Comparative Evaluation in Nonhuman Primates of Five PET Radiotracers for Imaging the Serotonin Transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM
Huang Y, Hwang D, Narendran R, Sudo Y, Chatterjee R, Bae S, Mawlawi O, Kegeles L, Wilson A, Kung H, Laruelle M. Comparative Evaluation in Nonhuman Primates of Five PET Radiotracers for Imaging the Serotonin Transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 1377-1398. DOI: 10.1097/00004647-200211000-00011.Peer-Reviewed Original ResearchPositron emission tomographySerotonin transporterSERT availabilitySlow brain kineticsNonspecific equilibrium partition coefficientN-dimethylVivo positron emission tomographyEquilibrium partition coefficientHigher free fractionKinetic uptakeRegional distribution volumesPartition coefficientsSuperior radiotracerBrain uptakeBrain kineticsOne-tissue compartment modelLimbic systemSERT imagingBrain regionsDistribution volumeEmission tomographyKinetic modelingNew radiotracersMeasurement of affinityPromising agent