The excitotoxin hypothesis in relation to cerebral ischemia.
Benveniste H. The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovascular And Brain Metabolism Reviews 1991, 3: 213-45. PMID: 1931486.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsSelective neuronal deathExcitotoxin hypothesisNeuronal deathExtracellular glutamate concentration increasesSelective vulnerable brain regionsBrain regionsN-methyl-D-aspartate receptorsGlutamate accumulationBrain cell injuryVulnerable brain regionsTransient global ischemiaHigh-performance liquid chromatographyDistinct brain regionsNeuronal injuryBrain extracellular spaceCerebral ischemiaTransient ischemiaAntagonist APVExcitatory neurotransmitterGlobal ischemiaExtracellular glutamateNMDA antagonistsCertain neuronsMicrodialysis technique