2024
Discharge Information About Adverse Drug Reactions Indicates Lower Self-Reported Adverse Drug Reactions and Fewer Concerns in Patients After Percutaneous Coronary Intervention
Pettersen T, Schjøtt J, Allore H, Bendz B, Borregaard B, Fridlund B, Hadjistavropoulos H, Larsen A, Nordrehaug J, Rasmussen T, Rotevatn S, Valaker I, Wentzel-Larsen T, Norekvål T, Investigators C. Discharge Information About Adverse Drug Reactions Indicates Lower Self-Reported Adverse Drug Reactions and Fewer Concerns in Patients After Percutaneous Coronary Intervention. Heart Lung And Circulation 2024, 33: 350-361. PMID: 38238118, DOI: 10.1016/j.hlc.2023.12.005.Peer-Reviewed Original ResearchSelf-reported adverse drug reactionsPrescribed pharmacotherapyPotential adverse drug reactionsAdverse drug reactionsPercutaneous coronary interventionPatient-reported outcome measuresCovariate-adjusted logistic regressionConfidence intervalsNational quality registryProspective multicentre cohort studyAssociated with incidencePatients' medical recordsIntervention aimHealthcare providersQuality registryMulticentre cohort studyDischarge informationDrug reactionsInformation patientsOdds ratioOutcome measuresCohort studyHospital dischargeLogistic regressionPCI centre
2023
Sex differences in incidence of self-reported adverse drug reactions after percutaneous coronary intervention
Pettersen T, Schjott J, Allore H, Bendz B, Borregaard B, Fridlund B, Hadjistavropoulos H, Larsen A, Nordrehaug J, Rasmussen T, Rotevatn S, Valaker I, Wentzel-Larsen T, Norekval T. Sex differences in incidence of self-reported adverse drug reactions after percutaneous coronary intervention. European Heart Journal 2023, 44: ehad655.2879. DOI: 10.1093/eurheartj/ehad655.2879.Peer-Reviewed Original ResearchSelf-reported adverse drug reactionsPercutaneous coronary interventionAdverse drug reactionsPotential adverse drug reactionsPrescribed therapyCoronary interventionHospital dischargeDrug reactionsMedical recordsOdds ratioIncidence of ADRsProspective multicentre cohort studyMore adverse drug reactionsMulticentre cohort studyAcute coronary syndromeSex differencesTotal study populationConfidence intervalsPatients' medical recordsClinical drug trialsProportion of womenHeart ContinuityCoronary syndromeCohort studyPCI centerAssociations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study
Cao X, Li X, Zhang J, Sun X, Yang G, Zhao Y, Li S, Hoogendijk E, Wang X, Zhu Y, Allore H, Gill T, Liu Z. Associations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study. JMIR Public Health And Surveillance 2023, 9: e45502. PMID: 37200070, PMCID: PMC10236284, DOI: 10.2196/45502.Peer-Reviewed Original ResearchConceptsMultiple adverse outcomesChronic kidney diseaseDiabetes-related microvascular diseaseAdverse outcomesCause mortalityCardiovascular diseaseMiddle-aged adultsUK Biobank participantsHigh riskMicrovascular diseaseEye diseaseIncident type 2 diabetes mellitusType 2 diabetes mellitusProportional hazards regression modelsBiobank participantsMultivariable-adjusted modelsProspective cohort studyHazards regression modelsNormal glucose metabolismDiabetes-related burdenDiabetes-related diseasesHealth care resourcesNonfrail counterpartsFrailty assessmentCohort studyAntibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2022
Informing patients about potential adverse drug reactions after percutaneous coronary intervention reduces the occurrence of self-reported adverse drug reactions
Pettersen T, Schjott J, Allore H, Bendz B, Borregaard B, Fridlund B, Hadjistavropoulos H, Larsen A, Nordrehaug J, Rasmussen T, Rotevatn S, Valaker I, Wentzel-Larsen T, Norekval T. Informing patients about potential adverse drug reactions after percutaneous coronary intervention reduces the occurrence of self-reported adverse drug reactions. European Heart Journal 2022, 43: ehac544.2736. DOI: 10.1093/eurheartj/ehac544.2736.Peer-Reviewed Original ResearchSelf-reported adverse drug reactionsPercutaneous coronary interventionAdverse drug reactionsPotential adverse drug reactionsHospital dischargePrescribed therapyDrug reactionsCoronary interventionMedical recordsOdds ratioIncidence of ADRsProspective multicentre cohort studyStable coronary artery diseaseMulticentre cohort studyCoronary artery diseaseConfidence intervalsPatients' medical recordsHeart ContinuityInforming PatientsMore comorbiditiesIndex hospitalizationCohort studyArtery diseasePCI centerClinical variablesPerceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study
Pettersen TR, Schjøtt J, Allore HG, Bendz B, Borregaard B, Fridlund B, Larsen AI, Nordrehaug JE, Rotevatn S, Wentzel-Larsen T, Norekvål TM. Perceptions of generic medicines and medication adherence after percutaneous coronary intervention: a prospective multicentre cohort study. BMJ Open 2022, 12: e061689. PMID: 36127123, PMCID: PMC9490600, DOI: 10.1136/bmjopen-2022-061689.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionProspective multicentre cohort studyMulticentre cohort studyMedication adherenceCohort studyCoronary interventionFemale sexGeneric medicinesSelf-reported medication adherenceOlder ageSelf-reported health statusLow socioeconomic statusPoor mental healthLow education levelSecondary outcomesPCI centerBrand-name medicinesClinical variablesMean agePatients' perceptionsMAIN OUTCOMEHealth statusMental healthSocioeconomic statusTime pointsNational Cohort Study of Homebound Persons Living With Dementia: Antibiotic Prescribing Trends and Opportunities for Antibiotic Stewardship
Datta R, Fried T, O’Leary J, Zullo AR, Allore H, Han L, Juthani-Mehta M, Cohen A. National Cohort Study of Homebound Persons Living With Dementia: Antibiotic Prescribing Trends and Opportunities for Antibiotic Stewardship. Open Forum Infectious Diseases 2022, 9: ofac453. PMID: 36147594, PMCID: PMC9487603, DOI: 10.1093/ofid/ofac453.Peer-Reviewed Original ResearchHome-based primary careDays of therapyAntibiotic use ratesAntibiotic useHomebound personsOverall median lengthPhysician home visitsNational cohort studyAntibiotic prescribing trendsVeterans Health AdministrationUse ratesProvider visitsAntibiotic prescriptionsCohort studyPrescribing trendsTelephone visitsMedian agePrescription fillsMedian lengthAntibiotic stewardshipNational cohortPrimary careHome visitsHealth AdministrationPrescribed classHealth Literacy and Risk Factors for Coronary Artery Disease (From the CONCARDPCI Study)
Brørs G, Dalen H, Allore H, Deaton C, Fridlund B, Osborne RH, Palm P, Wentzel-Larsen T, Norekvål TM, investigators C. Health Literacy and Risk Factors for Coronary Artery Disease (From the CONCARDPCI Study). The American Journal Of Cardiology 2022, 179: 22-30. PMID: 35853782, DOI: 10.1016/j.amjcard.2022.06.016.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePercutaneous coronary interventionPsychologic risk factorsCAD risk factorsRisk factorsHealth literacyIndex admissionArtery diseaseLower health literacy scoresSecondary prevention careMulticenter cohort studyBehavioral risk factorsHealth Literacy QuestionnaireHealth literacy scoresLow health literacyWeekly physical activityHealth Literacy ScaleHealth literacy challengesPrevention careCohort studyCoronary interventionPoor outcomePhysical activityDepression symptomsLarger studyHealth literacy and physical and mental health status in octogenarian patients with coronary artery disease - a prospective cohort multicentre study
Instenes I, Brors G, Hjertvikrem N, Allore H, Borregaard B, Deaton C, Larsen A, Osborne R, Palm P, Thompson D, Norekval T. Health literacy and physical and mental health status in octogenarian patients with coronary artery disease - a prospective cohort multicentre study. European Journal Of Cardiovascular Nursing 2022, 21: zvac060.054. DOI: 10.1093/eurjcn/zvac060.054.Peer-Reviewed Original ResearchPercutaneous coronary interventionMental health statusGood health informationHealth Literacy QuestionnaireHealth literacyHealth statusHealth informationProspective cohort multicentre studyUnit increaseMental healthPhysical healthProspective cohort studyCoronary artery diseaseAdequate health literacyLow health literacyNumber of octogenariansSocial supportHealth-promoting behaviorsMyocardial Infarction Dimensional Assessment ScaleQuality of lifeOctogenarian patientsCohort studyCoronary interventionArtery diseasePCI centerFunctional Trajectories and Resilience Among Adults With Advanced Lung Cancer
Presley CJ, Arrato NA, Shields PG, Carbone DP, Wong ML, Benedict J, Reisinger SA, Han L, Gill TM, Allore H, Andersen BL, Janse S. Functional Trajectories and Resilience Among Adults With Advanced Lung Cancer. JTO Clinical And Research Reports 2022, 3: 100334. PMID: 35719868, PMCID: PMC9198463, DOI: 10.1016/j.jtocrr.2022.100334.Peer-Reviewed Original ResearchAdvanced NSCLCFunctional disabilityLung cancerBaseline Eastern Cooperative Oncology Group performance statusEastern Cooperative Oncology Group performance statusSevere disabilityPatient Health Questionnaire-9Adenocarcinoma histological subtypeDistinct functional trajectoriesAdvanced lung cancerProspective cohort studyRisk stratification toolFunctional trajectoriesLatent class trajectory modelingLung cancer treatmentWorse dyspneaBrain metastasesBaseline demographicsCohort studyFormer smokersPerformance statusBone metastasesEuroQol-5DStratification toolHistological subtypes
2021
Racial and Ethnic Differences in Multimorbidity Changes Over Time
Quiñones AR, Newsom JT, Elman MR, Markwardt S, Nagel CL, Dorr DA, Allore HG, Botoseneanu A. Racial and Ethnic Differences in Multimorbidity Changes Over Time. Medical Care 2021, 59: 402-409. PMID: 33821829, PMCID: PMC8024615, DOI: 10.1097/mlr.0000000000001527.Peer-Reviewed Original ResearchConceptsMinimal diseaseOlder adultsProspective cohort studyHigher depressive symptomsMultimorbidity combinationsEthnic older adultsCohort studyMultimorbidity patternsLung diseaseHeart diseaseRetirement Study respondentsDelay progressionDepressive symptomsMultimorbidityDiseaseLatent class analysisLatent classesEthnic differencesWhite AmericansStudy respondentsMultinomial logistic modelAdultsClass analysisLogistic modelParticipants
2015
Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study
Tinetti ME, McAvay G, Trentalange M, Cohen AB, Allore HG. Association between guideline recommended drugs and death in older adults with multiple chronic conditions: population based cohort study. The BMJ 2015, 351: h4984. PMID: 26432468, PMCID: PMC4591503, DOI: 10.1136/bmj.h4984.Peer-Reviewed Original ResearchConceptsSerotonin-norepinephrine reuptake inhibitorsMultiple chronic conditionsSelective serotonin reuptake inhibitorsAdjusted hazard ratioRisk of deathCalcium channel blockersChronic conditionsHazard ratioΒ-blockersCohort studyReuptake inhibitorsAtrial fibrillationOlder adultsChannel blockersCardiovascular drugsSSRIs/serotonin-norepinephrine reuptake inhibitorsRenin-angiotensin system blockersNorepinephrine reuptake inhibitorsSerotonin reuptake inhibitorsCommon combinationRAS blockersSystem blockersStudy drugHeart failureThromboembolic diseaseComparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia
Barakat LA, Juthani-Mehta M, Allore H, Trentalange M, Tate J, Rimland D, Pisani M, Akgün KM, Goetz MB, Butt AA, Rodriguez-Barradas M, Duggal M, Crothers K, Justice AC, Quagliarello VJ. Comparing clinical outcomes in HIV‐infected and uninfected older men hospitalized with community‐acquired pneumonia. HIV Medicine 2015, 16: 421-430. PMID: 25959543, PMCID: PMC5015437, DOI: 10.1111/hiv.12244.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaVeterans Aging Cohort StudyVACS IndexCAP outcomesAntiretroviral therapyOlder adultsHigher VACS indexDays of dischargeAging Cohort StudyUninfected participantsCohort studyMean LOSHIV infectionLonger LOSClinical outcomesUnadjusted analysesUninfected groupMultivariable modelEligibility criteriaHIVMale veteransMortality rateART useMortalityOutcomes
2013
Modifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study
Juthani‐Mehta M, De Rekeneire N, Allore H, Chen S, O'Leary JR, Bauer DC, Harris TB, Newman AB, Yende S, Weyant RJ, Kritchevsky S, Quagliarello V, Study F. Modifiable Risk Factors for Pneumonia Requiring Hospitalization of Community‐Dwelling Older Adults: The Health, Aging, and Body Composition Study. Journal Of The American Geriatrics Society 2013, 61: 1111-1118. PMID: 23772872, PMCID: PMC3714374, DOI: 10.1111/jgs.12325.Peer-Reviewed Original ResearchConceptsModifiable risk factorsIncident mobility limitationCommunity-dwelling older adultsBody Composition StudyRisk factorsPlaque scoresMobility limitationsOlder adultsNovel modifiable risk factorsProspective observational cohort studyObservational cohort studyNonmodifiable risk factorsCases of pneumoniaHistory of pneumoniaCommunity-dwelling adultsAverage attributable fractionMonths of baselineCohort studyExpiratory volumePneumonia preventionDental examinationPrimary outcomeOral hygieneMale sexAttributable fraction
2010
Change in Disability After Hospitalization or Restricted Activity in Older Persons
Gill TM, Allore HG, Gahbauer EA, Murphy TE. Change in Disability After Hospitalization or Restricted Activity in Older Persons. JAMA 2010, 304: 1919-1928. PMID: 21045098, PMCID: PMC3124926, DOI: 10.1001/jama.2010.1568.Peer-Reviewed Original ResearchConceptsHazard ratioPhysical frailtySevere disabilityOlder personsMild disabilityMultivariable hazard ratiosProspective cohort studyCommunity-living personsFall-related injuriesGreater New HavenState of disabilityLikelihood of recoveryCohort studyAbsolute riskFrail individualsHospitalizationDaily livingNonfrail individualsRestricted activityInjuryTelephone interviewsFrailtyIllnessMonthsDisability