2024
Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments
Schrader J, Majchrzak M, Xu F, Lee H, Agostinucci K, Davis J, Benveniste H, Van Nostrand W. Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments. Neuroscience Insights 2024, 19: 26331055241288172. PMID: 39386146, PMCID: PMC11462563, DOI: 10.1177/26331055241288172.Peer-Reviewed Original ResearchCerebral amyloid angiopathyPathogenesis of cerebral amyloid angiopathyTGF-b1Rat modelTGF-b1 levelsType 2Few proteinsSmooth muscle cell lossTransforming growth factor beta 1Wild-type ratsProteomic changesB proteinProteomic analysisPeptidase ATransgenic rat modelPathway analysisMolecular insightsMagnetic resonance imagingCognitive impairmentAlzheimer's diseaseCell lossAmyloid depositsRatsAmyloid angiopathyCortical microhemorrhages
2021
Transgenic rat models for cerebral amyloid angiopathy type‐1 and ‐2 and related vascular cognitive impairment and dementia (VCID)
Van Nostrand W, Xu F, Lee H, Robinson J, Benveniste H. Transgenic rat models for cerebral amyloid angiopathy type‐1 and ‐2 and related vascular cognitive impairment and dementia (VCID). Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.051368.Peer-Reviewed Original ResearchCerebral amyloid angiopathyType 2 ratsWhite matter lossType 1 ratsMonths of ageCAA type 1Vascular cognitive impairmentTransgenic rat modelMagnetic resonance imagingType 1CAA pathologyCerebral microbleedsPathological featuresRat modelTypes of CAAType 2Cognitive impairmentCerebral small vessel diseaseHistological analysisNovel transgenic rat modelSmall vessel diseaseWhite matter changesReliable preclinical modelsCognitive changesParticular pathological features