2011
Radiation decreases murine small intestinal HCO3− secretion
Zhang K, Yin L, Zhang M, Parker MD, Binder HJ, Salzman P, Zhang L, Okunieff P, Vidyasagar S. Radiation decreases murine small intestinal HCO3− secretion. International Journal Of Radiation Biology 2011, 87: 878-888. PMID: 21689053, DOI: 10.3109/09553002.2011.583314.Peer-Reviewed Original ResearchConceptsNon-irradiated miceAnion secretionBALB/c miceUpper gastrointestinal tractInhibition of basalWestern blot analysisElectrolyte imbalanceInsensitive currentsC miceJejunal tissueCyclic adenosine monophosphateCotransporter expressionMiceSecretionProtein levelsDiarrheaBlot analysisAdenosine monophosphateCesium-137 sourceBasalFree solutionInhibition
2004
Three distinct mechanisms of HCO3− secretion in rat distal colon
Vidyasagar S, Rajendran VM, Binder HJ. Three distinct mechanisms of HCO3− secretion in rat distal colon. American Journal Of Physiology - Cell Physiology 2004, 287: c612-c621. PMID: 15308466, DOI: 10.1152/ajpcell.00474.2003.Peer-Reviewed Original ResearchConceptsRat distal colonShort-chain fatty acidsColonic mucosaDistal colonRat distal colonic mucosaDistal colonic mucosaCl- channel blockerSCFA/Channel blockersSerosal layerCrypt cellsCFTR blockerMicroM DIDSApical membrane anion channelApical membraneSecretionDependent secretionColonLumen ClSecretory mechanismMammalian colonBlockersMucosaStat techniqueDIDS
2001
Na+-dependent fluid absorption in intact perfused rat colonic crypts
Geibel J, Rajendran V, Binder H. Na+-dependent fluid absorption in intact perfused rat colonic crypts. Gastroenterology 2001, 120: 144-150. PMID: 11208723, DOI: 10.1053/gast.2001.20890.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsBicarbonatesChloridesColonGanglionic StimulantsGlutamatesIn Vitro TechniquesIntestinal AbsorptionInulinIsotonic SolutionsMalePerfusionQuaternary Ammonium CompoundsRatsRats, Sprague-DawleyRinger's SolutionSodiumSodium-Hydrogen ExchangersTritiumConceptsNet fluid absorptionRat colonic cryptsCl- channel blockerFluid absorptionNeurohumoral stimulationChannel blockersColonic cryptsLumen ClAbsorptive processesInhibitor of NaCl(-) secretionAbstractTextCrypt cellsExchange inhibitorMicroperfusion techniqueFluid secretionL DIDSAmiloride analoguesMammalian colonSecretionAnion exchange inhibitorCryptsSignificant increaseAIMSSecretory process
1999
Distribution and regulation of apical Cl/anion exchanges in surface and crypt cells of rat distal colon
Rajendran V, Binder H. Distribution and regulation of apical Cl/anion exchanges in surface and crypt cells of rat distal colon. American Journal Of Physiology 1999, 276: g132-g137. PMID: 9886988, DOI: 10.1152/ajpgi.1999.276.1.g132.Peer-Reviewed Original Research
1994
Differential modulation of Na-HCO3 cotransport and Na-H exchange by pH in basolateral membrane vesicles of rat distal colon.
Rajendran V, Binder H. Differential modulation of Na-HCO3 cotransport and Na-H exchange by pH in basolateral membrane vesicles of rat distal colon. Journal Of Biological Chemistry 1994, 269: 156-160. PMID: 8276790, DOI: 10.1016/s0021-9258(17)42328-3.Peer-Reviewed Original ResearchConceptsMembrane vesiclesDifferent cellular functionsBasolateral membrane vesiclesProton concentration gradientCellular functionsIntravesicular protonsApparent KmVesiclesTransport systemNa-H exchangeCotransportDifferential modulationHigh proton concentrationProton concentrationProton stimulationNa-HCO3 cotransportConcentration gradientKmRat distal colonProteinSeparate mechanismsVmax
1993
Bicarbonate-stimulated [14C]butyrate uptake in basolateral membrane vesicles of rat distal colon
Reynolds D, Rajendran V, Binder H. Bicarbonate-stimulated [14C]butyrate uptake in basolateral membrane vesicles of rat distal colon. Gastroenterology 1993, 105: 725-732. PMID: 8359643, DOI: 10.1016/0016-5085(93)90889-k.Peer-Reviewed Original ResearchCl-HCO3 and Cl-OH exchanges mediate Cl uptake in apical membrane vesicles of rat distal colon
Rajendran V, Binder H. Cl-HCO3 and Cl-OH exchanges mediate Cl uptake in apical membrane vesicles of rat distal colon. American Journal Of Physiology 1993, 264: g874-g879. PMID: 8498514, DOI: 10.1152/ajpgi.1993.264.5.g874.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAmilorideAnimalsBicarbonatesBiological TransportBumetanideCarrier ProteinsCell MembraneChloride-Bicarbonate AntiportersChloridesColonDose-Response Relationship, DrugHydrogen-Ion ConcentrationKineticsMembrane ProteinsOxalatesRatsRats, Sprague-Dawley
1991
Sodium uptake across basolateral membrane of rat distal colon. Evidence for Na-H exchange and Na-anion cotransport.
Rajendran V, Oesterlin M, Binder H. Sodium uptake across basolateral membrane of rat distal colon. Evidence for Na-H exchange and Na-anion cotransport. Journal Of Clinical Investigation 1991, 88: 1379-1385. PMID: 1655829, PMCID: PMC295609, DOI: 10.1172/jci115444.Peer-Reviewed Original ResearchMechanism of short-chain fatty acid uptake by apical membrane vesicles of rat distal colon
Mascolo N, Rajendran V, Binder H. Mechanism of short-chain fatty acid uptake by apical membrane vesicles of rat distal colon. Gastroenterology 1991, 101: 331-338. PMID: 2065907, DOI: 10.1016/0016-5085(91)90008-9.Peer-Reviewed Original ResearchMeSH Keywords4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsAnionsBicarbonatesBiological Transport, ActiveButyratesButyric AcidCell MembraneColonFatty Acids, VolatileHydrogen-Ion ConcentrationIn Vitro TechniquesIntestinal AbsorptionRatsRats, Inbred Strains
1990
Characterization of butyrate-dependent electroneutral Na-Cl absorption in the rat distal colon
Binder H, Mehta P. Characterization of butyrate-dependent electroneutral Na-Cl absorption in the rat distal colon. Pflügers Archiv - European Journal Of Physiology 1990, 417: 365-369. PMID: 2080102, DOI: 10.1007/bf00370654.Peer-Reviewed Original ResearchConceptsCl absorptionDistal colonCyclic adenosine monophosphateMucosal cyclic adenosine monophosphateElectroneutral NaElectroneutral sodium chloride absorptionAdenosine monophosphateRat distal colonSodium chloride absorptionRinger's solutionNa-H exchangeNet Cl- absorptionCyclic AMP inhibitionNet NaColonRatsInhibitionAMP inhibitionRecent studies
1987
Mechanism of electroneutral sodium chloride absorption in distal colon of the rat
Binder H, Foster E, Budinger M, Hayslett J. Mechanism of electroneutral sodium chloride absorption in distal colon of the rat. Gastroenterology 1987, 93: 449-455. PMID: 3609655, DOI: 10.1016/0016-5085(87)90905-x.Peer-Reviewed Original ResearchConceptsSodium chloride absorptionElectroneutral sodium chloride absorptionNet sodium absorptionNet chloride absorptionDistal colonChloride absorptionSodium absorptionRat distal colonSodium chloride cotransportVoltage-clamp conditionsMM furosemideMM amilorideMucosal bathing solutionChloride transportClamp conditionsColonBathing solutionRatsElectrogenic sodiumMechanism of sodiumAmilorideSodiumAbsence of potassiumCotransportMucosa
1981
THE EFFECT OF SOMATOSTATIN AND ENKEPHALIN ON ION TRANSPORT IN THE INTESTINE*
Dobbins J, Dharmsathaphorn K, Racusen L, Binder H. THE EFFECT OF SOMATOSTATIN AND ENKEPHALIN ON ION TRANSPORT IN THE INTESTINE*. Annals Of The New York Academy Of Sciences 1981, 372: 594-612. PMID: 6122417, DOI: 10.1111/j.1749-6632.1981.tb15508.x.Peer-Reviewed Original ResearchConceptsEffect of somatostatinFinal common pathwayCa channel blockersCa-free solutionCyclic AMP levelsInflux of NaCarcinoid syndromeIntestinal motilityAntidiarrheal effectSRIF infusionSecretory diarrheaRat colonRabbit ileumAMP levelsElectrolyte absorptionStimulatory effectC1 absorptionEnkephalinDistal stepBrush border membraneCommon pathwayDiarrheaCyclic AMPNet NaSRIF