2011
Radiation decreases murine small intestinal HCO3− secretion
Zhang K, Yin L, Zhang M, Parker MD, Binder HJ, Salzman P, Zhang L, Okunieff P, Vidyasagar S. Radiation decreases murine small intestinal HCO3− secretion. International Journal Of Radiation Biology 2011, 87: 878-888. PMID: 21689053, DOI: 10.3109/09553002.2011.583314.Peer-Reviewed Original ResearchConceptsNon-irradiated miceAnion secretionBALB/c miceUpper gastrointestinal tractInhibition of basalWestern blot analysisElectrolyte imbalanceInsensitive currentsC miceJejunal tissueCyclic adenosine monophosphateCotransporter expressionMiceSecretionProtein levelsDiarrheaBlot analysisAdenosine monophosphateCesium-137 sourceBasalFree solutionInhibition
2010
Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea
Binder HJ. Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea. Annual Review Of Physiology 2010, 72: 297-313. PMID: 20148677, DOI: 10.1146/annurev-physiol-021909-135817.Peer-Reviewed Original ResearchConceptsShort-chain fatty acidsColonic microbiotaProduction of SCFAsOral rehydration solutionYears of ageShort-chain fatty acid transportAdministration of PEGColonic epithelial cellsAcute diarrheaRehydration solutionSCFA synthesisCyclic AMP-independent processFatty acid transportDiarrheaApical membrane NaFluid absorptionEpithelial cellsSCFA productionAcid transportORSFatty acidsMicrobiotaMembrane NaStoolColon
2006
Amylase‐Resistant Starch as Adjunct to Oral Rehydration Therapy in Children with Diarrhea
Raghupathy P, Ramakrishna BS, Oommen SP, Ahmed MS, Priyaa G, Dziura J, Young GP, Binder HJ. Amylase‐Resistant Starch as Adjunct to Oral Rehydration Therapy in Children with Diarrhea. Journal Of Pediatric Gastroenterology And Nutrition 2006, 42: 362-368. PMID: 16641573, DOI: 10.1097/01.mpg.0000214163.83316.41.Peer-Reviewed Original ResearchConceptsOral rehydration solutionAmylase-resistant starchGlucose-ORSDuration of diarrheaStool weightAcute diarrheaStandard treatmentFluid absorptionG-ORS groupMean stool weightIntravenous fluid therapyAcute watery diarrheaOral rehydration therapySeverity of diarrheaTreatment of diarrheaShort-chain fatty acidsColonic sodiumEvaluable dataRehydration therapyTreatment failureFluid therapyWatery diarrheaRehydration solutionIntestinal sodiumDiarrhea
2004
Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum
Hoque KM, Rajendran VM, Binder HJ. Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum. AJP Gastrointestinal And Liver Physiology 2004, 288: g956-g963. PMID: 15618279, DOI: 10.1152/ajpgi.00441.2004.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAnimalsBariumCarbacholChloridesColforsinCyclic AMPDiarrheaEnterocytesIleumMaleMembrane GlycoproteinsMonosaccharide Transport ProteinsPotassium ChannelsRatsRats, Sprague-DawleySodiumSodium-Glucose Transporter 1Sodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2Time FactorsZincConceptsCl(-) secretionRat ileumNa absorptionK channel blockadeBumetanide-sensitive 86Rb uptakeK channelsPresence of ouabainHalf maximal inhibitory concentrationNa-K-ATPaseAcute diarrheaStool outputCAMP-induced Cl- secretionMucosal additionMuscle layerAnion secretionLucite chamberCotransport activitySecretionClamp methodInhibitory concentrationDiarrheaCyclic monophosphateIleumEfflux experimentsSerosal
2000
Amylase-Resistant Starch plus Oral Rehydration Solution for Cholera
Ramakrishna BS, Venkataraman S, Srinivasan P, Dash P, Young G, Binder H. Amylase-Resistant Starch plus Oral Rehydration Solution for Cholera. New England Journal Of Medicine 2000, 342: 308-313. PMID: 10655529, DOI: 10.1056/nejm200002033420502.Peer-Reviewed Original ResearchConceptsOral rehydration solutionDuration of diarrheaOral rehydration therapyStandard therapyAmylase-resistant starchRehydration solutionFecal weightRehydration therapyStandard oral rehydration therapyMean fecal weightResistant starch groupStandard therapy groupPrimary end pointShort-chain fatty acidsMean durationFecal excretionDiarrheaTherapySodium absorptionEnd pointFluid lossLength of timeCholeraFatty acidsDuration
1990
Pathophysiology of acute diarrhea
Binder H. Pathophysiology of acute diarrhea. The American Journal Of Medicine 1990, 88: s2-s4. PMID: 2356845, DOI: 10.1016/0002-9343(90)90267-h.Peer-Reviewed Original ResearchConceptsFluid absorptionAcute infectious diarrheaMajor health problemSpecific pathogenic mechanismsElectrolyte movementStool consistencyStool frequencyIntestinal motilityStool volumeAcute diarrheaIntestinal secretionInfectious diarrheaAntidiarrheal agentsWater excretionDiarrheaPathogenic mechanismsInfectious agentsHealth problemsIntestinal tractEpithelial cellsTissue invasionLuminal osmolalitySymptomsEnterotoxin productionSigns
1984
The Pathophysiology of Diarrhea
Binder H. The Pathophysiology of Diarrhea. Hospital Practice 1984, 19: 107-118. PMID: 6148347, DOI: 10.1080/21548331.1984.11702924.Peer-Reviewed Original Research
1982
Increased risk of nephrolithiasis in patients with steatorrhea
Dharmsathaphorn K, Freeman D, Binder H, Dobbins J. Increased risk of nephrolithiasis in patients with steatorrhea. Digestive Diseases And Sciences 1982, 27: 401-405. PMID: 7075427, DOI: 10.1007/bf01295647.Peer-Reviewed Original ResearchConceptsIleal diseaseRisk of nephrolithiasisIncidence of nephrolithiasisRisk factorsRelative riskLonger risk factorsSerum uric acidFecal fat analysisUrine specific gravityControl patientsAdult patientsMale patientsSerum calciumMale sexDietary oxalateSteatorrheaFecal fatPatientsNephrolithiasisDiseaseUric acidDiarrheaHyperoxaluriaRiskSex
1981
THE EFFECT OF SOMATOSTATIN AND ENKEPHALIN ON ION TRANSPORT IN THE INTESTINE*
Dobbins J, Dharmsathaphorn K, Racusen L, Binder H. THE EFFECT OF SOMATOSTATIN AND ENKEPHALIN ON ION TRANSPORT IN THE INTESTINE*. Annals Of The New York Academy Of Sciences 1981, 372: 594-612. PMID: 6122417, DOI: 10.1111/j.1749-6632.1981.tb15508.x.Peer-Reviewed Original ResearchConceptsEffect of somatostatinFinal common pathwayCa channel blockersCa-free solutionCyclic AMP levelsInflux of NaCarcinoid syndromeIntestinal motilityAntidiarrheal effectSRIF infusionSecretory diarrheaRat colonRabbit ileumAMP levelsElectrolyte absorptionStimulatory effectC1 absorptionEnkephalinDistal stepBrush border membraneCommon pathwayDiarrheaCyclic AMPNet NaSRIF