2023
Platelet response to influenza vaccination reflects effects of aging
Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins T, Belshe R, Chawla D, Rondina M, Gill T, Montgomery R, Allore H, Kleinstein S, Shaw A. Platelet response to influenza vaccination reflects effects of aging. Aging Cell 2023, 22: e13749. PMID: 36656789, PMCID: PMC9924941, DOI: 10.1111/acel.13749.Peer-Reviewed Original ResearchConceptsCommunity-dwelling older adultsPlatelet activationOlder adultsInfluenza vaccinationAge-associated chronic inflammationInfluence platelet functionRNA expressionPro-inflammatory diseasesAge-associated increasePlatelet activation pathwaysAge-associated differencesActivation pathwayPlatelet transcriptomeGeriatric conditionsChronic inflammationImmune responsePlatelet functionPlatelet responseSNF residentsVaccinationActivation responseYoung individualsProtein levelsAdultsYounger participants
2008
Review: An examination of effect estimation in factorial and standardly-tailored designs
Allore HG, Murphy TE. Review: An examination of effect estimation in factorial and standardly-tailored designs. Clinical Trials 2008, 5: 121-130. PMID: 18375650, PMCID: PMC3477845, DOI: 10.1177/1740774508089278.Peer-Reviewed Original ResearchConceptsInterventional componentsRisk factorsClinical trialsTranslational researchMulticomponent interventionIndividual component effectsRandomized clinical trialsMultiple intervention componentsInterventional trialsGeriatric conditionsIntervention armTreatment armsControl armTrial designHealth outcomesIntervention componentsTrialsMedical communityInterventionSignificant findingsArmSubjectsCurrent inabilityNet effectGeriatrics