2024
First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding
Drake L, Wu Y, Naganawa M, Asch R, Zheng C, Najafzadeh S, Pracitto R, Lindemann M, Li S, Ropchan J, Labaree D, Emery P, Dias M, Henry S, Nabulsi N, Matuskey D, Hillmer A, Gallezot J, Carson R, Cai Z, Huang Y. First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266470. PMID: 38360052, PMCID: PMC10924160, DOI: 10.2967/jnumed.123.266470.Peer-Reviewed Original ResearchFirst-in-human studyPlasma free fractionTime-activity curvesCentrum semiovaleNonhuman primate's resultsFirst-in-humanFree fractionNondisplaceable binding potentialRegional time-activity curvesLow nonspecific uptakeRegional distribution volumesHigh-resolution research tomograph scannerTest-retest reproducibilityCerebral blood flowSynaptic vesicle glycoprotein 2AHealthy volunteersArterial input functionNonspecific uptakePET imaging probeDistribution volumeSynapse densityIndividual MR imagesHighest specific bindingMR imagingPET imaging
2002
Comparative Evaluation in Nonhuman Primates of Five PET Radiotracers for Imaging the Serotonin Transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM
Huang Y, Hwang D, Narendran R, Sudo Y, Chatterjee R, Bae S, Mawlawi O, Kegeles L, Wilson A, Kung H, Laruelle M. Comparative Evaluation in Nonhuman Primates of Five PET Radiotracers for Imaging the Serotonin Transporters: [11C]McN 5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 1377-1398. DOI: 10.1097/00004647-200211000-00011.Peer-Reviewed Original ResearchPositron emission tomographySerotonin transporterSERT availabilitySlow brain kineticsNonspecific equilibrium partition coefficientN-dimethylVivo positron emission tomographyEquilibrium partition coefficientHigher free fractionKinetic uptakeRegional distribution volumesPartition coefficientsSuperior radiotracerBrain uptakeBrain kineticsOne-tissue compartment modelLimbic systemSERT imagingBrain regionsDistribution volumeEmission tomographyKinetic modelingNew radiotracersMeasurement of affinityPromising agent