelet effectEpinephrine pretreatmentNormal volunteersVivo findingsHuman volunteersNitroprussideVivo inhibitionVitro inhibitionInhibitory effectSignificant inhibitionRapid reversibilityTime course