2022
Impact of radiotherapy delay following biopsy for patients with unresected glioblastoma.
Gao S, Jin L, Moliterno J, Corbin ZA, Bindra RS, Contessa JN, Yu JB, Park HS. Impact of radiotherapy delay following biopsy for patients with unresected glioblastoma. Journal Of Neurosurgery 2022, 138: 610-620. PMID: 35907197, DOI: 10.3171/2022.5.jns212761.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyBrain NeoplasmsGlioblastomaHumansProportional Hazards ModelsRadiotherapy, AdjuvantConceptsWeeks of biopsyOverall survivalCox proportional hazards regression modelingProportional hazards regression modelingNational Cancer DatabaseInitiation of radiotherapyKaplan-Meier methodWorse overall survivalWilcoxon rank sum testEffects of confoundersRank sum testUnresected diseaseAdjuvant radiotherapyConcurrent chemotherapyMedian intervalMultivariable analysisRadiotherapy delayCancer DatabaseClinical dataBiopsyPatientsLate initiationAggressive natureRadiotherapyPotential association
2016
Concurrent chemoradiotherapy versus radiotherapy alone for “biopsy‐only” glioblastoma multiforme
Kole AJ, Park HS, Yeboa DN, Rutter CE, Corso CD, Aneja S, Lester-Coll NH, Mancini BR, Knisely JP, Yu JB. Concurrent chemoradiotherapy versus radiotherapy alone for “biopsy‐only” glioblastoma multiforme. Cancer 2016, 122: 2364-2370. PMID: 27172136, DOI: 10.1002/cncr.30063.Peer-Reviewed Original ResearchConceptsPropensity score-matched analysisConcurrent chemoradiotherapySignificant OS benefitOverall survivalGlioblastoma multiformeOS benefitUS National Cancer Data BaseMultivariable Cox proportional hazards regressionNational Cancer Data BaseCox proportional hazards regressionImproved overall survivalStandard postoperative therapyProportional hazards regressionMultivariable logistic regressionLog-rank testStandard of careChi-square testClinicopathologic predictorsPostoperative therapySurgical resectionImproved survivalMedian ageMultivariable analysisHazards regressionNational cohort
2012
Immortal Time Bias: A Frequently Unrecognized Threat to Validity in the Evaluation of Postoperative Radiotherapy
Park HS, Gross CP, Makarov DV, Yu JB. Immortal Time Bias: A Frequently Unrecognized Threat to Validity in the Evaluation of Postoperative Radiotherapy. International Journal Of Radiation Oncology • Biology • Physics 2012, 83: 1365-1373. PMID: 22342097, DOI: 10.1016/j.ijrobp.2011.10.025.Peer-Reviewed Original ResearchConceptsSequential landmark analysesPostoperative radiotherapyImmortal time biasLandmark analysisTumor typesEnd Results (SEER) databaseObservational cohort studyTime biasObservation cohortCohort studyHazard ratioProspective trialImproved survivalResults databaseConditional survivalRoutine useSurvivalApparent benefitRadiotherapyCohort