2010
Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea
Binder HJ. Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea. Annual Review Of Physiology 2010, 72: 297-313. PMID: 20148677, DOI: 10.1146/annurev-physiol-021909-135817.Peer-Reviewed Original ResearchConceptsShort-chain fatty acidsColonic microbiotaProduction of SCFAsOral rehydration solutionYears of ageShort-chain fatty acid transportAdministration of PEGColonic epithelial cellsAcute diarrheaRehydration solutionSCFA synthesisCyclic AMP-independent processFatty acid transportDiarrheaApical membrane NaFluid absorptionEpithelial cellsSCFA productionAcid transportORSFatty acidsMicrobiotaMembrane NaStoolColon
2003
Na-H Exchange Function in Colonic Epithelial Cells
Binder H, Rajendran V, Geibel J. Na-H Exchange Function in Colonic Epithelial Cells. 2003, 71-90. DOI: 10.1007/978-1-4615-0427-6_5.Peer-Reviewed Original ResearchColonic epithelial cellsShort-chain fatty acidsEpithelial cellsSmall intestinal epithelial cellsAbsorption of carbohydratesIntestinal epithelial cellsSecretion of fluidEpithelial cell functionNeonatal periodCrypt cellsDistal segmentsCell functionSignificant heterogeneityMammalian colonSecretory processColonFatty acidsCl transportMultiple factorsCellsNutrient absorptionExchange functionHormoneSecretion
2000
Amylase-Resistant Starch plus Oral Rehydration Solution for Cholera
Ramakrishna BS, Venkataraman S, Srinivasan P, Dash P, Young G, Binder H. Amylase-Resistant Starch plus Oral Rehydration Solution for Cholera. New England Journal Of Medicine 2000, 342: 308-313. PMID: 10655529, DOI: 10.1056/nejm200002033420502.Peer-Reviewed Original ResearchConceptsOral rehydration solutionDuration of diarrheaOral rehydration therapyStandard therapyAmylase-resistant starchRehydration solutionFecal weightRehydration therapyStandard oral rehydration therapyMean fecal weightResistant starch groupStandard therapy groupPrimary end pointShort-chain fatty acidsMean durationFecal excretionDiarrheaTherapySodium absorptionEnd pointFluid lossLength of timeCholeraFatty acidsDuration
1999
Stimulation of Sodium Chloride Absorption from Secreting Rat Colon by Short-Chain Fatty Acids
Krishnan S, Ramakrishna BS, Binder H. Stimulation of Sodium Chloride Absorption from Secreting Rat Colon by Short-Chain Fatty Acids. Digestive Diseases And Sciences 1999, 44: 1924-1930. PMID: 10505736, DOI: 10.1023/a:1018871412748.Peer-Reviewed Original ResearchConceptsShort-chain fatty acidsNa absorptionNaCl absorptionControl normal mucosaNet Cl secretionRat distal colonSodium chloride absorptionPresence of SCFAEffect of butyrateElectroneutral NaCl absorptionVoltage-clamp conditionsFatty acidsDistal colonNormal mucosaRat colonAbsorptive pathwaysCl(-) secretionChloride absorptionColonCAMP elevationSCFAMucosaSecretagoguesAdenosine monophosphateSecretion
1994
Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon
Rajendran V, Binder H. Apical membrane Cl-butyrate exchange: Mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon. The Journal Of Membrane Biology 1994, 141: 51-58. PMID: 7966245, DOI: 10.1007/bf00232873.Peer-Reviewed Original ResearchConceptsRat distal colonFatty acid stimulationDistal colonShort-chain fatty acidsNa-H exchangeActive chloride absorptionHalf maximal inhibitory concentrationAcid stimulationApical membrane vesiclesChain fatty acidsChloride absorptionFatty acid exchangeCl- gradientInhibitory concentrationOutward Cl gradientButyrate concentrationExtravesicular ClColonCellular modelMembrane vesiclesFatty acidsStimulationFunctional NaDisulfonic acidCompelling evidence
1989
Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon
Binder H, Mehta P. Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology 1989, 96: 989-996. PMID: 2925072, DOI: 10.1016/0016-5085(89)91614-4.Peer-Reviewed Original ResearchConceptsRat distal colonShort-chain fatty acidsCl absorptionDistal colonNa absorptionNet NaFatty acid stimulationNa-H exchangeHCO3- Ringer's solutionStimulation of NaColonic NaNet Cl- absorptionVoltage-clamp conditionsCarbonic anhydrase inhibitorsFatty acidsCoupling of NaMucosal amilorideChloride absorptionUnidirectional 22NaClamp conditionsButyrate stimulationStimulationColonActive sodiumAcid stimulation
1981
Prevalence of Nephrolithiasis in Malabsorptive Syndromes
Dharmsathaphorn K, Freeman D, Binder H, Dobbins J. Prevalence of Nephrolithiasis in Malabsorptive Syndromes. 1981, 169-172. DOI: 10.1007/978-1-4684-8977-4_28.Peer-Reviewed Original ResearchInflammatory bowel diseaseIncidence of nephrolithiasisPrevalence of nephrolithiasisUric acid stonesMalabsorptive syndromeIleal diseaseBowel diseaseCalcium oxalateDietary oxalateInsoluble calcium oxalateAcid stonesPatientsNephrolithiasisFatty acids bindColonDiseaseFatty acidsIleostomySteatorrheaResectionHyperoxaluriaSyndromeBypassPrevalenceIncidence