2012
Preventive Strategy Against Infectious Diarrhea—A Holistic Approach
Motarjemi Y, Steffen R, Binder HJ. Preventive Strategy Against Infectious Diarrhea—A Holistic Approach. Gastroenterology 2012, 143: 516-519. PMID: 22925951, DOI: 10.1053/j.gastro.2012.07.021.Peer-Reviewed Original Research
2010
Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea
Binder HJ. Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea. Annual Review Of Physiology 2010, 72: 297-313. PMID: 20148677, DOI: 10.1146/annurev-physiol-021909-135817.Peer-Reviewed Original ResearchConceptsShort-chain fatty acidsColonic microbiotaProduction of SCFAsOral rehydration solutionYears of ageShort-chain fatty acid transportAdministration of PEGColonic epithelial cellsAcute diarrheaRehydration solutionSCFA synthesisCyclic AMP-independent processFatty acid transportDiarrheaApical membrane NaFluid absorptionEpithelial cellsSCFA productionAcid transportORSFatty acidsMicrobiotaMembrane NaStoolColon
2008
A Randomized Controlled Trial of Glucose versus Amylase Resistant Starch Hypo-Osmolar Oral Rehydration Solution for Adult Acute Dehydrating Diarrhea
Ramakrishna BS, Subramanian V, Mohan V, Sebastian BK, Young GP, Farthing MJ, Binder HJ. A Randomized Controlled Trial of Glucose versus Amylase Resistant Starch Hypo-Osmolar Oral Rehydration Solution for Adult Acute Dehydrating Diarrhea. PLOS ONE 2008, 3: e1587. PMID: 18270575, PMCID: PMC2217593, DOI: 10.1371/journal.pone.0001587.Peer-Reviewed Original ResearchConceptsHypo-osmolar ORSOral rehydration solutionCholera-like diarrheaDiarrhea durationDehydrating diarrheaFecal weightRehydration solutionDuration of diarrheaTertiary referral hospitalSevere dehydrating diarrheaSevere watery diarrheaAmylase-resistant starchAcute dehydrating diarrheaSimilar significant differencesORS intakeORS therapyControlled TrialsIntravenous therapyReferral hospitalAppropriate antibioticsRehydration therapyWatery diarrheaStool weightSubgroup analysisClinical trials
2006
Amylase‐Resistant Starch as Adjunct to Oral Rehydration Therapy in Children with Diarrhea
Raghupathy P, Ramakrishna BS, Oommen SP, Ahmed MS, Priyaa G, Dziura J, Young GP, Binder HJ. Amylase‐Resistant Starch as Adjunct to Oral Rehydration Therapy in Children with Diarrhea. Journal Of Pediatric Gastroenterology And Nutrition 2006, 42: 362-368. PMID: 16641573, DOI: 10.1097/01.mpg.0000214163.83316.41.Peer-Reviewed Original ResearchConceptsOral rehydration solutionAmylase-resistant starchGlucose-ORSDuration of diarrheaStool weightAcute diarrheaStandard treatmentFluid absorptionG-ORS groupMean stool weightIntravenous fluid therapyAcute watery diarrheaOral rehydration therapySeverity of diarrheaTreatment of diarrheaShort-chain fatty acidsColonic sodiumEvaluable dataRehydration therapyTreatment failureFluid therapyWatery diarrheaRehydration solutionIntestinal sodiumDiarrhea
2000
Amylase-Resistant Starch plus Oral Rehydration Solution for Cholera
Ramakrishna BS, Venkataraman S, Srinivasan P, Dash P, Young G, Binder H. Amylase-Resistant Starch plus Oral Rehydration Solution for Cholera. New England Journal Of Medicine 2000, 342: 308-313. PMID: 10655529, DOI: 10.1056/nejm200002033420502.Peer-Reviewed Original ResearchConceptsOral rehydration solutionDuration of diarrheaOral rehydration therapyStandard therapyAmylase-resistant starchRehydration solutionFecal weightRehydration therapyStandard oral rehydration therapyMean fecal weightResistant starch groupStandard therapy groupPrimary end pointShort-chain fatty acidsMean durationFecal excretionDiarrheaTherapySodium absorptionEnd pointFluid lossLength of timeCholeraFatty acidsDurationColonic H-K-ATPase α- and β-subunits express ouabain-insensitive H-K-ATPase
Sangan P, Thevananther S, Sangan S, Rajendran V, Binder H. Colonic H-K-ATPase α- and β-subunits express ouabain-insensitive H-K-ATPase. American Journal Of Physiology - Cell Physiology 2000, 278: c182-c189. PMID: 10644526, DOI: 10.1152/ajpcell.2000.278.1.c182.Peer-Reviewed Original Research
1998
Heterogeneity of Intestinal Transport
Binder H. Heterogeneity of Intestinal Transport. Digestion 1998, 59: 392-394. PMID: 9693215, DOI: 10.1159/000007495.Peer-Reviewed Original ResearchResistant starch and SCFA: Adjunct to ORS?
Binder H, Ramakrishna BS. Resistant starch and SCFA: Adjunct to ORS? Gastroenterology 1998, 115: 512. PMID: 9758546, DOI: 10.1016/s0016-5085(98)70237-9.Peer-Reviewed Original Research
1995
Diagnostic utility of contrast echocardiography and lung perfusion scan in patients with hepatopulmonary syndrome
Abrams G, Jaffe C, Hoffer P, Binder H, Fallon M. Diagnostic utility of contrast echocardiography and lung perfusion scan in patients with hepatopulmonary syndrome. Gastroenterology 1995, 109: 1283-1288. PMID: 7557096, DOI: 10.1016/0016-5085(95)90589-8.Peer-Reviewed Original ResearchConceptsLung perfusion scanHepatopulmonary syndromeIntrapulmonary vascular dilatationEchocardiogram resultsPerfusion scanContrast echocardiographyVascular dilatationDiagnosis of HPSBiopsy-proven cirrhosisConcurrent cardiopulmonary diseaseIntrinsic lung diseaseLung scan resultsPositive contrast echocardiogramChest radiograph abnormalitiesArterial blood gasesGas exchange abnormalitiesScan resultsUseful screening testIntrapulmonary vasodilatationPositive echocardiogramRadiograph abnormalitiesConsecutive outpatientsCardiopulmonary diseaseLung diseasePositive lung
1994
Factitious Diarrhea Detected by Measurement of Stool Osmolality
Topazian M, Binder H. Factitious Diarrhea Detected by Measurement of Stool Osmolality. New England Journal Of Medicine 1994, 330: 1418-1419. PMID: 8159195, DOI: 10.1056/nejm199405193302004.Peer-Reviewed Original Research
1992
The gastroenterologist's osmotic gap: Fact or fiction?
Binder H. The gastroenterologist's osmotic gap: Fact or fiction? Gastroenterology 1992, 103: 702-704. PMID: 1634087, DOI: 10.1016/0016-5085(92)90870-5.Peer-Reviewed Original ResearchGastrin and colorectal cancer
Yapp R, Modlin I, Kumar R, Binder H, Dubrow R. Gastrin and colorectal cancer. Digestive Diseases And Sciences 1992, 37: 481-484. PMID: 1551333, DOI: 10.1007/bf01307566.Peer-Reviewed Original Research
1990
Pathophysiology of acute diarrhea
Binder H. Pathophysiology of acute diarrhea. The American Journal Of Medicine 1990, 88: s2-s4. PMID: 2356845, DOI: 10.1016/0002-9343(90)90267-h.Peer-Reviewed Original ResearchConceptsFluid absorptionAcute infectious diarrheaMajor health problemSpecific pathogenic mechanismsElectrolyte movementStool consistencyStool frequencyIntestinal motilityStool volumeAcute diarrheaIntestinal secretionInfectious diarrheaAntidiarrheal agentsWater excretionDiarrheaPathogenic mechanismsInfectious agentsHealth problemsIntestinal tractEpithelial cellsTissue invasionLuminal osmolalitySymptomsEnterotoxin productionSigns
1987
Corticosteroids and intestinal ion transport
Sandle G, Binder H. Corticosteroids and intestinal ion transport. Gastroenterology 1987, 93: 188-196. PMID: 3556304, DOI: 10.1016/0016-5085(87)90333-7.Peer-Reviewed Original Research
1986
Electrophysiology of the human colon: evidence of segmental heterogeneity.
Sandle G, Wills N, Alles W, Binder H. Electrophysiology of the human colon: evidence of segmental heterogeneity. Gut 1986, 27: 999. PMID: 3758827, PMCID: PMC1433802, DOI: 10.1136/gut.27.9.999.Peer-Reviewed Original ResearchEffect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis.
Sandle G, Hayslett J, Binder H. Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis. Gut 1986, 27: 309. PMID: 3699552, PMCID: PMC1433405, DOI: 10.1136/gut.27.3.309.Peer-Reviewed Original ResearchConceptsActive ulcerative colitisInactive ulcerative colitisUlcerative colitisControl subjectsPharmacological dosesIntravenous administrationNet sodiumAcute ulcerative colitisAnti-inflammatory actionEffects of glucocorticoidsNet sodium absorptionColonic sodiumRectal pdAcute increaseAcute effectsColitisHydrocortisone hemisuccinateNormal subjectsPatientsGlucocorticoid hormonesSodium absorptionNet electrolyteGlucocorticoidsSimilar increaseSimilar changes
1984
Apical membrane properties and amiloride binding kinetics of the human descending colon
Wills N, Alles W, Sandle G, Binder H. Apical membrane properties and amiloride binding kinetics of the human descending colon. American Journal Of Physiology 1984, 247: g749-g757. PMID: 6095681, DOI: 10.1152/ajpgi.1984.247.6.g749.Peer-Reviewed Original ResearchThe Pathophysiology of Diarrhea
Binder H. The Pathophysiology of Diarrhea. Hospital Practice 1984, 19: 107-118. PMID: 6148347, DOI: 10.1080/21548331.1984.11702924.Peer-Reviewed Original ResearchColonic potassium transport.
Foster E, Hayslett J, Binder H. Colonic potassium transport. Kroc Foundation Series 1984, 17: 47-63. PMID: 6096514.Peer-Reviewed Original Research
1982
Increased risk of nephrolithiasis in patients with steatorrhea
Dharmsathaphorn K, Freeman D, Binder H, Dobbins J. Increased risk of nephrolithiasis in patients with steatorrhea. Digestive Diseases And Sciences 1982, 27: 401-405. PMID: 7075427, DOI: 10.1007/bf01295647.Peer-Reviewed Original ResearchConceptsIleal diseaseRisk of nephrolithiasisIncidence of nephrolithiasisRisk factorsRelative riskLonger risk factorsSerum uric acidFecal fat analysisUrine specific gravityControl patientsAdult patientsMale patientsSerum calciumMale sexDietary oxalateSteatorrheaFecal fatPatientsNephrolithiasisDiseaseUric acidDiarrheaHyperoxaluriaRiskSex