2023
Platelet response to influenza vaccination reflects effects of aging
Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins T, Belshe R, Chawla D, Rondina M, Gill T, Montgomery R, Allore H, Kleinstein S, Shaw A. Platelet response to influenza vaccination reflects effects of aging. Aging Cell 2023, 22: e13749. PMID: 36656789, PMCID: PMC9924941, DOI: 10.1111/acel.13749.Peer-Reviewed Original ResearchConceptsCommunity-dwelling older adultsPlatelet activationOlder adultsInfluenza vaccinationAge-associated chronic inflammationInfluence platelet functionRNA expressionPro-inflammatory diseasesAge-associated increasePlatelet activation pathwaysAge-associated differencesActivation pathwayPlatelet transcriptomeGeriatric conditionsChronic inflammationImmune responsePlatelet functionPlatelet responseSNF residentsVaccinationActivation responseYoung individualsProtein levelsAdultsYounger participants
2022
Life course traumas and cardiovascular disease—the mediating role of accelerated aging
Cao X, Zhang J, Ma C, Li X, Kuo C, Levine ME, Hu G, Allore H, Chen X, Wu X, Liu Z. Life course traumas and cardiovascular disease—the mediating role of accelerated aging. Annals Of The New York Academy Of Sciences 2022, 1515: 208-218. PMID: 35725988, PMCID: PMC10145586, DOI: 10.1111/nyas.14843.Peer-Reviewed Original ResearchDiurnal effects of polypharmacy with high drug burden index on physical activities over 23 h differ with age and sex
Tran T, Mach J, Gemikonakli G, Wu H, Allore H, Howlett SE, Little CB, Hilmer SN. Diurnal effects of polypharmacy with high drug burden index on physical activities over 23 h differ with age and sex. Scientific Reports 2022, 12: 2168. PMID: 35140291, PMCID: PMC8828819, DOI: 10.1038/s41598-022-06039-4.Peer-Reviewed Original ResearchConceptsHigher Drug Burden IndexDrug Burden IndexBurden indexYoung miceOld micePhysical activityDifferent drug regimensWeeks of treatmentDrug-induced deliriumDaily physical activityTreatment × sex interactionBehavioral changesConsideration of ageSex-specific effectsSimvastatin monotherapyDrug regimensGait speedFunctional impairmentGlobal healthcare challengePolypharmacyQuality useOlder ageBehavioral declineMiceOlder adults
2017
Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging
Hadley E, Kuchel G, Newman A, Allore H, Bartley J, Bergeman C, Blinov M, Colon-Emeric C, Dabhar F, Dugan L, Dutta C, Eldadah B, Ferrucci L, Kirkland J, Kritchevsky S, Lipsitz L, Nadkarni N, Reed M, Schmader K, Sierra F, Studenski S, Varadhan R, Walston J, Whitson H, Yung R. Report: NIA Workshop on Measures of Physiologic Resiliencies in Human Aging. The Journals Of Gerontology Series A 2017, 72: 980-990. PMID: 28475732, PMCID: PMC5861884, DOI: 10.1093/gerona/glx015.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsFocus of careAging-related factorsLaboratory animal modelsLong-term predictorsMultiple determinantsHuman agingHealthy life spanClinical dataEpidemiological studiesAnimal modelsHuman resiliencyOlder adultsHomeostatic responseAdverse effectsNational InstituteAssessing resilienceResilience outcomesPhenotype definitionResilience data
2014
Socioeconomic Stratification and Multidimensional Health Trajectories: Evidence of Convergence in Later Old Age
Xu X, Liang J, Bennett JM, Botoseneanu A, Allore HG. Socioeconomic Stratification and Multidimensional Health Trajectories: Evidence of Convergence in Later Old Age. The Journals Of Gerontology Series B 2014, 70: 661-671. PMID: 25161216, PMCID: PMC4462671, DOI: 10.1093/geronb/gbu095.Peer-Reviewed Original Research
2013
Dynamics of functional aging based on latent-class trajectories of activities of daily living
Han L, Allore H, Murphy T, Gill T, Peduzzi P, Lin H. Dynamics of functional aging based on latent-class trajectories of activities of daily living. Annals Of Epidemiology 2013, 23: 87-92. PMID: 23305692, PMCID: PMC3558979, DOI: 10.1016/j.annepidem.2012.11.010.Peer-Reviewed Original ResearchConceptsDaily livingFunctional agingCommunity-living adultsEquation Poisson modelsMost older adultsADL disabilityHigher disabilityPersistent disabilitySubstantial morbidityInstrumental ADLADL independenceDisability trajectoriesLatent class trajectoriesCumulative burdenRestricted activityLow burdenSevere disabilityMorbidityPredominant trajectoriesOlder adultsDisabilityTime trendsFunctional autonomyADLGrowth mixture models
2009
Missing Data: A Special Challenge in Aging Research
Hardy SE, Allore H, Studenski SA. Missing Data: A Special Challenge in Aging Research. Journal Of The American Geriatrics Society 2009, 57: 722-729. PMID: 19220562, PMCID: PMC2695652, DOI: 10.1111/j.1532-5415.2008.02168.x.Peer-Reviewed Original Research
2008
A Semiparametric Transition Model with Latent Traits for Longitudinal Multistate Data
Lin H, Guo Z, Peduzzi PN, Gill TM, Allore HG. A Semiparametric Transition Model with Latent Traits for Longitudinal Multistate Data. Biometrics 2008, 64: 1032-1042. PMID: 18355385, PMCID: PMC2784952, DOI: 10.1111/j.1541-0420.2008.01011.x.Peer-Reviewed Original Research