2015
Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis
Schulte A, Pandeya N, Fawcett J, Fritschi L, Risch HA, Webb PM, Whiteman DC, Neale RE. Association between Helicobacter pylori and pancreatic cancer risk: a meta-analysis. Cancer Causes & Control 2015, 26: 1027-1035. PMID: 25951801, DOI: 10.1007/s10552-015-0595-3.Peer-Reviewed Original ResearchConceptsH. pylori seropositivityPancreatic cancer riskPylori seropositivityPancreatic cancerOdds ratioCancer riskAustralian population-based case-control studyConfidence intervalsH. pyloriPopulation-based case-control studyHelicobacter pyloriOverall associationStrain-specific associationsLaird random-effects modelAdjusted odds ratioCase-control studyCytotoxin-associated geneSignificant overall associationRandom-effects modelEnzyme-linked immunosorbentPancreatic cancer studiesCagA seropositivityMethodsBlood samplesEpidemiological studiesSeropositivity
2013
ABO Blood Group and Risk of Pancreatic Cancer: A Study in Shanghai and Meta-Analysis
Risch HA, Lu L, Wang J, Zhang W, Ni Q, Gao YT, Yu H. ABO Blood Group and Risk of Pancreatic Cancer: A Study in Shanghai and Meta-Analysis. American Journal Of Epidemiology 2013, 177: 1326-1337. PMID: 23652164, PMCID: PMC3732019, DOI: 10.1093/aje/kws458.Peer-Reviewed Original ResearchConceptsABO blood groupGroup BBlood groupPancreatic cancerNonendemic populationsGroup ASummary odds ratio (OR) estimatesGastric epithelial expressionPositive Helicobacter pyloriCagA-negative H. pylori strainsCytotoxin-associated genePancreatic cancer casesBlood group BOdds ratio estimatesH. pylori strainsPooled studiesCancer casesEpithelial expressionHigh riskB antigensGroup OSystematic reviewMeta-AnalysisHelicobacter pyloriPylori strains
2011
Pancreatic cancer: Helicobacter pylori colonization, N‐Nitrosamine exposures, and ABO blood group
Risch HA. Pancreatic cancer: Helicobacter pylori colonization, N‐Nitrosamine exposures, and ABO blood group. Molecular Carcinogenesis 2011, 51: 109-118. PMID: 22162235, DOI: 10.1002/mc.20826.Peer-Reviewed Original ResearchConceptsN-nitrosamine exposurePancreatic cancerPylori colonizationH. pyloriPancreatic secretory functionH. pylori colonizationHost inflammatory responseHelicobacter pylori colonizationHost-organism interactionsABO blood groupH. pylori bindsPancreatic carcinogenicityRecent genome-wide association studiesCigarette smokingGastric ulcerRisk factorsDietary intakeInflammatory responsePancreatic adenocarcinomaGastric cancerPhysiologic actionsAnimal modelsGastrointestinal epitheliumGastric colonizationHelicobacter pylori
2003
Etiology of Pancreatic Cancer, With a Hypothesis Concerning the Role of N-Nitroso Compounds and Excess Gastric Acidity
Risch HA. Etiology of Pancreatic Cancer, With a Hypothesis Concerning the Role of N-Nitroso Compounds and Excess Gastric Acidity. Journal Of The National Cancer Institute 2003, 95: 948-960. PMID: 12837831, DOI: 10.1093/jnci/95.13.948.Peer-Reviewed Original ResearchConceptsPancreatic cancerGastric acidityRisk of nonsmokersConsumption of fruitsCurrent smokersDiabetes mellitusChronic pancreatitisCigarette smokingColorectal cancerCytokine mechanismsCancer deathDietary factorsDuodenal acidityRisk factorsEpidemiologic reviewFrequent causeHigh riskLower riskN-nitroso compoundsHelicobacter pyloriCancerGermline mutationsHost genetic variationRiskAnimal foods
2001
Helicobacter pylori, gastroesophageal reflux, their interrelationships, and the risk of esophageal adenocarcinoma
Lew E, Risch H, Chow W, Gammon M, Vaughan T, Schoenberg J, Stanford J, West A, Rotterdam H, Blot W, Blaser M, Fraumeni J. Helicobacter pylori, gastroesophageal reflux, their interrelationships, and the risk of esophageal adenocarcinoma. Gastroenterology 2001, 120: a31. DOI: 10.1016/s0016-5085(08)80151-5.Peer-Reviewed Original ResearchHelicobacter pylori, gastroesophageal reflux, their interrelationships, and the risk of esophageal adenocarcinoma
LEW E, RISCH H, CHOW W, GAMMON M, VAUGHAN T, SCHOENBERG J, STANFORD J, WEST A, ROTTERDAM H, BLOT W. Helicobacter pylori, gastroesophageal reflux, their interrelationships, and the risk of esophageal adenocarcinoma. Gastroenterology 2001, 120: a31-a31. DOI: 10.1016/s0016-5085(01)80151-7.Peer-Reviewed Original Research