2011
Radiation decreases murine small intestinal HCO3− secretion
Zhang K, Yin L, Zhang M, Parker MD, Binder HJ, Salzman P, Zhang L, Okunieff P, Vidyasagar S. Radiation decreases murine small intestinal HCO3− secretion. International Journal Of Radiation Biology 2011, 87: 878-888. PMID: 21689053, DOI: 10.3109/09553002.2011.583314.Peer-Reviewed Original ResearchConceptsNon-irradiated miceAnion secretionBALB/c miceUpper gastrointestinal tractInhibition of basalWestern blot analysisElectrolyte imbalanceInsensitive currentsC miceJejunal tissueCyclic adenosine monophosphateCotransporter expressionMiceSecretionProtein levelsDiarrheaBlot analysisAdenosine monophosphateCesium-137 sourceBasalFree solutionInhibition
2004
Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum
Hoque KM, Rajendran VM, Binder HJ. Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum. AJP Gastrointestinal And Liver Physiology 2004, 288: g956-g963. PMID: 15618279, DOI: 10.1152/ajpgi.00441.2004.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAnimalsBariumCarbacholChloridesColforsinCyclic AMPDiarrheaEnterocytesIleumMaleMembrane GlycoproteinsMonosaccharide Transport ProteinsPotassium ChannelsRatsRats, Sprague-DawleySodiumSodium-Glucose Transporter 1Sodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2Time FactorsZincConceptsCl(-) secretionRat ileumNa absorptionK channel blockadeBumetanide-sensitive 86Rb uptakeK channelsPresence of ouabainHalf maximal inhibitory concentrationNa-K-ATPaseAcute diarrheaStool outputCAMP-induced Cl- secretionMucosal additionMuscle layerAnion secretionLucite chamberCotransport activitySecretionClamp methodInhibitory concentrationDiarrheaCyclic monophosphateIleumEfflux experimentsSerosalThree distinct mechanisms of HCO3− secretion in rat distal colon
Vidyasagar S, Rajendran VM, Binder HJ. Three distinct mechanisms of HCO3− secretion in rat distal colon. American Journal Of Physiology - Cell Physiology 2004, 287: c612-c621. PMID: 15308466, DOI: 10.1152/ajpcell.00474.2003.Peer-Reviewed Original ResearchConceptsRat distal colonShort-chain fatty acidsColonic mucosaDistal colonRat distal colonic mucosaDistal colonic mucosaCl- channel blockerSCFA/Channel blockersSerosal layerCrypt cellsCFTR blockerMicroM DIDSApical membrane anion channelApical membraneSecretionDependent secretionColonLumen ClSecretory mechanismMammalian colonBlockersMucosaStat techniqueDIDS
2003
Na-H Exchange Function in Colonic Epithelial Cells
Binder H, Rajendran V, Geibel J. Na-H Exchange Function in Colonic Epithelial Cells. 2003, 71-90. DOI: 10.1007/978-1-4615-0427-6_5.Peer-Reviewed Original ResearchColonic epithelial cellsShort-chain fatty acidsEpithelial cellsSmall intestinal epithelial cellsAbsorption of carbohydratesIntestinal epithelial cellsSecretion of fluidEpithelial cell functionNeonatal periodCrypt cellsDistal segmentsCell functionSignificant heterogeneityMammalian colonSecretory processColonFatty acidsCl transportMultiple factorsCellsNutrient absorptionExchange functionHormoneSecretion
2002
HKcαEncodes Ouabain-insensitive H,K-ATPase in Surface Cells of Rat Distal Colon
Binder H. HKcαEncodes Ouabain-insensitive H,K-ATPase in Surface Cells of Rat Distal Colon. 2002, 43-52. DOI: 10.1007/978-1-4615-0971-4_4.Peer-Reviewed Original ResearchRenal functionK secretionActive K secretionNormal renal functionReduced renal functionActive K absorptionDietary K intakeNormal dietary intakeRat distal colonNet K secretionMammalian colonK-ATPaseK homeostasisActive transport mechanismK intakeDistal colonDietary intakeExperimental animalsLarge intestineK absorptionTransport mechanismColonSecretionImportant siteNormal conditions
2001
Na+-dependent fluid absorption in intact perfused rat colonic crypts
Geibel J, Rajendran V, Binder H. Na+-dependent fluid absorption in intact perfused rat colonic crypts. Gastroenterology 2001, 120: 144-150. PMID: 11208723, DOI: 10.1053/gast.2001.20890.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic AcidAnimalsBicarbonatesChloridesColonGanglionic StimulantsGlutamatesIn Vitro TechniquesIntestinal AbsorptionInulinIsotonic SolutionsMalePerfusionQuaternary Ammonium CompoundsRatsRats, Sprague-DawleyRinger's SolutionSodiumSodium-Hydrogen ExchangersTritiumConceptsNet fluid absorptionRat colonic cryptsCl- channel blockerFluid absorptionNeurohumoral stimulationChannel blockersColonic cryptsLumen ClAbsorptive processesInhibitor of NaCl(-) secretionAbstractTextCrypt cellsExchange inhibitorMicroperfusion techniqueFluid secretionL DIDSAmiloride analoguesMammalian colonSecretionAnion exchange inhibitorCryptsSignificant increaseAIMSSecretory process
2000
Cl‐Dependent Na‐H Exchange: A Novel Colonic Crypt Transport Mechanism
BINDER H, RAJENDRAN V, GEIBEL J. Cl‐Dependent Na‐H Exchange: A Novel Colonic Crypt Transport Mechanism. Annals Of The New York Academy Of Sciences 2000, 915: 43-53. PMID: 11193600, DOI: 10.1111/j.1749-6632.2000.tb05222.x.Peer-Reviewed Original Research
1999
Stimulation of Sodium Chloride Absorption from Secreting Rat Colon by Short-Chain Fatty Acids
Krishnan S, Ramakrishna BS, Binder H. Stimulation of Sodium Chloride Absorption from Secreting Rat Colon by Short-Chain Fatty Acids. Digestive Diseases And Sciences 1999, 44: 1924-1930. PMID: 10505736, DOI: 10.1023/a:1018871412748.Peer-Reviewed Original ResearchConceptsShort-chain fatty acidsNa absorptionNaCl absorptionControl normal mucosaNet Cl secretionRat distal colonSodium chloride absorptionPresence of SCFAEffect of butyrateElectroneutral NaCl absorptionVoltage-clamp conditionsFatty acidsDistal colonNormal mucosaRat colonAbsorptive pathwaysCl(-) secretionChloride absorptionColonCAMP elevationSCFAMucosaSecretagoguesAdenosine monophosphateSecretion
1990
Active potassium absorption in rat distal colon.
Sweiry J, Binder H. Active potassium absorption in rat distal colon. The Journal Of Physiology 1990, 423: 155-170. PMID: 2143781, PMCID: PMC1189751, DOI: 10.1113/jphysiol.1990.sp018016.Peer-Reviewed Original ResearchConceptsNa-depleted animalsRat distal colonActive potassium absorptionDistal colonNormal colonFree Ringer solutionGroups of animalsResult of inhibitionColonMucosal ouabainPotassium absorptionRinger's solutionSerosal solutionSerosalAnimalsApical membraneSaturable fluxMucosaAffinity constantsOmeprazoleATPaseSecretionAldosterone and glucocorticoid receptor-specific agonists regulate ion transport in rat proximal colon
Turnamian S, Binder H. Aldosterone and glucocorticoid receptor-specific agonists regulate ion transport in rat proximal colon. American Journal Of Physiology 1990, 258: g492-g498. PMID: 2138421, DOI: 10.1152/ajpgi.1990.258.3.g492.Peer-Reviewed Original ResearchConceptsDietary sodium depletionBody wt-1RU 28362Receptor-specific agonistsSodium depletionPotassium secretionProximal colonDay 1Glucocorticoid receptorWT-1Cl absorptionAdministration of spironolactoneActive potassium secretionRat proximal colonSecondary hyperaldosteronismContinuous infusionAldosteroneGlucocorticoid agonistAgonistsElectrolyte transportSecretionStimulationSignificant increaseInfusionColon
1989
Characterization of aldosterone-induced potassium secretion in rat distal colon.
Sweiry J, Binder H. Characterization of aldosterone-induced potassium secretion in rat distal colon. Journal Of Clinical Investigation 1989, 83: 844-851. PMID: 2921323, PMCID: PMC303757, DOI: 10.1172/jci113967.Peer-Reviewed Original Research
1988
Electrolyte transport in distal colon of sodium-depleted rats: effect of sodium repletion
Turnamian S, Binder H. Electrolyte transport in distal colon of sodium-depleted rats: effect of sodium repletion. American Journal Of Physiology 1988, 255: g329-g338. PMID: 2844099, DOI: 10.1152/ajpgi.1988.255.3.g329.Peer-Reviewed Original ResearchConceptsElectrogenic sodium absorptionElectroneutral sodium chloride absorptionPlasma aldosterone levelsAldosterone levelsSodium chloride absorptionPotassium secretionSodium absorptionSodium repletionDistal colonChloride absorptionElevated plasma aldosterone levelsSodium depletion increasesDistal colonic mucosaSodium-depleted ratsElectroneutral sodium absorptionRat distal colonExcess aldosteroneVoltage-clamp conditionsDietary sodiumColonic mucosaNormal animalsUnidirectional 22NaATPase activityElectrolyte transportSecretion
1987
Chapter 21 Potassium Adataptation in Mammalian Colon
Hayslett J, Binder H, Kashgarian M. Chapter 21 Potassium Adataptation in Mammalian Colon. Current Topics In Membranes 1987, 28: 457-468. DOI: 10.1016/s0070-2161(08)60425-6.Peer-Reviewed Original ResearchMammalian colonBasolateral cell membraneCell surfaceCell membraneElectrical gradientActive K secretionElectrochemical gradientK transportPotential-independent mechanismsIndependent mechanismsPotential-dependent mechanismK adaptationIntracellular KDependent mechanismK secretionShunt pathwayCarrier-mediated processCellsK leakPotassium adaptationPassive diffusionMembraneActive K transportAdaptationSecretion
1986
Dietary potassium modulates active potassium absorption and secretion in rat distal colon
Foster E, Sandle G, Hayslett J, Binder H. Dietary potassium modulates active potassium absorption and secretion in rat distal colon. American Journal Of Physiology 1986, 251: g619-g626. PMID: 3022598, DOI: 10.1152/ajpgi.1986.251.5.g619.Peer-Reviewed Original ResearchConceptsNet potassium absorptionNet potassium secretionPotassium secretionDistal colonic mucosaPotassium-loaded ratsRat distal colonPotassium transportActive potassium absorptionDietary potassiumPotassium absorptionColonic mucosaDistal colonMucosal amilorideLarge intestinePotassium depletionBody storesActive potassium transportSecretionBathing solutionPotassium loadingGroupK fluxesMucosaColonControl
1985
The electrical basis for enhanced potassium secretion in rat distal colon during dietary potassium loading
Sandle G, Foster E, Lewis S, Binder H, Hayslett J. The electrical basis for enhanced potassium secretion in rat distal colon during dietary potassium loading. Pflügers Archiv - European Journal Of Physiology 1985, 403: 433-439. PMID: 2409517, DOI: 10.1007/bf00589258.Peer-Reviewed Original ResearchConceptsRat distal colonDistal colonPotassium secretionDietary potassium loadingPotassium channel blocker tetraethylammonium chlorideBasolateral membrane voltageChannel blocker tetraethylammonium chloridePotassium loadingSodium channel blocker amilorideActive potassium secretionElectrical basisEnhanced potassium secretionChannel blocker amilorideMembrane conductanceIntracellular potassium activityApical membrane resistanceMucosal additionPotassium-selective microelectrodesBasal conditionsControl tissuesTransepithelial voltageColonMembrane voltageSecretionTetraethylammonium chloride
1984
The Pathophysiology of Diarrhea
Binder H. The Pathophysiology of Diarrhea. Hospital Practice 1984, 19: 107-118. PMID: 6148347, DOI: 10.1080/21548331.1984.11702924.Peer-Reviewed Original Research
1982
Mechanism of potassium adaptation
Hayslett J, Binder H. Mechanism of potassium adaptation. American Journal Of Physiology 1982, 243: f103-f112. PMID: 7051849, DOI: 10.1152/ajprenal.1982.243.2.f103.Peer-Reviewed Original ResearchConceptsPotassium secretionPotassium adaptationChronic renal insufficiencyNa-K-ATPase activityAdministration of glucocorticoidsPotassium loadingNa-K-ATPaseTransepithelial potential differenceRenal insufficiencyPotassium excretionColonic mucosaExcretory loadDietary potassium loadingDistal nephronLarge intestinePotassium homeostasisDietary loadingElevated levelsPotassium pumpBasolateral portionEpitheliumCellular changesDistal portionSecretionBasolateral cell membraneDemonstration of net potassium absorption in mammalian colon
Hayslett J, Halevy J, Pace P, Binder H. Demonstration of net potassium absorption in mammalian colon. American Journal Of Physiology 1982, 242: g209-g214. PMID: 7065184, DOI: 10.1152/ajpgi.1982.242.3.g209.Peer-Reviewed Original ResearchConceptsPotassium-deficient animalsNet potassium absorptionNet potassium secretionPlasma potassium levelsPotassium secretionNet potassium movementPotassium levelsPotassium-loaded animalsPotassium movementMammalian colonColon of controlLow-sodium solutionDistal colonPotassium absorptionSodium solutionControl animalsProximal segmentDistal lumensIntestinal transportNet secretionColonCarrier-mediated processSecretionAdditional studiesVivo studies
1976
Absorptive and Secretory Processes in Intestine
Binder H. Absorptive and Secretory Processes in Intestine. 1976, 45-49. DOI: 10.1007/978-94-011-6156-5_3.Peer-Reviewed Original Research