2014
Su1488 Effect of Native and Acetylated High Amylose Maize Starch on Fecal pH and Short Chain Fatty Acid Concentrations in a Cohort of Children in Southern India
Balamurugan R, Balachandar G, Dharmalingam T, Mortimer E, Gopalsamy G, Woodman R, Alpers D, Manary M, Binder H, Brown I, Young G, Ramakrishna B. Su1488 Effect of Native and Acetylated High Amylose Maize Starch on Fecal pH and Short Chain Fatty Acid Concentrations in a Cohort of Children in Southern India. Gastroenterology 2014, 146: s-482. DOI: 10.1016/s0016-5085(14)61731-5.Peer-Reviewed Original Research
2013
Identification of Functionally Distinct Na-HCO3 Co-Transporters in Colon
Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM. Identification of Functionally Distinct Na-HCO3 Co-Transporters in Colon. PLOS ONE 2013, 8: e62864. PMID: 23690961, PMCID: PMC3653958, DOI: 10.1371/journal.pone.0062864.Peer-Reviewed Original ResearchConceptsNa-HCO3 cotransportDistal colonProximal colonNBC activityNBC isoformsRat colonColonic epithelial cellsCrypt glandsSensitive transporterHCO3- secretionColonHCO3-dependent mechanismEpithelial cellsSaturable processHOE694Isoform 1Basolateral membraneCotransportPCR analysisNorthern blotDIDSMolecular studiesMolecular identityApparent KiCritical role
2012
Preventive Strategy Against Infectious Diarrhea—A Holistic Approach
Motarjemi Y, Steffen R, Binder HJ. Preventive Strategy Against Infectious Diarrhea—A Holistic Approach. Gastroenterology 2012, 143: 516-519. PMID: 22925951, DOI: 10.1053/j.gastro.2012.07.021.Peer-Reviewed Original Research
2011
Radiation decreases murine small intestinal HCO3− secretion
Zhang K, Yin L, Zhang M, Parker MD, Binder HJ, Salzman P, Zhang L, Okunieff P, Vidyasagar S. Radiation decreases murine small intestinal HCO3− secretion. International Journal Of Radiation Biology 2011, 87: 878-888. PMID: 21689053, DOI: 10.3109/09553002.2011.583314.Peer-Reviewed Original ResearchConceptsNon-irradiated miceAnion secretionBALB/c miceUpper gastrointestinal tractInhibition of basalWestern blot analysisElectrolyte imbalanceInsensitive currentsC miceJejunal tissueCyclic adenosine monophosphateCotransporter expressionMiceSecretionProtein levelsDiarrheaBlot analysisAdenosine monophosphateCesium-137 sourceBasalFree solutionInhibition
2010
Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea
Binder HJ. Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea. Annual Review Of Physiology 2010, 72: 297-313. PMID: 20148677, DOI: 10.1146/annurev-physiol-021909-135817.Peer-Reviewed Original ResearchConceptsShort-chain fatty acidsColonic microbiotaProduction of SCFAsOral rehydration solutionYears of ageShort-chain fatty acid transportAdministration of PEGColonic epithelial cellsAcute diarrheaRehydration solutionSCFA synthesisCyclic AMP-independent processFatty acid transportDiarrheaApical membrane NaFluid absorptionEpithelial cellsSCFA productionAcid transportORSFatty acidsMicrobiotaMembrane NaStoolColon
2009
W1646 DSS-Induced Colonic Inflammation Inhibits HCO3-Stimulated But Not Butyrate-Stimulated Na Absorption in Rat Distal Colon
Shanmugam N, Kashgarian M, Binder H, Rajendran V. W1646 DSS-Induced Colonic Inflammation Inhibits HCO3-Stimulated But Not Butyrate-Stimulated Na Absorption in Rat Distal Colon. Gastroenterology 2009, 136: a-709. DOI: 10.1016/s0016-5085(09)63270-4.Peer-Reviewed Original ResearchCHAPTER 44 INTESTINAL FLUID AND ELECTROLYTE MOVEMENT
Binder H. CHAPTER 44 INTESTINAL FLUID AND ELECTROLYTE MOVEMENT. 2009, 933-948. DOI: 10.1016/b978-1-4160-3115-4.50047-0.Peer-Reviewed Original ResearchCHAPTER 42 GASTRIC FUNCTION
Binder H. CHAPTER 42 GASTRIC FUNCTION. 2009, 895-911. DOI: 10.1016/b978-1-4160-3115-4.50045-7.Peer-Reviewed Original ResearchCHAPTER 41 ORGANIZATION OF THE GASTROINTESTINAL SYSTEM
Binder H. CHAPTER 41 ORGANIZATION OF THE GASTROINTESTINAL SYSTEM. 2009, 883-894. DOI: 10.1016/b978-1-4160-3115-4.50044-5.ChaptersCHAPTER 45 NUTRIENT DIGESTION AND ABSORPTION
Binder H, Reuben A. CHAPTER 45 NUTRIENT DIGESTION AND ABSORPTION. 2009, 949-979. DOI: 10.1016/b978-1-4160-3115-4.50048-2.Peer-Reviewed Original ResearchOrganization of the gastrointestinal system
Binder, H.J.: Organization of the gastrointestinal system. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 883-894, 2009.Peer-Reviewed Original ResearchGastric Function
Binder, H.J.: Gastric Function. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 895-911, 2009.Peer-Reviewed Original ResearchNutrient digestion and absorption
Binder, H.J.: Nutrient digestion and absorption. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 949-979, 2009.Peer-Reviewed Original ResearchIntestinal fluid and electrolyte movement
Binder. H.J.: Intestinal fluid and electrolyte movement. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 933-948, 2009.Peer-Reviewed Original Research
2008
A Randomized Controlled Trial of Glucose versus Amylase Resistant Starch Hypo-Osmolar Oral Rehydration Solution for Adult Acute Dehydrating Diarrhea
Ramakrishna BS, Subramanian V, Mohan V, Sebastian BK, Young GP, Farthing MJ, Binder HJ. A Randomized Controlled Trial of Glucose versus Amylase Resistant Starch Hypo-Osmolar Oral Rehydration Solution for Adult Acute Dehydrating Diarrhea. PLOS ONE 2008, 3: e1587. PMID: 18270575, PMCID: PMC2217593, DOI: 10.1371/journal.pone.0001587.Peer-Reviewed Original ResearchConceptsHypo-osmolar ORSOral rehydration solutionCholera-like diarrheaDiarrhea durationDehydrating diarrheaFecal weightRehydration solutionDuration of diarrheaTertiary referral hospitalSevere dehydrating diarrheaSevere watery diarrheaAmylase-resistant starchAcute dehydrating diarrheaSimilar significant differencesORS intakeORS therapyControlled TrialsIntravenous therapyReferral hospitalAppropriate antibioticsRehydration therapyWatery diarrheaStool weightSubgroup analysisClinical trialsDisorders of absorption
Binder, H.J.: Disorders of absorption. In: Harrison’s Principles of Internal Medicine. Ed. Fauci, A. Kasper, D.L., McGraw Hill, New York. 17th ed. (in press).Peer-Reviewed Original Research
2007
Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum
Subramanya SB, Rajendran VM, Srinivasan P, Kumar N, Ramakrishna BS, Binder HJ. Differential regulation of cholera toxin-inhibited Na-H exchange isoforms by butyrate in rat ileum. AJP Gastrointestinal And Liver Physiology 2007, 293: g857-g863. PMID: 17690171, DOI: 10.1152/ajpgi.00462.2006.Peer-Reviewed Original ResearchCa-aktivierte K-Kanäle mittlerer Leitfähigkeit (IK): Klonierung und funktionelle Charakterisierung unterschiedlicher Isoformen in der apikalen und basolateralen Membran von Kolonepithelzellen
Barmeyer C, Rahner C, Yang Y, Sigworth F, Binder H, Rajendran V. Ca-aktivierte K-Kanäle mittlerer Leitfähigkeit (IK): Klonierung und funktionelle Charakterisierung unterschiedlicher Isoformen in der apikalen und basolateralen Membran von Kolonepithelzellen. Zeitschrift Für Gastroenterologie 2007, 45 DOI: 10.1055/s-2007-988400.Peer-Reviewed Original ResearchEnteric Flora in Health and Disease
Binder H, Floch M. Enteric Flora in Health and Disease. Journal Of Clinical Gastroenterology 2007, 41: s1. DOI: 10.1097/mcg.0b013e31803d16fd.Peer-Reviewed Original Research
2006
Evaluation of Oral Rehydration Solution by Whole‐Gut Perfusion in Rats: Effect of Osmolarity, Sodium Concentration and Resistant Starch
Subramanya S, Ramakrishna BS, Binder HJ, Farthing MJ, Young GP. Evaluation of Oral Rehydration Solution by Whole‐Gut Perfusion in Rats: Effect of Osmolarity, Sodium Concentration and Resistant Starch. Journal Of Pediatric Gastroenterology And Nutrition 2006, 43: 568-575. PMID: 17130730, DOI: 10.1097/01.mpg.0000239998.43141.b2.Peer-Reviewed Original ResearchConceptsOsmolarity oral rehydration solutionGlucose-ORSOral rehydration solutionNet water absorptionRehydration solutionWhole-gut perfusionSmall bowel absorptionColonic fluid absorptionSeverity of diarrheaAmylase-resistant starchSteady-state perfusionEscherichia coli heat-stable enterotoxinColi heat-stable enterotoxinBowel perfusionBowel absorptionSevere diarrheaDifferent etiologiesHigher net absorptionSegmental perfusionWistar ratsHeat-stable enterotoxinClinical practiceNet secretionExperimental animalsPerfusion