Heparin inhibits induction of nitric oxide synthase by cytokines in rat brain microvascular endothelial cells
Bonmann E, Jüttler E, Krestel H, Spranger M. Heparin inhibits induction of nitric oxide synthase by cytokines in rat brain microvascular endothelial cells. Neuroscience Letters 1998, 253: 95-98. PMID: 9774158, DOI: 10.1016/s0304-3940(98)00613-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCytokinesDose-Response Relationship, DrugEndothelium, VascularEnzyme InductionHeparinInterferon-gammaInterleukin-1MicrocirculationNitric Oxide SynthaseNitric Oxide Synthase Type IIRatsRats, WistarReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsInflammatory reactionRat brain microvascular endothelial cellsInducible nitric oxide synthase (iNOS) mRNABrain microvascular endothelial cellsNitric oxide synthase mRNAMicrovascular brain endothelial cellsEndothelial cellsPossible modulatory actionIschemic brain injuryAdult rat brainBrain endothelial cellsNitric oxide synthaseReverse transcription-polymerase chain reactionNitric oxide synthesisTranscription-polymerase chain reactionMicrovascular endothelial cellsDose-dependent mannerAnticoagulatory effectCerebral ischemiaProinflammatory cytokinesINOS expressionModulatory actionPolymerase chain reactionBrain injuryOxide synthase