2023
In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer’s disease
Zhang J, Wang J, Xu X, You Z, Huang Q, Huang Y, Guo Q, Guan Y, Zhao J, Liu J, Xu W, Deng Y, Xie F, Li B. In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer’s disease. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 977-988. PMID: 36718002, PMCID: PMC10196742, DOI: 10.1177/0271678x231153730.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseCognitionCognitive DysfunctionHumansMagnetic Resonance ImagingPyridinesConceptsMiddle frontal gyrusAlzheimer's diseaseSynaptic densityMild cognitive impairmentSynapse lossCognitive impairmentCaudal middle frontal gyrusFunctional connectivityLower synaptic densityMajor pathological changesRight insular cortexStructural connectivity alterationsRight middle frontal gyrusWhite matter tractsSynaptic alterationsBilateral cortexConnectivity alterationsInsular cortexAD groupPathological changesConnectivity dysfunctionCognitive declineCognitive functionFunctional MRIDisease
2003
Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum
Martinez D, Slifstein M, Broft A, Mawlawi O, Hwang DR, Huang Y, Cooper T, Kegeles L, Zarahn E, Abi-Dargham A, Haber SN, Laruelle M. Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum. Cerebrovascular And Brain Metabolism Reviews 2003, 23: 285-300. PMID: 12621304, DOI: 10.1097/01.wcb.0000048520.34839.1a.Peer-Reviewed Original ResearchConceptsD2 receptor availabilityPositron emission tomographyReceptor availabilityHuman striatumFunctional subdivisionsDopamine releaseAssociative regionsSensorimotor regionsEmission tomographyAmphetamine-induced dopamine releaseIntegration of limbicMesolimbic dopamine transmissionDopamine D2 receptorsVoxel-based analysisPriming bolusSensorimotor subdivisionsAmphetamine administrationMotor functionStriatal functionD2 receptorsIntravenous administrationStriatal subregionsVentral midbrainHealthy volunteersDopamine transmission
2001
Differential Occupancy of Somatodendritic and Postsynaptic 5HT1A Receptors by Pindolol: A Dose-Occupancy Study with [11C]WAY 100635 and Positron Emission Tomography in Humans
Martinez D, Hwang D, Mawlawi O, Slifstein M, Kent J, Simpson N, Parsey R, Hashimoto T, Huang Y, Shinn A, Van Heertum R, Abi-Dargham A, Caltabiano S, Malizia A, Cowley H, Mann J, Laruelle M. Differential Occupancy of Somatodendritic and Postsynaptic 5HT1A Receptors by Pindolol: A Dose-Occupancy Study with [11C]WAY 100635 and Positron Emission Tomography in Humans. Neuropsychopharmacology 2001, 24: 209-229. PMID: 11166513, DOI: 10.1016/s0893-133x(00)00187-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsBrainHumansKineticsMagnetic Resonance ImagingMaleMood DisordersPindololPiperazinesPyridinesRaphe NucleiReceptors, NeurotransmitterReceptors, SerotoninReceptors, Serotonin, 5-HT1Selective Serotonin Reuptake InhibitorsSynaptic TransmissionTomography, Emission-ComputedConceptsDorsal raphe nucleusPositron emission tomographyClinical studiesSelective serotonin reuptake inhibitor (SSRI) therapyPlacebo-controlled clinical studySerotonin reuptake inhibitor therapyEmission tomographyAbility of pindololPindolol augmentationAntidepressant therapyAntidepressant treatmentClinical responseInhibitor therapyRaphe nucleusScan 3Scan 4Therapeutic effectHealthy volunteersScan 2Vivo selectivityPindololAutoreceptorsSSRIsTherapyInconsistent results
1999
Pet imaging of serotonin 1A receptor binding in depression
Drevets W, Frank E, Price J, Kupfer D, Holt D, Greer P, Huang Y, Gautier C, Mathis C. Pet imaging of serotonin 1A receptor binding in depression. Biological Psychiatry 1999, 46: 1375-1387. PMID: 10578452, DOI: 10.1016/s0006-3223(99)00189-4.Peer-Reviewed Original ResearchConceptsFamilial mood disordersReceptor BPPostmortem studiesMood disordersMesiotemporal cortexMidbrain rapheSerotonin 1A receptor systemBrain regionsPET imagingPrevious postmortem studiesSerotonin 1A receptorMultiple brain regionsHistopathological changesHealthy controlsBP valuesMajor depressionDepressed phasePostcentral gyrusClinical conditionsOccipital cortexBipolar relativesBipolar depressivesReceptor radioligandDepressed subjectsNormal baseline