2010
Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea
Binder HJ. Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea. Annual Review Of Physiology 2010, 72: 297-313. PMID: 20148677, DOI: 10.1146/annurev-physiol-021909-135817.Peer-Reviewed Original ResearchConceptsShort-chain fatty acidsColonic microbiotaProduction of SCFAsOral rehydration solutionYears of ageShort-chain fatty acid transportAdministration of PEGColonic epithelial cellsAcute diarrheaRehydration solutionSCFA synthesisCyclic AMP-independent processFatty acid transportDiarrheaApical membrane NaFluid absorptionEpithelial cellsSCFA productionAcid transportORSFatty acidsMicrobiotaMembrane NaStoolColon
2006
Amylase‐Resistant Starch as Adjunct to Oral Rehydration Therapy in Children with Diarrhea
Raghupathy P, Ramakrishna BS, Oommen SP, Ahmed MS, Priyaa G, Dziura J, Young GP, Binder HJ. Amylase‐Resistant Starch as Adjunct to Oral Rehydration Therapy in Children with Diarrhea. Journal Of Pediatric Gastroenterology And Nutrition 2006, 42: 362-368. PMID: 16641573, DOI: 10.1097/01.mpg.0000214163.83316.41.Peer-Reviewed Original ResearchConceptsOral rehydration solutionAmylase-resistant starchGlucose-ORSDuration of diarrheaStool weightAcute diarrheaStandard treatmentFluid absorptionG-ORS groupMean stool weightIntravenous fluid therapyAcute watery diarrheaOral rehydration therapySeverity of diarrheaTreatment of diarrheaShort-chain fatty acidsColonic sodiumEvaluable dataRehydration therapyTreatment failureFluid therapyWatery diarrheaRehydration solutionIntestinal sodiumDiarrhea
2004
Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum
Hoque KM, Rajendran VM, Binder HJ. Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum. AJP Gastrointestinal And Liver Physiology 2004, 288: g956-g963. PMID: 15618279, DOI: 10.1152/ajpgi.00441.2004.Peer-Reviewed Original ResearchMeSH Keywords8-Bromo Cyclic Adenosine MonophosphateAnimalsBariumCarbacholChloridesColforsinCyclic AMPDiarrheaEnterocytesIleumMaleMembrane GlycoproteinsMonosaccharide Transport ProteinsPotassium ChannelsRatsRats, Sprague-DawleySodiumSodium-Glucose Transporter 1Sodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 2Time FactorsZincConceptsCl(-) secretionRat ileumNa absorptionK channel blockadeBumetanide-sensitive 86Rb uptakeK channelsPresence of ouabainHalf maximal inhibitory concentrationNa-K-ATPaseAcute diarrheaStool outputCAMP-induced Cl- secretionMucosal additionMuscle layerAnion secretionLucite chamberCotransport activitySecretionClamp methodInhibitory concentrationDiarrheaCyclic monophosphateIleumEfflux experimentsSerosal
1990
Pathophysiology of acute diarrhea
Binder H. Pathophysiology of acute diarrhea. The American Journal Of Medicine 1990, 88: s2-s4. PMID: 2356845, DOI: 10.1016/0002-9343(90)90267-h.Peer-Reviewed Original ResearchConceptsFluid absorptionAcute infectious diarrheaMajor health problemSpecific pathogenic mechanismsElectrolyte movementStool consistencyStool frequencyIntestinal motilityStool volumeAcute diarrheaIntestinal secretionInfectious diarrheaAntidiarrheal agentsWater excretionDiarrheaPathogenic mechanismsInfectious agentsHealth problemsIntestinal tractEpithelial cellsTissue invasionLuminal osmolalitySymptomsEnterotoxin productionSigns