2010
Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea
Binder HJ. Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea. Annual Review Of Physiology 2010, 72: 297-313. PMID: 20148677, DOI: 10.1146/annurev-physiol-021909-135817.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological Transport, ActiveColonCyclic AMPDiarrheaFatty Acids, VolatileFluid TherapyHumansIntestinal AbsorptionOsmotic PressureSodiumSodium-Hydrogen ExchangersConceptsShort-chain fatty acidsColonic microbiotaProduction of SCFAsOral rehydration solutionYears of ageShort-chain fatty acid transportAdministration of PEGColonic epithelial cellsAcute diarrheaRehydration solutionSCFA synthesisCyclic AMP-independent processFatty acid transportDiarrheaApical membrane NaFluid absorptionEpithelial cellsSCFA productionAcid transportORSFatty acidsMicrobiotaMembrane NaStoolColon
1991
Mechanism of short-chain fatty acid uptake by apical membrane vesicles of rat distal colon
Mascolo N, Rajendran V, Binder H. Mechanism of short-chain fatty acid uptake by apical membrane vesicles of rat distal colon. Gastroenterology 1991, 101: 331-338. PMID: 2065907, DOI: 10.1016/0016-5085(91)90008-9.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsAnionsBicarbonatesBiological Transport, ActiveButyratesButyric AcidCell MembraneColonFatty Acids, VolatileHydrogen-Ion ConcentrationIn Vitro TechniquesIntestinal AbsorptionRatsRats, Inbred Strains
1990
Active potassium absorption in rat distal colon.
Sweiry J, Binder H. Active potassium absorption in rat distal colon. The Journal Of Physiology 1990, 423: 155-170. PMID: 2143781, PMCID: PMC1189751, DOI: 10.1113/jphysiol.1990.sp018016.Peer-Reviewed Original ResearchConceptsNa-depleted animalsRat distal colonActive potassium absorptionDistal colonNormal colonFree Ringer solutionGroups of animalsResult of inhibitionColonMucosal ouabainPotassium absorptionRinger's solutionSerosal solutionSerosalAnimalsApical membraneSaturable fluxMucosaAffinity constantsOmeprazoleATPaseSecretion
1989
Regulation of active sodium and potassium transport in the distal colon of the rat. Role of the aldosterone and glucocorticoid receptors.
Turnamian S, Binder H. Regulation of active sodium and potassium transport in the distal colon of the rat. Role of the aldosterone and glucocorticoid receptors. Journal Of Clinical Investigation 1989, 84: 1924-1929. PMID: 2592566, PMCID: PMC304073, DOI: 10.1172/jci114380.Peer-Reviewed Original ResearchConceptsElectrogenic sodium absorptionReceptor-specific agonistsSodium absorptionAldosterone receptorsRU 28362Continuous infusionDistal colonGlucocorticoid receptorAmiloride-sensitive sodium absorptionColonic electrolyte transportEffects of aldosteroneRat distal colonPotassium transportActive sodiumPotassium secretionAldosteroneSustained increasePotassium absorptionAgonistsReceptorsElectrolyte transportGlucocorticoidsUnidirectional NaInfusionColonEffects of corticosteroid hormones on the electrophysiology of rat distal colon: implications for Na+ and K+ transport.
Binder H, McGlone F, Sandle G. Effects of corticosteroid hormones on the electrophysiology of rat distal colon: implications for Na+ and K+ transport. The Journal Of Physiology 1989, 410: 425-441. PMID: 2795485, PMCID: PMC1190488, DOI: 10.1113/jphysiol.1989.sp017542.Peer-Reviewed Original ResearchConceptsRU 28362Rat distal colonDistal colonCorticosteroid hormonesChannel blocker tetraethylammonium chlorideEffects of aldosteroneCase of aldosteroneTypes of receptorsChannel blocker amilorideMineralocorticoid receptorEpithelial responseAldosteroneControl animalsGlucocorticoid receptorPattern of responseConventional microelectrodesCell membrane changesTetraethylammonium chlorideCorticosteroidsReceptorsSpironolactoneColonDexamethasoneHormonePotencyDifferential effects of corticosteroids on active electrolyte transport in the mammalian distal colon.
Binder H, Turnamian S. Differential effects of corticosteroids on active electrolyte transport in the mammalian distal colon. Supplementum, Acta Veterinaria Scandinavica 1989, 86: 174-80. PMID: 2635815.Peer-Reviewed Original Research
1987
Mechanism of electroneutral sodium chloride absorption in distal colon of the rat
Binder H, Foster E, Budinger M, Hayslett J. Mechanism of electroneutral sodium chloride absorption in distal colon of the rat. Gastroenterology 1987, 93: 449-455. PMID: 3609655, DOI: 10.1016/0016-5085(87)90905-x.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAmilorideAnimalsBicarbonatesBiological Transport, ActiveColonElectric ConductivityFurosemideIntestinal AbsorptionIon ExchangeRatsRats, Inbred StrainsSodium ChlorideTheophyllineConceptsSodium chloride absorptionElectroneutral sodium chloride absorptionNet sodium absorptionNet chloride absorptionDistal colonChloride absorptionSodium absorptionRat distal colonSodium chloride cotransportVoltage-clamp conditionsMM furosemideMM amilorideMucosal bathing solutionChloride transportClamp conditionsColonBathing solutionRatsElectrogenic sodiumMechanism of sodiumAmilorideSodiumAbsence of potassiumCotransportMucosa
1986
Dietary potassium modulates active potassium absorption and secretion in rat distal colon
Foster E, Sandle G, Hayslett J, Binder H. Dietary potassium modulates active potassium absorption and secretion in rat distal colon. American Journal Of Physiology 1986, 251: g619-g626. PMID: 3022598, DOI: 10.1152/ajpgi.1986.251.5.g619.Peer-Reviewed Original ResearchConceptsNet potassium absorptionNet potassium secretionPotassium secretionDistal colonic mucosaPotassium-loaded ratsRat distal colonPotassium transportActive potassium absorptionDietary potassiumPotassium absorptionColonic mucosaDistal colonMucosal amilorideLarge intestinePotassium depletionBody storesActive potassium transportSecretionBathing solutionPotassium loadingGroupK fluxesMucosaColonControlSodium and chloride transport in the large intestine of potassium-loaded rats
Budinger M, Foster E, Hayslett J, Binder H. Sodium and chloride transport in the large intestine of potassium-loaded rats. American Journal Of Physiology 1986, 251: g249-g252. PMID: 2426972, DOI: 10.1152/ajpgi.1986.251.2.g249.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAldosteroneAmilorideAnimalsBiological Transport, ActiveChloridesColonIon ChannelsMalePotassiumRatsRats, Inbred StrainsSodiumSodium-Potassium-Exchanging ATPaseConceptsPotassium secretionSodium absorptionRat distal colonic mucosaElectroneutral sodium chloride absorptionPotassium loadingNa-K-ATPase activityElectrogenic sodium absorptionDistal colonic mucosaActive potassium secretionPotassium-loaded ratsNet sodium absorptionSodium chloride absorptionActive sodium transportVoltage-clamp conditionsDietary potassiumColonic functionColonic mucosaNet chloride fluxNet sodium fluxJNanetNet sodiumLarge intestineChloride fluxSodium transportIdentical increasePotassium/proton exchange in brush-border membrane of rat ileum
Binder H, Murer H. Potassium/proton exchange in brush-border membrane of rat ileum. The Journal Of Membrane Biology 1986, 91: 77-84. PMID: 3735407, DOI: 10.1007/bf01870217.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological Transport, ActiveHydrogen-Ion ConcentrationIleumKineticsMaleMicrovilliPotassiumRatsRats, Inbred StrainsRubidiumSodiumIon transport in proximal colon of the rat. Sodium depletion stimulates neutral sodium chloride absorption.
Foster E, Budinger M, Hayslett J, Binder H. Ion transport in proximal colon of the rat. Sodium depletion stimulates neutral sodium chloride absorption. Journal Of Clinical Investigation 1986, 77: 228-235. PMID: 2418060, PMCID: PMC423331, DOI: 10.1172/jci112281.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAcetazolamideAmilorideAnimalsBiological Transport, ActiveColonHyperaldosteronismIntestinal AbsorptionIntestinal MucosaIon ChannelsMaleRatsRats, Inbred StrainsSodium ChlorideTheophyllineConceptsMu eq/hSodium-hydrogen exchangeProximal colonSodium depletionSodium absorptionDistal colonNeutral sodium chloride absorptionDistal segmentsAmiloride-sensitive sodium absorptionNet sodium absorptionSodium-depleted ratsRat distal colonSodium chloride absorptionNeutral sodium absorptionHydrogen ion secretionSecondary hyperaldosteronismParallel fallRat colonControl groupMM amilorideMucosal amilorideJNanetColonIon secretionChloride absorption
1983
Cyclic Adenosine Monophosphate Stimulates Active Potassium Secretion in the Rat Colon
Foster E, Sandle G, Hayslett J, Binder H. Cyclic Adenosine Monophosphate Stimulates Active Potassium Secretion in the Rat Colon. Gastroenterology 1983, 84: 324-330. PMID: 6293907, DOI: 10.1016/s0016-5085(83)80130-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBethanechol CompoundsBiological Transport, ActiveBucladesineColonDietIntestinal MucosaIon ChannelsMalePotassiumRatsRats, Inbred StrainsStimulation, ChemicalTheophyllineConceptsActive potassium secretionNormal potassium dietPotassium secretionNet potassium secretionPotassium dietCyclic adenosine monophosphateDibutyryl cyclic adenosine monophosphateRat colonAdenosine monophosphatePotassium-loaded animalsCholinergic muscarinic agonistHigh potassium dietProximal colonic mucosaCalcium-dependent processesX cm2
1982
Demonstration of net potassium absorption in mammalian colon
Hayslett J, Halevy J, Pace P, Binder H. Demonstration of net potassium absorption in mammalian colon. American Journal Of Physiology 1982, 242: g209-g214. PMID: 7065184, DOI: 10.1152/ajpgi.1982.242.3.g209.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological Transport, ActiveColonIntestinal AbsorptionMaleMembrane PotentialsPerfusionPotassiumRatsSodiumConceptsPotassium-deficient animalsNet potassium absorptionNet potassium secretionPlasma potassium levelsPotassium secretionNet potassium movementPotassium levelsPotassium-loaded animalsPotassium movementMammalian colonColon of controlLow-sodium solutionDistal colonPotassium absorptionSodium solutionControl animalsProximal segmentDistal lumensIntestinal transportNet secretionColonCarrier-mediated processSecretionAdditional studiesVivo studies